Headaches in Overweight Children and Adolescents Referred to a Tertiary‐care Center in Israel

Pinhas‐Hamiel, Orit; Frumin, Katia; Gabis, Lidia V.; Mazor-Aronovich, Kineret; Modan‐Moses, Dalit; Reichman, Brian; Lerner‐Geva, Liat

doi:10.1038/oby.2007.88

Cited by 64 publications

(87 citation statements)

References 24 publications

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“…Data regarding effects of obesity and headaches in children are more limited. However, an increasing number of reports suggest that obesity could also be a risk factor for migraine in the paediatric population [38][39][40]. Our study confirmed these findings.…”

Section: Discussionsupporting

confidence: 83%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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Section: Discussionsupporting

confidence: 83%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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“…Comorbidity with obesity has been reported in children and in adults with headaches (3,(23)(24)(25), but both of these conditions are widespread and conclusive results are difficult to obtain. In obese …”

Section: Discussionmentioning

confidence: 99%

“…Other associated conditions are epilepsy (10-15), asthma and allergic disorders (16), sleep disorders (17-21), celiac disease (CD) (22), and obesity (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Primary Headaches in Children: Clinical Findings and the Association with other Conditions

Pavone

Rizzo

Conti

et al. 2012

Int J Immunopathol Pharmacol

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The aim of the present study is to report on the frequency of some comorbidities in primary headaches in childhood. Two hundred and eighty children (175 males and 105 females; ratio 1.7:1), aged 4 to 14 years, affected by primary headaches were consecutively enrolled in this study. In direct interviews, parents and children gave information about the association of their headaches with different conditions including asthma and allergic disorders, convulsive episodes, sleep disorders and increased body weight, affections some time associated in the literature to headache as comorbidities . In addition, anxiety and depression, attention deficitlhyperactivity disorder, tics, learning disabilities and obsessive-compulsive disorders, using psycho-diagnostic scales were evaluated. Two hundred and eighty children matched for age, sex, race and socio-economic status; were used as controls. No significant association of primary headaches was found with asthma and allergic disorders, convulsive episodes, sleep disorders and increased body weight. Overall behavioral disorders were more common in children who experienced headache than in controls. A significant association of primary headache was found with anxiety and depression (p value <0.001), but not with the other psychiatric disorders. Primary headaches in children are not associated with most of the psychiatric and systemic conditions herein investigated. On the contrary, there was a significant association with anxiety and depression, as frequently reported in adults.Recurrent headaches are very widespread and disabling conditions in children. Although most cases follow a benign course, they cause substantial worry in parents and caregivers. The diagnosis of primary and secondary headache disorders is based upon the history of headaches, a careful physical and neurological examination, and in some cases, neurological investigations.Recurrent, episodic and paroxysmal attacks are suggestive of primary headache disorders, which have been subdivided into migraines, tension-type headaches (TTHs), cluster headaches, and other (uncommon) types in children. Migraines are further subdivided into migraines with and without auras, complicated migraines and migraine variants (1-3). Migraines have been estimated to affect nearly 75% of children under the age of 15 years and have been reported in 3.9% of children between the ages of 7 and 15 years, with a range from 1.7% in 7-yearold children to 5% in l5-year-old children (3-4).

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“…20,65 Overweight females had a near four fold excess risk of headache when compared to normal-weight girls; there was no relationship between weight and headache in males. 66 …”

Section: Obesitymentioning

confidence: 99%

Chronic Daily Headache in Children and Adolescents: A Multi-Faceted Syndrome

Seshia

Wang

Abu‐Arafeh

et al. 2010

Can. j. neurol. sci.

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In 1982, Mathew et al first used the term "chronic daily headache" (CDH) to describe headaches that occurred almost daily in adults. 1 Twelve years later, Holden et al published the first report on children with CDH. 2 Since then, there have been at least 21 reports globally. Cumulative knowledge suggests that CDH is not only a common chronic pain syndrome in children (the term will be used to include adolescents), but also a multi-faceted, and often complex one. The appreciation of the many aspects of CDH is pivotal to clinical research and management, and is the thrust of our review. DEFINITIONS AND CLASSIFICATION: THE CONTINUING CONTROVERSY BackgroundIn the almost 30 years since the original description, CDH continues to evoke passionate debate. Globally accepted criteria ABSTRACT: Chronic daily headache (CDH) is a multi-faceted, often complex pain syndrome in children and adolescents. Chronic daily headache may be primary or secondary. Chronic migraine and chronic tension-type are the most frequent subtypes. Chronic daily headache is co-morbid with adverse life events, anxiety and depressive disorders, possibly with other psychiatric disorders, other pain syndromes and sleep disorders; these conditions contribute to initiating and maintaining CDH. Hence, early management of episodic headache and treatment of associated conditions are crucial to prevention. There is evidence for the benefit of psychological therapies, principally relaxation and cognitive behavioral, and promising information on acupuncture for CDH. Data on drug treatment are based primarily on open label studies. The controversies surrounding CDH are discussed and proposals for improvement presented. The multifaceted nature of CDH makes it a good candidate for a multi-axial classification system. Such an approach should facilitate biopsychosocial management and enhance consistency in clinical research.RÉSUMÉ: La céphalée quotidienne chronique chez les enfants et les adolescents, un syndrome à multiples facettes. La céphalée quotidienne chronique (CQC) est un syndrome douloureux à multiples facettes qui est souvent complexe chez les enfants et les adolescents. La céphalée quotidienne chronique peut être primaire ou secondaire. La migraine chronique et la céphalée de tension chronique sont les sous-types les plus fréquents. La CQC est une comorbidité des incidents fâcheux de la vie, de l'anxiété et des troubles dépressifs, possiblement liée à d'autres troubles psychiatriques, syndromes douloureux et troubles du sommeil. Ces états contribuent à amorcer et à maintenir la CQC. Le traitement précoce de la céphalée épisodique et le traitement des comorbidités est donc crucial pour la prévention. Certaines données démontrent un bénéfice des psychothérapies, principalement de la relaxation et de la thérapie cognitivo-comportementale, et l'acuponcture pour le traitement de la CQC semble prometteuse. Les données sur le traitement médicamenteux sont basées principalement sur des études ouvertes. Nous discutons des controverses entourant la CQC et des mo...

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Headaches in Overweight Children and Adolescents Referred to a Tertiary‐care Center in Israel

Cited by 64 publications

References 24 publications

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Primary Headaches in Children: Clinical Findings and the Association with other Conditions

Chronic Daily Headache in Children and Adolescents: A Multi-Faceted Syndrome

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