Current update on the diagnosis and management of head and neck hard tissue sarcomas

Tudor-Green, Ben; Fonseca, Felipe Paiva; Gomez, Ricardo Santiago; Brennan, Peter A.

doi:10.1111/jop.12573

Cited by 9 publications

(18 citation statements)

References 73 publications

(101 reference statements)

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“…Previous studies that included a larger cohort of 12,755 patients mentioned that further data accumulation for predictors of HNS due to rare tumors and various histological subtypes is needed [1][2][3]. Indeed, Ketabachi et al had reported that the surgical margin was a survival predictor for 25 patients with HNS [7].…”

Section: Discussionmentioning

confidence: 99%

“…HNSs have been divided into those of the bone and those of the soft tissue [1,2]. Although the TNM staging system has been broadly accepted as a useful predictor for various malignant tumors, there remains a lack of clari cation for soft tissue sarcomas of the head and neck in the staging system outlined in the eighth edition of the UICC TNM classi cation [13].…”

Section: Discussionmentioning

confidence: 99%

“…Head and neck sarcoma (HNS) is a rare malignancy, with more than 50 pathological subtypes, accounting for approximately 1% of all head and neck malignancies [1,2]. Surgery is the main treatment for patients who are newly diagnosed with HNS, while the e cacy of chemotherapy or radiotherapy remains debatable for all pathological subtypes of HNS [1][2][3]. The predictors for survival outcomes of HNS, such as overall survival, have been investigated by several previous studies [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Age for Overall Survival in Head and Neck Sarcoma

Suzuki¹,

Takano²,

Tsukushi³

et al. 2020

Preprint

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Background：The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS. Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence). Conclusion: Older age predicts worse overall survival in HNS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Age for Overall Survival in Head and Neck Sarcoma

Suzuki¹,

Takano²,

Tsukushi³

et al. 2020

Preprint

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“…However, surgical intervention with wide excision of the neoplasm and the achievement of clear margins is generally paramount in the treatment of adult patients with head and neck sarcoma . In the case of high‐grade sarcomas, when surgical intervention with a wide excision is not possible or when facing unclear margins after surgical intervention, adjuvant therapeutic intervention in terms of RT, chemotherapy, or a combination should be recommended . The radiosensitivity and chemosensitivity are, however, highly dependent upon the histologic subtype and the patient's age .…”

Section: Discussionmentioning

confidence: 99%

“…In the case of high‐grade sarcomas, when surgical intervention with a wide excision is not possible or when facing unclear margins after surgical intervention, adjuvant therapeutic intervention in terms of RT, chemotherapy, or a combination should be recommended . The radiosensitivity and chemosensitivity are, however, highly dependent upon the histologic subtype and the patient's age . Importantly, microscopically incomplete tumor resection has been shown to reduce OS and local control of sinonasal soft tissue sarcomas .…”

Section: Discussionmentioning

confidence: 99%

Sarcomas of the sinonasal tract

et al. 2018

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Outcomes of microvascular bone flaps versus osteocutaneous flaps in head and neck reconstruction

et al. 2020

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Background: Surgical resection of head and neck (H&N) neoplasms requiring osseous reconstruction have underdefined complication profiles. This study aimed to characterize postoperative outcomes of patients with H&N neoplasia undergoing osteocutaneous flap (OCF) or bare bone flap (BBF) reconstructions. Materials and methods: Retrospective analysis of the National Surgical Quality Improvement Program (NSQIP) 2005-2017 databases. Queried for diagnosis and procedural codes extracted patients with H&N neoplasms undergoing BBF or OCF reconstruction. Postoperative complications were evaluated. Multivariable regression generated adjusted odds ratios. Results: A cohort of 746 patients were identified. Of reconstructions, 24.9% (n = 186/746) were BBFs while 75.1% (n = 560/746) were OCFs. 58.1% of the BBF cohort and 59.9% of the OCF cohort experienced an all-cause complication (p = .654). Sub-stratified, 24.2% of BBF and 17.5% of OCF patients experienced a wound complication (p = .045). Regression analysis demonstrated no difference in risk for medical complications between cohorts. However, patients receiving OCFs had a decreased likelihood of developing a wound complication (OR 0.652; 95%CI 0.430-0.989; p = .044) compared to patients receiving BBFs. Conclusion: The incidence of complications following osseous reconstruction of the H&N is considerable. Although several complication outcomes do not seem to differ between BBF or OCF reconstructions, OCFs is associated with a decreased likelihood of wound complications. 1 | INTRODUCTION Benign and malignant neoplasms of the head and neck (H&N) exert significant global morbidity with H&N cancer occurring in more than 500,000 patients across the globe each year (Jemal et al., 2011). An estimated 65,000 of these new cases are annually diagnosed in the United States, of which 14,000 result in death (Cancer.net Editorial Board, n.d.). These statistics are further magnified by cutaneous malignancies localized to the H&N (Mydlarz, Weber, & Kupferman, 2015). Ultimately, the treatment of H&N neoplasms is multi-faceted and interdisciplinary involving medical, surgical, occupational, and psychological support (Wheless, McKinney, & Zanation, 2010). Surgical intervention is an integral aspect of H&N tumor management with excision dependent upon tumor location and characteristics (Carlson & McCoy, 2017; Fu, Foreman, Goldstein, & de Disclaimer: The ACS NSQIP databases are the source of information used in this study. Data extrapolated, statistical analysis performed, and conclusions reached have not been verified by the ACS NSQIP but rather are the result of the work done by authors of this study.

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Current update on the diagnosis and management of head and neck hard tissue sarcomas

Cited by 9 publications

References 73 publications

Impact of Age for Overall Survival in Head and Neck Sarcoma

Impact of Age for Overall Survival in Head and Neck Sarcoma

Sarcomas of the sinonasal tract

Outcomes of microvascular bone flaps versus osteocutaneous flaps in head and neck reconstruction

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