Head and Neck Lymphomas Associated With Human Immunodeficiency Virus Infection

Carbone, Antonino; Vaccher, Emanuela; Barzan, Luigi; Gloghini, Annunziata; Volpe, Rachele; Re, Vallì De; Boiocchi, Mauro; Monfardini, S.; Tirelli, Umberto

doi:10.1001/archotol.1995.01890020072014

Cited by 19 publications

(13 citation statements)

References 36 publications

(14 reference statements)

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“…The most common sites include palate, retromolar pad, tonsillar pillars and tongue (Green & Eversole, 1989). However, most HIV patients presented with oral non-Hodgkin's lymphoma may already have nodal and extranodal involvement at the time of diagnosis (Carbone et al, 1995). Patients with localized disease are treated with radiotherapy.…”

Section: Non-hodgkin's Lymphomamentioning

confidence: 99%

“…However, chemotherapy can induce profound neutropenia which can be treated effectively with concomitant administration of granulocyte-macrophage colony-stimulating factor (Kaplan et al, 1991). Complete remission occurs in approximately 65% of patients with the median survival time between 4 and 11 months (Carbone et al, 1995). Low CD4+ count and involvement of bone and extranodal site indicate poor prognosis (Levine et al, 1991).…”

Section: Non-hodgkin's Lymphomamentioning

confidence: 99%

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Oral Health-Related Quality of Life Among People Living with HIV/AIDS

Saddki¹,

Mohamad²

2011

HIV-infection - Impact, Awareness and Social Implications of Living With HIV/AIDS

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Section: Non-hodgkin's Lymphomamentioning

confidence: 99%

Section: Non-hodgkin's Lymphomamentioning

confidence: 99%

Oral Health-Related Quality of Life Among People Living with HIV/AIDS

Saddki¹,

Mohamad²

2011

HIV-infection - Impact, Awareness and Social Implications of Living With HIV/AIDS

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“…Mittlerweile liegen Studien mit größeren Patientenkollektiven von HIV-NHL im Kopf-Hals-Bereich vor [2,4,18]. Laut Carbone treten 38,4% (28/73) der NHL bei AIDS-Patienten in dieser Region auf [2]. Dem HNO-Arzt kommt aus diesem Grund vor allem bei der Diagnostik eine besondere Bedeutung zu.…”

Section: Ergebnisseunclassified

“…Bei Patienten mit angeborenem oder erworbenem Immundefekt sind vermehrt Malignome zu beobachten [2,13,17,18]. Durch die Entwicklung der damit verbundenen Lymphomproliferation ist die Häufigkeit, an hochmalignen Non-Hodgkin-Lymphomen zu erkranken, erhöht.…”

Section: Diskussionunclassified

“…Da sich etwa 40% der Infizierten erstmals mit Symptomen im Kopf-Hals-Bereich vorstellen, kommt dem HNO-Arzt eine entscheidende Bedeutung bei der Diagnostik der HIV-Infektion und der begleitenden Erkrankungen zu [2,4,9]. Neben Candidiasis, Lymphadenopathie und Haarleukoplakie wird der HNOArzt, bedingt durch das längere Über-leben der Infizierten, künftig in zunehmendem Maße auch mit HIVbedingten Malignomen wie dem Kaposi-Sarkom und dem meist als rasch wachsender Tumor imponierenden HIV-NHL konfrontiert werden [4,9,13,18].…”

Section: Schlußfolgerungunclassified

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HIV-assoziierte Non-Hodgkin-Lymphome (HIV-NHL) im Kopf-Hals-Bereich

Riederer

Dreher

Zietz

et al. 1997

HNO

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The life span of HIV-infected patients has increased because of anti-retroviral therapy and improved means for treating opportunistic infections. However, HIV infection and subsequent immunosuppression result in an increased risk of high-grade B-cell lymphomas. The purpose of this study was to determine the incidence, localization, clinical features, therapy and survival time of patients with HIV-related lymphomas of the head and neck. Between 1988 and 1995, 280 HIV-infected patients presented with otolaryngologic symptoms. Seventy-two (25.7%) were found to have a neoplastic disease. Fifty-six of these patients (20%) were diagnosed as having Kaposi's sarcoma and 12 (4.3%) had lymphomas. According to the Kiel classification, lymphomas were subdivided into Hodgkin's disease (2 cases) and B-cell lymphomas of high-grade malignancy (10 cases). These latter cases were centroblastic (n = 4), Burkitt's type (n = 4), anaplastic large cell (n = 1) and not classifiable (n = 1). All patients with HIV-related non-Hodgkin's lymphomas (NHL) were men and 8 were homosexuals. The mean age was 36.1 years. In addition to 7 nodal locations, high-grade B-cell lymphomas were found in the oropharynx (n = 2) and palate (n = 1). Four patients underwent chemotherapy, 1 patient underwent radiation therapy and 2 were treated with both methods. Two patients did not receive any treatment and 1 patient underwent laser therapy. The survival time depended on the previous diagnosis of AIDS, the patients' immune status and the karnofsky index. In 2 patients the lymphoma led to the diagnosis of HIV infection. Our findings show that any solitary or enlarging tumors or ulcerating lesions in the head and neck region of HIV patients must be examined histologically to exclude HIV-NHL. We also recommend that young patients with high-grade B-cell lymphomas should undergo HIV screening.

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