Headache and adverse pregnancy outcomes: a prospective study

Marozio, Luca; Facchinetti, Fabio; Allais, Gianni; Nappi, Rossella E.; Enrietti, M.; Neri, Isabella; Picardo, Elisa; Benedetto, Chiara

doi:10.1016/j.ejogrb.2011.12.030

Cited by 37 publications

(26 citation statements)

References 18 publications

(25 reference statements)

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“…Another potential confounder is concomitant medication use, particularly in the migraine no‐triptans group. Some of these medications are known to be associated with preterm birth, and depression in particular is often present in patients suffering from migraines …”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta‐Analysis

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta‐Analysis

et al. 2015

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“…Our results largely agree with previous studies examining selected birth outcomes in pregnant women with migraine. Earlier studies found a 1.2‐3.2‐fold increased risk of low birth weight, while results have been contradictory for risks of preterm birth (0.6‐2.7‐fold increased risk), small for gestational age offspring (0.77‐1.07‐fold increased risk), and cesarean delivery (0.94‐1.16‐fold increased risk) . However, only 1 of 5 previous studies found a decreased risk of preterm birth .…”

Section: Discussionmentioning

confidence: 93%

“…2,7,8 Migraine in pregnancy is associated with adverse outcomes in mother and offspring, including pregnancy-associated hypertensive disorders, [9][10][11][12][13] low birth weight, [9][10][11]13,14 and preterm birth. [9][10][11][13][14][15] Associations with other pregnancy and birth outcomes such as placenta previa, gestational diabetes, miscarriage, stillbirth, small for gestational age offspring, cesarean delivery, or birth defects have been less studied. [9][10][11]13,[15][16][17] Nevertheless, most previous studies included fewer than 1000 migraine patients.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][13][14][15] Associations with other pregnancy and birth outcomes such as placenta previa, gestational diabetes, miscarriage, stillbirth, small for gestational age offspring, cesarean delivery, or birth defects have been less studied. [9][10][11]13,[15][16][17] Nevertheless, most previous studies included fewer than 1000 migraine patients. 9,[11][12][13][14][15][16][17] One large register-based study included 4911 migraine patients, but only selected patients with at least 3 consensus migraine diagnoses, which may have led to restriction of patients with relatively severe disease.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine

et al. 2019

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Background Prevalence of migraine is high during the reproductive age. Although migraine often improves during pregnancy, the risk of adverse pregnancy, birth, neonatal, and neurological outcomes in mother and offspring remains poorly understood. Objective To investigate the associations between maternal migraine and risks of adverse pregnancy outcomes in the mother, and birth, neonatal and postnatal outcomes in the offspring. Methods We used Danish population registries to assemble a cohort of pregnancies among women with migraine and an age‐ and conception year‐matched comparison cohort of pregnancies among women without migraine. The study period was 2005‐2012. We computed adjusted prevalence ratios (aPRs) for pregnancy and birth outcomes and adjusted risk ratios (aRRs) for neonatal and postnatal outcomes, adjusting for age, preconception medical history, and preconception reproductive history. Results We identified 22,841 pregnancies among women with migraine and 228,324 matched pregnancies among women without migraine. Migraine was associated with an increased risk of pregnancy‐associated hypertension disorders (aPR: 1.50 [95% confidence interval (CI): 1.39‐1.61]) and miscarriage (aPR: 1.10 [95% CI: 1.05‐1.15]). Migraine was associated with an increased prevalence of low birth weight (aPR: 1.14 [95% CI: 1.06‐1.23]), preterm birth (aPR: 1.21 [95% CI: 1.13‐1.30]) and cesarean delivery (aPR: 1.20 [95% CI: 1.15‐1.25]), but not of small for gestational age offspring (aPR: 0.94 [95% CI: 0.88‐0.99]) and birth defects (aPR: 1.01 [95% CI: 0.93‐1.09]). Offspring prenatally exposed to maternal migraine had elevated risks of several outcomes in the neonatal and postnatal period, including intensive care unit admission (aRR: 1.22 [95% CI: 1.03‐1.45]), hospitalization (aRR: 1.12 [95% CI: 1.06‐1.18]), dispensed prescriptions (aRR: 1.34 [95% CI: 1.24‐1.45]), respiratory distress syndrome (aRR: 1.20 [95% CI: 1.02‐1.42]), and febrile seizures (aRR: 1.27 [95% CI: 1.03‐1.57), but not of death (aRR: 0.67 [95% CI: 0.43‐1.04]) and cerebral palsy (aRR: 1.00 [95% CI: 0.51‐1.94]). Conclusions Women with migraine and their offspring have greater risks of several adverse pregnancy outcomes than women without migraine.

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“…Estimates of lifetime prevalence of migraine among pregnant women range from 9–20% (Adeney et al, 2006; Frederick et al, 2014). Several studies have reported higher frequencies of preterm delivery, low birth weight, placental abruption, preeclampsia, and other hypertensive disorders among pregnant migraineurs when compared to pregnant non-migraineurs (Adeney and Williams, 2006; Chen et al, 2010; Marozio et al, 2012; Sanchez et al, 2010; Williams et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety and stress among pregnant migraineurs in a pacific-northwest cohort

Orta

Gelaye

Qiu

et al. 2015

Journal of Affective Disorders

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Background The co-occurrence of migraine and unipolar psychiatric disorders has been well documented in non-pregnant populations, however little is known in pregnant populations. Methods A cohort of 1,321 women was interviewed during the first trimester of pregnancy. At the time of interview lifetime migraine status was ascertained using International Classification of Headache Disorders diagnostic criteria (ICHD-II). Information regarding unipolar depression, anxiety and stress during pregnancy was collected using the Patient Health Questionnaire Depression Module-9 (PHQ-9), and the Depression Anxiety Stress Scales 21-item Short Form (DASS-21). Multivariable logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of migraine and mood disorders during pregnancy. Results Approximately 28.2% (N=372) were classified as having a lifetime history of migraine; among migraineurs 122 were classified as migraineurs with aura and 250 as migraineurs without aura. Compared with non-migraineurs, migraineurs were associated with 1.60-fold increased odds of depression as measured by a PHQ-9 score ≥10 (AOR=1.60; 95% CI: 1.12–2.31). Overall, migraine with aura was more strongly associated with depression than was migraine without aura. Migraineurs, as compared with non-migraineurs, also had higher odds of mood disorders as measured by the DASS-21. Conclusions The comorbidity of mood and migraine disorders in pregnant populations supports the need for integrated mental and physical clinical evaluation, increased vigilance, and treatment of patients with such disorders.

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Headache and adverse pregnancy outcomes: a prospective study

Abstract: Women with headache should be considered at risk for adverse perinatal outcomes and should, therefore, be included in a high-risk pregnancy protocol of care throughout pregnancy.

Cited by 37 publications

References 18 publications

Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta‐Analysis

Pregnancy Outcome Following Prenatal Exposure to Triptan Medications: A Meta‐Analysis

Pregnancy, Birth, Neonatal, and Postnatal Neurological Outcomes After Pregnancy With Migraine

Depression, anxiety and stress among pregnant migraineurs in a pacific-northwest cohort

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