Headache, migraine and cardiovascular risk factors: The HUNT study

Winsvold, Bendik S.; Hagen, Knut; Aamodt, Anne Hege; Stovner, Lars Jacob; Holmen, Jostein; Zwart, John‐Anker

doi:10.1111/j.1468-1331.2010.03199.x

Cited by 86 publications

(119 citation statements)

References 34 publications

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“…Two studies included predominantly older participants (mean participant age .50 years 12,23 ) and the rest predominantly younger participants (n 5 10). Five studies reported sexstratified analyses, 5,6,13,14,22 2 studies adjusted for sex only as a classic confounder, 2,23 4 studies were conducted in women alone, 3,9,12,24 and 1 study included both sexes did not adjust or stratify for sex. 25 The majority of the studies utilized self-reported height and weight to estimate obesity status (n 5 8 2,3,6,9,12,13,22,24 ) and half utilized self-report of non-International Classification of Headache Disorders (ICHD) classification of migraine (n 5 6 2,3,9,12, 14,22 ).…”

Section: Resultsmentioning

confidence: 99%

“…1,4 In the extant literature of studies examining the migraine-obesity association, population inclusion criteria have varied by important modifiers of both disorders, most notably age and sex. While some studies included adults of all ages, [5][6][7] others were limited to younger 3,8,9 or older [10][11][12] populations, whereas others stratified by age (e.g., ,50 and $50 years). 13,14 Likewise, some studies included both men and women (combined or stratified), 1 whereas others were limited to only women.…”

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confidence: 99%

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Body composition status and the risk of migraine

et al. 2017

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Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories.Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model. Significant values, weighted effect sizes, and tests of homogeneity of variance were calculated.Results: A total of 12 studies, encompassing data from 288,981 unique participants, were included. The age-and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.16-1.37, p , 0.001) and remained increased after multivariate adjustments. Although the age-and sex-adjusted pooled migraine risk was increased in overweight individuals (OR 1.08; 95% CI 1.04, 1.12, p , 0.001), significance was lost after multivariate adjustments. The age-and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight (OR 1.13; 95% CI 1.02, 1.24, p , 0.001) and remained increased after multivariate adjustments. Conclusions:The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine. Both migraine and obesity are conditions associated with substantial personal and societal burdens.1 As obesity is a potentially modifiable risk factor, the relationship between migraine and obesity has been a focus of research interest for the last decade. [1][2][3] Although several studies support that obesity is associated with an increased risk of migraine, results are inconsistent with regards to included populations, how obesity status is categorized, and other features of individual study design and conduct, and the conclusions drawn.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Body composition status and the risk of migraine

et al. 2017

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“…2 Some studies also suggest that migraine is associated with an unfavorable cardiovascular risk profile, cardiovascular disease events, and vascular death. [3][4][5][6][7][8] However, there are no reliable indicators to predict which migraineurs will develop cerebrovascular ischemic insults and other vascular events. Moreover, migraine may be a potentially modifiable vascular risk factor, requiring further exploration in high-risk populations.…”

Section: Discussionmentioning

confidence: 99%

Migraine and risk of stroke in older adults

et al. 2015

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Objective: To examine the association between migraine and stroke/vascular outcomes in a racially/ethnically diverse, older cohort.Methods: Participants from the Northern Manhattan Study, a population-based cohort study of stroke incidence, were assessed for migraine symptoms using a self-report questionnaire based on criteria from the International Classification of Headache Disorders, second edition. We estimated the association between migraine and combined vascular events including stroke and stroke only over a mean follow-up of 11 years, using Cox models adjusted for sociodemographic and vascular risk factors.Results: Of 1,292 participants (mean age 68 6 9 years) with migraine data followed prospectively for vascular events, 262 patients (20%) had migraine and 75 (6%) had migraine with aura. No association was found between migraine (with or without aura) and risk of either stroke or combined cardiovascular events. There was an interaction between migraine and current smoking (p 5 0.02 in relation to stroke and p 5 0.03 for combined vascular events), such that those with migraine and smoking were at an increased risk. The hazard ratio of stroke for migraine among current smokers was 3.17 (95% confidence interval [CI] 1.13-8.85) and among current nonsmokers was 0.77 (95% CI 0.44-1.35). In relation to combined vascular events, the hazard ratio for migraine vs no migraine among current smokers was 1.83 (95% CI 0.89-3.75) and among current nonsmokers was 0.63 (95% CI 0.43-0.94). Conclusion:In our racially/ethnically diverse population-based cohort, migraine was associated with an increased risk of stroke among active smokers but not among nonsmokers. Migraine is a complex neurovascular syndrome resulting in an unstable trigeminal vascular system. It has been suggested that migraine and stroke exist on a continuum, and the vascular system may have important secondary consequences in migraine.1 While the vascular theory of migraine has been disproved, migraine with aura, mostly in women younger than 45 years, has been shown to be an independent risk factor for ischemic stroke.2 Some studies also suggest that migraine is associated with an unfavorable cardiovascular risk profile, cardiovascular disease events, and vascular death.3-8 However, there are no reliable indicators to predict which migraineurs will develop cerebrovascular ischemic insults and other vascular events. Moreover, migraine may be a potentially modifiable vascular risk factor, requiring further exploration in high-risk populations.The objective of this study was to assess the association between migraine, including both migraine with and without aura, and stroke in the Northern Manhattan Study (NOMAS), an ethnically diverse, older, community-based cohort. As a secondary aim, we also explored the association between migraine and vascular events/mortality.

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“…In the study of Ozdemir et al [24] concerning lipid levels in children with epilepsy, a slightly lower level of total cholesterol was also observed in the study group than in controls. In adults suffering from migraine lower total cholesterol and HDL cholesterol levels were demonstrated when compared to non-migrainous headaches sufferers [25]. In contrast to the widely known risk related to a high cholesterol level, some recent studies reported that low total cholesterol levels may be associated with higher risk of mortality due to haemorrhagic stroke and heart failure in adults [26].…”

Section: Discussionmentioning

confidence: 90%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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Headache, migraine and cardiovascular risk factors: The HUNT study

Abstract: Both MA, MO and non-migrainous headache are associated with an unfavourable cardiovascular risk profile, but different mechanisms seem to underlie the elevated risk in MA than in the other headache types.

Cited by 86 publications

References 34 publications

Body composition status and the risk of migraine

Body composition status and the risk of migraine

Migraine and risk of stroke in older adults

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

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