T1–2 glottic cancer treated with radiotherapy and/or surgery

Shelan, Mohamed; Anschuetz, Lukas; Schubert, Adrian D.; Bojaxhiu, Beat; Pra, Alan Dal; Behrensmeier, Frank; Aebersold, Daniel M.; Giger, Roland; Eliçin, Olgun

doi:10.1007/s00066-017-1139-4

Cited by 23 publications

(28 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the latest NCCN guidelines, surgery or definitive radiotherapy can be used for curing T1‐2N0M0 LSCC. Several studies have demonstrated improved survival with radiation over surgery . Survival benefit in patients with early‐stage LSCC undergoing surgery has also been reported in a number of other studies .…”

Section: Introductionmentioning

confidence: 74%

“…Briefly, patients with labeled primary sites C32.0-Glottis, C32.1-Supraglottis, C32.2-Subglottis, C32.3-Laryngeal cartilage, C32.8-Overlapping lesion of larynx, or C32.9-Larynx NOS were included. Exclusion criteria were as follows: (1) not SCC; (2) without positive histology confirmation; (3) not the first tumor; (4) not stage I or stage II; (4) chemotherapy received; (5) underwent both radiotherapy and surgery; (6) not beam radiation if radiotherapy administered. Conversion from the old version to the seventh AJCC TNM staging system was performed manually.…”

Section: Data Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

et al. 2018

View full text Add to dashboard Cite

There are conflicting reports about whether radiotherapy or surgery is optimal for early‐stage laryngeal squamous cell carcinoma (LSCC), although both have recently been recommended. Patients with T1‐2N0M0 LSCC in the population‐based SEER database who underwent radiotherapy or surgery were reviewed. Propensity score matching was used to eliminate the baseline variations. After matching, 1913 pairs of patients were included. Overall, patients who received radiotherapy had worse cancer‐specific survival than patients with surgery. After stratification, the survival in patients who received radiotherapy was worse with respect to the following characteristics: ≤60 years of age; T1a glottis cancer; well‐differentiated tumors; and with married status. In other patients, survival outcomes were similar in patients who received radiotherapy and underwent surgery. Our results indicate that radiotherapy is not preferable in early‐stage LSCC patients who are ≤60 years of age, have T1a glottis cancer or well‐differentiated tumors, or are married. In other patients, both radiotherapy and surgery are comparable. However, our results cannot be a reference before controlled, prospective trials are performed.

show abstract

Section: Introductionmentioning

confidence: 74%

Section: Data Selectionmentioning

confidence: 99%

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Today, a vast amount of clinical experience from single‐institution trials as well as prospective clinical trials on primary organ preserving treatment is available . Multimodality organ‐preservation treatment has become the treatment of choice for many tumor entities .…”

Section: Introductionmentioning

confidence: 99%

Long-Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High-Risk Bladder Cancer (Ta, Tis, T1, T2)

