Head and neck: Laryngeal tumors: an overview

Mastronikolis, N.S.; Papadas, Theodoros; Goumas, Panos; Triantaphyllidou, Irene-Eva; Theocharis, Dimitrios A.; Papageorgakopoulou, N.; Vynios, Demitrios H.

doi:10.4267/2042/44625

Cited by 17 publications

(28 citation statements)

References 15 publications

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“…About 50-60% of laryngeal squamous cell carcinomas (SCC) arise from the glottic region [1] and over 80% of these patients present in an early stage [2]. The larynx has important roles in production of voice, coordination of deglutition, and respiration.…”

Section: Schlüsselwörter Plattenepithelkarzinom • Larynxneoplasien • mentioning

confidence: 99%

T1–2 glottic cancer treated with radiotherapy and/or surgery

et al. 2017

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Section: Schlüsselwörter Plattenepithelkarzinom • Larynxneoplasien • mentioning

confidence: 99%

T1–2 glottic cancer treated with radiotherapy and/or surgery

et al. 2017

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“…The initiation and progression of HNC is a rather complex multistep process involving genetic and epigenetic changes. The most common histological subtype of HNC is referred to head and neck squamous cell carcinoma (HNSCC) [3] and laryngeal squamous cell carcinoma (LSCC) [4,5]. Tobacco smoking, alcohol consumption and human papilloma virus (HPV) infections are the most common risk factors.…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours

Cossu

Mosca

Zappavigna

et al. 2019

IJMS

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Head and neck carcinoma (HNC) is a heterogeneous disease encompassing a variety of tumors according to the origin. Laryngeal cancer (LC) represents one of the most frequent tumors in the head and neck region. Despite clinical studies and advance in treatment, satisfactory curative strategy has not yet been reached. Therefore, there is an urgent need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as suitable therapeutic targets. Long non-coding RNAs (lncRNA) are reported as important regulators of gene expression and represent an innovative pharmacological application as molecular biomarkers in cancer. The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC. We summarize the emerging roles of long non-coding RNAs in HNC and LC development and their possible use in early diagnosis.

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“…In Poland in 2015, 2536 new cases and 1610 deaths caused by laryngeal cancer were reported [1]. The most common location of this cancer is the glottis [2]. Thus, hoarseness—as a cancer-related symptom—facilitates diagnosis at early stages [3], leading to good treatment results [4–10].…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors in patients with T1 glottic cancer treated with radiotherapy

et al. 2019

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Purpose Presentation of long-term results of radiation treatment in patients with T1 glottic cancer and evaluation of prognostic factors. Methods We performed a retrospective analysis in a group of 569 patients with T1 squamous cell glottic carcinoma treated with radiotherapy at the Center of Oncology in Cracow between 1977 and 2007. In all, 503 (88%) patients presented with T1a stage disease and 66 (12%) with T1b. Anterior commissure infiltration was present in 179 (31%) patients. Average hemoglobin level prior to therapy was 13.9 g/dl. Using the body mass index (BMI), 114 (20%) patients were underweight, and 91 (16%) were overweight. Median time between collecting tumor specimen and beginning of radiotherapy was 56 days (range 14–145 days). Treatment regimen was normofractionated with single fraction ≤2 Gy in 102 (18%) and hypofractionated in 467 (82%) patients. Results The 5‑ and 10-year overall survival (OS), disease-specific survival (DSS) and local control (LC) rates were 85 and 68%, 88 and 86%, 89 and 87%, respectively. Multivariate analysis showed that tobacco smoking, low hemoglobin level (<13 g/dl), anterior commissure infiltration, fraction dose ≤2 Gy and time from collecting specimen to beginning of therapy longer than 30 days had negative impact on LC and DSS. Patients’ age over 60 years, worse performance status and malnutrition (BMI <18.5) had negative impacts on OS. Conclusions Radiotherapy is a highly effective treatment method in patients with T1N0M0 glottic cancer. LC and DSS may be improved following hypofractionation, smoking cessation, and shortening of waiting-time until start of treatment. OS was mainly influenced by nutritional and performance status.

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Head and neck: Laryngeal tumors: an overview

Abstract: This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.

Cited by 17 publications

References 15 publications

T1–2 glottic cancer treated with radiotherapy and/or surgery

T1–2 glottic cancer treated with radiotherapy and/or surgery

Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours

Prognostic factors in patients with T1 glottic cancer treated with radiotherapy

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