Head and neck sarcomas: A single institute series

Vassiliou, Leandros; Lalabekyan, Bagrat; Jay, Amrita; Liew, Colin; Whelan, Jeremy; Newman, Laurence; Kalavrezos, Nicholas

doi:10.1016/j.oraloncology.2016.12.005

Cited by 28 publications

(22 citation statements)

References 32 publications

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“…They contain eosinophilic cells that are arranged in nests and cords with hemorrhage in some areas [ 37 ]. Osteosarcomas seldom grow in a lobular pattern, and have much more cytologic atypia and pleomorphism than the malignant form of OFMT [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Velasco

Zhang

et al. 2018

Diagn Pathol

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BackgroundOssifying fibromyxoid tumor of soft parts (OFMT), is a rare but morphologically distinctive neoplasm of uncertain histogenesis that most frequently affects middle-aged male adults. Clinically, it usually presents as a slowly enlarging, small, circumscribed mass, which in most cases is painless. OFMT is most frequently found within the subcutaneous tissues of extremities or trunk, and rarely in the oral/head and neck region. We present an unusual case of this tumor in the submandibular region, and, based on the current medical literatures this is probably the first case described in this anatomical location.Case presentationA 32-year-old male presented to our outpatient clinic with a right submandibular mass with 1-year of evolution. Excisional biopsy showed that it was characterized by ossification along the periphery of the lesion. The neoplastic cells were spindle-like with scant eosinophilic cytoplasm. These cells were arranged with uniform cell-to-cell space in a fibromyxoid stroma. Small and large clusters of calcifications were present within the tumor. Immunohistochemically, the case showed positive staining of S-100 protein, vimentin, nestin, calponin, SMA, GFAF, desmin, INI-1, caldesmon, and CD34. It also showed negative staining of CK, CK7, CK8/18, NF, and EMA. About 2% of neoplastic cells showed positive staining of Ki67. Based on these features, the final pathological diagnosis was OFMT.ConclusionsIt is hoped that a greater understanding of OFMT in the head and neck region will avoid potential misdiagnosis, and contribute to determining the correct management, which appears to be complete surgical excision with close follow-up for recurrence surveillance.

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Section: Discussionmentioning

confidence: 99%

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Velasco

Zhang

et al. 2018

Diagn Pathol

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“…A follow‐up resection may be required . Vassiliou et al . argued that a simplistic geometrical approach of margin measurement in such a complex region as the head and neck is not easily applicable.…”

Section: Principles Of Management Of Head and Neck Htsmentioning

confidence: 99%

“…argued that a simplistic geometrical approach of margin measurement in such a complex region as the head and neck is not easily applicable. Margins are more likely to be achieved when performing a wide excision with large bony margins and complete excision of the surrounding soft tissue . The removal of the anatomical compartment also needs to encompass the bone marrow.…”

Section: Principles Of Management Of Head and Neck Htsmentioning

confidence: 99%

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Current update on the diagnosis and management of head and neck hard tissue sarcomas

Tudor-Green

Fonseca

Gomez

et al. 2017

J Oral Pathology Medicine

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Head and neck hard tissue sarcomas form a rare group of mesenchymal-derived tumours that comprise less than 1% of all head and neck neoplasms. Hard tissue sarcomas account for 20% of head and neck sarcomas and they form a heterogeneous group with a diverse origin. Unlike head and neck soft-tissue sarcomas, they have lower recurrence and mortality rates. In this study, we review the current management of head and neck hard tissue sarcomas.

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“…Recently, treatment of osteosarcoma has been improved by performing radical surgery. In addition, neoadjuvant chemotherapy increases 5-year overall survival from 30% to about 70% to 80% [ 4 – 6 ]. Although the survival rate has risen over the past decades, it is unsatisfactory and the prognosis for osteosarcoma patients with metastatic lesions is still poo.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells

Jiang

Huang

2020

Med Sci Monit

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Background Curcumin derivative C086 (cur C086) is a potential chemotherapeutic agent for patients with osteosarcoma. In this study, the effects of cur C086 combined with cisplatin on the biological processes of osteosarcoma cells were investigated. Material/Methods In this study, expression of BMIL1 was detected by real-time quantitative reverse transcription polymerase chain reaction and Western blotting in MG-63 cells treated with cur C086+cisplatin. Functions of cur C086+cisplatin on proliferation ability, apoptosis response, and metastatic potential of MG-63 cells were determined by MTT, flow cytometry, Hoechst 33258 staining and Transwell assays, respectively. In additionally, expression of P16, E-cadherin, epidermal growth factor (EGFR), and Notch1 was measured by Western blotting. Results Expression of BMIL1 decreased significantly in MG-63 cells treated with cur C086 (20 μM)+cisplatin (1.28 nM). Treatment with cur C086+cisplatin considerably inhibited growth, migration, and invasion potential in MG-63 cells, whereas apoptosis was obviously upregulated. Moreover, cur C086+cisplatin suppressed BMIL1 expression or its potential downstream targets, P16, E-cadherin, EGFR, and Notch1. Conclusions The current results demonstrate that combined treatment with cur C086+cisplatin may be an effective form of chemotherapy for patients with osteosarcoma.

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Head and neck sarcomas: A single institute series

Cited by 28 publications

References 32 publications

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review

Current update on the diagnosis and management of head and neck hard tissue sarcomas

Curcumin Derivative C086 Combined with Cisplatin Inhibits Proliferation of Osteosarcoma Cells

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