Head and neck cancer treatment and physical plasma

Metelmann, H.‐R.; Nedrelow, David S.; Seebauer, Christian; Schuster, Matthias; Woedtke, Thomas von; Weltmann, K.‐D.; Kindler, Stefan; Metelmann, Philine H.; Finkelstein, Steven E.; Hoff, Daniel D. Von; Podmelle, Fred

doi:10.1016/j.cpme.2015.02.001

Cited by 196 publications

(166 citation statements)

References 35 publications

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“…Plasma can affect cells both directly and indirectly. Direct treatment of cancer using plasma is an important approach, and the first clinical application of plasma for cancer treatment has recently been reported61. Indirect treatment of cancer using plasma via solutions has been recently recognized as an important new chemotherapy41424362.…”

Section: Discussionmentioning

confidence: 99%

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Tanaka

Nakamura

Mizuno

et al. 2016

Sci Rep

181

166

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Non-thermal atmospheric pressure plasma is a novel approach for wound healing, blood coagulation, and cancer therapy. A recent discovery in the field of plasma medicine is that non-thermal atmospheric pressure plasma not only directly but also indirectly affects cells via plasma-treated liquids. This discovery has led to the use of non-thermal atmospheric pressure plasma as a novel chemotherapy. We refer to these plasma-treated liquids as plasma-activated liquids. We chose Ringer’s solutions to produce plasma-activated liquids for clinical applications. In vitro and in vivo experiments demonstrated that plasma-activated Ringer’s lactate solution has anti-tumor effects, but of the four components in Ringer’s lactate solution, only lactate exhibited anti-tumor effects through activation by non-thermal plasma. Nuclear magnetic resonance analyses indicate that plasma irradiation generates acetyl and pyruvic acid-like groups in Ringer’s lactate solution. Overall, these results suggest that plasma-activated Ringer’s lactate solution is promising for chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Tanaka

Nakamura

Mizuno

et al. 2016

Sci Rep

181

166

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“…Many other studies have focused on both modeling and diagnostics for a suite of laboratory devices. Perhaps most important, limited clinical tests have begun on humans and palliative treatment of cancer patients with contaminated ulcera, although more work needs to be done on animal models before large scale trials can commence [86].…”

Section: Advances In Science and Technology To Meet Challengesmentioning

confidence: 99%

The 2017 Plasma Roadmap: Low temperature plasma science and technology

Adamovich

Baalrud

Bogaerts

et al. 2017

J. Phys. D: Appl. Phys.

792

549

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“…The licensed cold plasma device known as kINPen MED (neoplas tools GmbH, Greifswald, Germany) was already used in palliative treatment of head and neck tumors [26] and the present temperature model might further help risk assessment of plasma devices for tumor treatment. The relationships among the skin-layer temperature, the plasma temperature, TTD and inlet velocity are shown in Figure 9.…”

Section: Computed Resultsmentioning

confidence: 99%

“…The system setup is shown in Figure 1, and the modeled zone that consists of discharge tube, air and skin is marked on the schematic diagram. wounds and infective skin diseases included (1) kINPen MED (neoplas tools GmbH, Greifswald, Germany) [25,26]; (2) MicroPlaSter plasma torch system developed and built by the Max Planck Institute for Extraterrestrial Physics in Garching/Germany and the company ADTEC Plasma Technology Co. Ltd., Hiroshima, Japan/London, UK [27] and (3) PlasmaDerm VU-2010 device (CINOGY GmbH, Duderstadt, Germany) [28]. Our developed model could help to assess potential risks of thermal damages to the skin that might be tedious to study experimentally.…”

Section: Methodsmentioning

confidence: 99%

Safeguarding against Inactivation Temperatures during Plasma Treatment of Skin: Multiphysics Model and Phase Field Method

Beni

2017

MCA

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Abstract:One of the most appealing applications of cold plasmas is medical treatment of the skin. An important concern is the capability to safeguard the non-targeted cells against inactivation temperatures during the plasma treatment. Unfortunately, it is problematic to experimentally determine the highest transient temperatures in these cells during the plasma treatment. In the present work, a complete multiphysics model was built based on finite element analysis using phase field method coupled with heat transfer and fluid dynamics to study the discharge phenomenon of cold plasma with helium carrier gas ejected out of a tube for skin treatment. In such plasmas with carrier gas, the fractions of plasma constituents are small compared to the carrier gas, so thermofluid analysis is needed for the carrier gas as the major contributor to the fluid and heat flow. The phase field method has been used to capture the moving helium gas in air, which has enabled us to compute fluid dynamics parameters for each phase individually. In addition to computational fluid dynamic analyses, we have also considered heat transfer in the fluids and to the skin using the Fourier law of heat conduction, which led to a multiphysics system. In the present paper, various flow velocities and tube-to-target distances (TTDs) have been considered to reveal the dependence of the fluid discharge output parameters on the flow and efficiency of heat transfer to the skin and the surrounding environment. The built model is a useful tool for future development of plasma treatment devices and to safeguard the non-targeted cells against inactivation temperatures.

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Head and neck cancer treatment and physical plasma

Cited by 196 publications

References 35 publications

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

The 2017 Plasma Roadmap: Low temperature plasma science and technology

Safeguarding against Inactivation Temperatures during Plasma Treatment of Skin: Multiphysics Model and Phase Field Method

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