et al. 2019

View full text Add to dashboard Cite

Background. The aim of this study was to evaluate the efficacy and safety of chemoradiotherapy (RCT) combined with regional deep hyperthermia (RHT) of high-risk bladder cancer after transurethral resection of bladder tumor (TUR-BT). Materials and methods. Between 1982 and 2016, 369 patients with pTa, pTis, pT1, and pT2 cN0-1 cM0 bladder cancer were treated with a multimodal treatment after TUR-BT. All patients received radiotherapy (RT) of the bladder and regional lymph nodes. RCT was administered to 215 patients, RCT + RHT was administered to 79 patients, and RT was used in 75 patients. Treatment response was evaluated 4-6 weeks after treatment with TUR-BT. Results. Complete response (CR) overall was 83% (290/351), and in treatment groups was RT 68% (45/66), RCT 86% (178/208), and RCT + RHT 87% (67/77). CR was significantly improved by concurrent RCT compared with RT (odds ratio [OR], 2.32; 95% confidence interval [CI], 1.05-5.12; p = .037), less influenced by hyperthermia (OR, 2.56; 95% CI, 0.88-8.00; p = .092). Overall survival (OS) after RCT was superior to RT (hazard ratio [HR], 0.7; 95% CI, 0.50-0.99; p = .045). Five-year OS from unadjusted Kaplan-Meier estimates was RCT 64% versus RT 45%. Additional RHT increased 5-year OS to 87% (HR, 0.32; 95% CI, 0.18-0.58; p = .0001). RCT + RHT compared with RCT showed a significantly better bladder-preservation rate (HR, 0.13; 95% CI, 0.03-0.56; p = .006). Median follow-up was 71 months. The median number of RHT sessions was five. Conclusion. The multimodal treatment consisted of a maximal TUR-BT followed by RT; concomitant platinum-based chemotherapy combined with RHT in patients with high-grade bladder cancer improves local control, bladder-preservation rate, and OS. It offers a promising alternative to surgical therapies like radical cystectomy. The Oncologist 2019;24:e1341-e1350 Implications for Practice: Radical cystectomy with appropriate lymph node dissection has long represented the standard of care for muscle-invasive bladder cancer in medically fit patients, despite many centers reporting excellent long-term results for bladder preserving strategies. This retrospective analysis compares different therapeutic modalities in bladder-preservation therapy. The results of this study show that multimodal treatment consisting of maximal transurethral resection of bladder tumor followed by radiotherapy, concomitant platinum-based chemotherapy combined with regional deep hyperthermia in patients with Ta, Tis, T1-2 bladder carcinomas improves local control, bladder-preservation rate, and survival. More importantly, these findings offer a promising alternative to surgical therapies like radical cystectomy. The authors hope that, in the future, closer collaboration between urologists and radiotherapists will further improve treatments and therapies for the benefit of patients.Cumulative estimated DFS for RCT (40%; 95% CI, 34%-47% and 24%; 95% CI, 18%-30%) was superior to RT (20%; 95% Merten, Ott, Haderlein et al. e1345Abbreviations: CI, confidence interval; cis, associate...

show abstract

“…A recent analysis revealed an overall incidence of tracheostomies in patients with advanced laryngeal and hypopharyngeal cancer undergoing chemoradiotherapy (CRT) of 34% . The CRT protocols for laryngeal cancer allow the preservation of the organ with good locoregional disease control . Despite this organ preservation strategy, a high number of patients with head and neck cancer remain dependent on a feeding tube and tracheostomy .…”

Section: Introductionmentioning

confidence: 99%

“…2 The CRT protocols for laryngeal cancer allow the preservation of the organ with good locoregional disease control. 3,4 Despite this organ preservation strategy, a high number of patients with head and neck cancer remain dependent on a feeding tube and tracheostomy. 5 Radiotherapy (RT) causes fibrosis and edema, which may lead to an impaired laryngeal mobility and airway obstruction, requiring a life-saving tracheostomy.…”

Section: Introductionmentioning

confidence: 99%

Risk analysis for tracheostomy dependency in curatively treated laryngeal cancer with organ preservation

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background A tracheostomy has an enormous negative impact on the patient's quality of life. The purpose of this study is to describe risk factors for permanent tracheostomies in patients undergoing curative organ‐preserving treatment of laryngeal cancer. Methods The charts of all patients with laryngeal cancer diagnosed at our tertiary referral center were reviewed. Cases receiving a tracheostomy before, during, or after primary organ‐preserving treatment were eligible. Results A total of 87 patients who underwent tracheostomies were enrolled in the present study. During follow‐up, 48 patients (55%) required a permanent tracheostomy, whereas 39 patients (45%) were decannulated. Multivariate analysis revealed primary radiotherapy (RT; odds ratio [OR] 12.857; P < .001) and recurrence (OR 25.84; P < .001) as independent factors of permanent tracheostomy. Conclusion This study identifies primary curative RT and tumor relapse as independent risk factors of permanent tracheostomy dependency in patients with laryngeal cancer undergoing a tracheostomy during or after primary curative organ‐preserving treatment.

show abstract

T1–2 glottic cancer treated with radiotherapy and/or surgery

Abstract: Despite a possible selection bias, our series demonstrates improved RFS with RT over surgery in stage I glottic SCC.

Cited by 23 publications

References 46 publications

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

Radiotherapy vs surgery for T1‐2N0M0 laryngeal squamous cell carcinoma: A population‐based and propensity score matching study

Long-Term Experience of Chemoradiotherapy Combined with Deep Regional Hyperthermia for Organ Preservation in High-Risk Bladder Cancer (Ta, Tis, T1, T2)

Risk analysis for tracheostomy dependency in curatively treated laryngeal cancer with organ preservation

Contact Info

Product

Resources

About