Head and Neck Soft Tissue Sarcomas: A Multivariate Analysis of Outcomes

Bentz, Brandon G.; Singh, Bhuvanesh; Woodruff, James M.; Brennan, Murray F.; Shah, Jatin P.; Kraus, Dennis H.

doi:10.1245/aso.2004.03.006

Cited by 101 publications

(144 citation statements)

References 24 publications

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“…Although tumor resection should be the objective of surgery, our series, along with other reports, indicates that negative surgical margins are achieved in <50% of patients. 1 This high positive margin rate may be related to the biologic behavior of SBS and its proximity to the brain, dura and carotid artery, cavernous sinus, and orbit. However, this rate is higher than that reported for other anterior skull base malignancies.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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BACKGROUND. Single‐institutional studies lack sufficient power to assess the role of surgery and radiotherapy in the management of sarcomas involving the anterior skull base. For this study, an international collaborative study group analyzed a large cohort of patients who underwent surgery for the treatment of skull base tumors. METHODS. A subset of 146 patients who had a histologic diagnosis of skull base sarcoma (SBS) formed the basis of this report. Most patients were aged ≥21 years (77%) and had stage IV disease (56%). Adjuvant radiotherapy was received by 35% of patients, and chemotherapy was received by 10% of patients. RESULTS. Orbital involvement was encountered in 53% of patients, involvement of the orbital wall was encountered in 46% of patients, and intracranial extension was encountered in 28% of patients. Positive microscopic margins were reported in 43% of patients (51 of 118 patients). Treatment‐related complications were reported in 27% of patients, and postoperative mortality was reported in 1.4% of patients. With a median follow‐up of 34 months, the 5‐year overall, disease‐specific, and recurrence‐free survival rates were 62%, 64%, and 57%, respectively. Tumor grade and adjuvant radiotherapy were not significant predictors of survival. Prior radiotherapy, intraorbital extension, positive margins, and postoperative complications were significant predictors of reduced disease‐specific survival on univariate analysis. The presence of positive/close margins, however, was the only independent predictor of poor overall, recurrence‐free, and disease‐specific survival on multivariate analysis (relative risk, 2.4; P = .006). The 5‐year disease‐specific survival rate was 77%, 43%, and 36% for patients with negative, close, and positive margins, respectively. CONCLUSIONS. The current results indicated that wide craniofacial resection with negative margins is an independent prognostic predictor of better outcome. Patients with positive margins have a high risk for tumor recurrence independent of tumor grade. Cancer 2007. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

“…STS are found infrequently in the mature population, in which they account for 10% of all sarcomas [1][2][3] and only 1% of head and neck tumors. 4 These tumors are more common in childhood, and up to 33% occur in the head and neck region.…”

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confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

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“…[4] Undifferentiated high-grade pleomorphic sarcoma is currently a diagnosis of exclusion and represents 5% of soft tissue sarcomas in adults. [2,8] It is a soft tissue sarcoma composed of undifferentiated mesenchymal cells.…”

Section: Published By Sciedu Pressmentioning

confidence: 99%

“…[1] It usually occurs in extremities, being more common in lower extremities. [4] Its location in the head and neck is rare, with an incidence of 4% to 10%. The most frequent location in head and neck is the neck and parotid gland, followed by the scalp, face, anterior skull base and orbit, there are few reports in upper aerodigestive tract, lateral skull base and ears.…”

Section: Published By Sciedu Pressmentioning

confidence: 99%

“…[2] The location in the head and neck is very rare with an incidence of 4% to 10%, being the most frequent sites the neck and the parotid gland. [4] Clinically they are presented as a mass of progressive and rapid growth that may be associated with pain of the compromised site. Histologically they present a heterogeneous cell pattern with pleomorphism and aberrant giant cells with nonspecific immunohistochemical markers due to the lack of cellular differentiation, being only positive for vimentin.…”

Section: Introductionmentioning

confidence: 99%

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Maxillary undifferentiated high-grade pleomorphic sarcoma: A case report and review of the literature

Sepulveda

Compañ

Ulloa

et al. 2016

CRCP

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Head and Neck Soft Tissue Sarcomas: A Multivariate Analysis of Outcomes

Abstract: Size >5 cm and high-grade histology are considered poor prognostic indicators. Patients with either of these characteristics should be considered for adjuvant trials.

Cited by 101 publications

References 24 publications

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Maxillary undifferentiated high-grade pleomorphic sarcoma: A case report and review of the literature

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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