Head and neck cancer

Rezende, Taia Maria Berto; Freire, Mirna de Souza; Franco, Octávio L.

doi:10.1002/cncr.25245

Cited by 57 publications

(26 citation statements)

References 78 publications

(81 reference statements)

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“…It is estimated that annually there are over 300000 oral cancer cases worldwide. 1 The oral squamous cell carcinoma (OSCC) accounts for over 90% of all oral cancers. According to the analysis of World Health Organization (WHO), OSCC has one of the leading mortality rates among all malignancies, with a 5-year mortality rate of approximately 50%.…”

Section: Introductionmentioning

confidence: 99%

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Zhang

Rong-mei

et al. 2015

ANAL. SCI.

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Silicon nanowire (SiNW) field-effect transistor (FET) biosensors have already been used as powerful sensors for the direct detection of disease-related biomarkers. However, the multiplexed detection of biomarkers in real samples is still challenging. Interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α) are two typical biomarkers of oral squamous cell carcinoma (OSCC). In this study, we developed a multiplexed detection methodology for IL-8 and TNF-α detection in saliva using SiNW FET biosensors. We fabricated the SiNW FET sensors using a top-down lithography fabrication technique. Subsequently, we achieved the multiplexed detection of two biomarkers in saliva by specific recognition of the two biomarkers with their corresponding antibodies, which were modified on the SiNW. The established method was found to have a limit of detection as low as 10 fg/mL in 1×PBS as well as 100 fg/mL in artificial saliva. Because of its advantages, including label-free and multiplexed detection, non-invasive analysis, highly sensitive and specific determination, the proposed method is expected to be widely used for the early diagnosis of OSCC.

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Section: Introductionmentioning

confidence: 99%

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Zhang

Rong-mei

et al. 2015

ANAL. SCI.

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“…Almost all (95%) head and neck cancers are squamous cell carcinomas (HNSCC) [1]. HNSCC is the sixth most common type of cancer and cancer-related death that accounts for 6% of all cancer cases [2][3].…”

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confidence: 99%

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Xie¹,

Fan²,

Jiang³

et al. 2015

neo

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For decades, despite the advancement of medical science, the prognosis of head and neck squamous cell carcinoma (HNSCC), has not improved. Deltonin is one of the major active components of Dioscorea Zingiberensis Wright that has been used for anthrax, rheumatic heart disease, rheumatoid arthritis etc. By employing HNSCC FaDu cell and normal human epidermal keratinocyte, we investigate deltonin efficacy and associated mechanism in both cell culture and nude mice xenografts. Deltonin treatment selectively prevents proliferation of FaDu cells by cell-cycle arrest and induction of apoptosis, via activating checkpoint kinase Chk1and Chk2 as well as caspases 8, 9 and 3. Meanwhile, we found that treatment with deltonin induced autophagy, which played a protective role against deltonin-induced apoptosis. Further studies revealed that deltonin activated autophagy by Akt-mTOR signaling. Additionally, xenograft model showed that administration of deltonin significantly inhibited tumor growth and prolonged survival of tumor bearing mice. Our studies suggested that deltonin might be a potential chemotherapeutic agent against HNSCC, which might contribute to clinical application and pharmacological study of deltonin in future anti-cancer research.

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Section: Introductionmentioning

confidence: 99%

“…HNC is defined as epithelial malignancies that arise in the aerodigestive tract (paranasal sinuses, nasal and oral cavity, pharynx and larynx) and can metastasize to different locations (Rezende et al, 2010). About 75% of HNCs are oral cancers and 90% of oral cancers are diagnosed as oral squamous cell carcinomas (OSCC) (Rezende et al, 2010; National Cancer Institute, 2013). Despite therapeutic and technological advances, the prognosis for HNC has not improved in decades due to its malignant and recurrent properties (Forastiere et al, 2001; Mao et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…However, the current procedure is subjective and does not capture the full heterogeneic properties of neoplastic processes, as it is difficult to distinguish between precancerous from cancerous and malignant lesions (Rezende et al, 2010; Yu and Snyder, 2016). Early studies with magnetic resonance spectroscopy (MRS) using patient tissue samples demonstrated that a higher choline to creatine ratio was observed in HNC samples compared to healthy controls (Mukherji et al, 1997; El-Sayed et al, 2002; Table 1).…”

Section: Introductionmentioning

confidence: 99%

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Metabolomics of Head and Neck Cancer: A Mini-Review

et al. 2016

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Metabolomics is used in systems biology to enhance the understanding of complex disease processes, such as cancer. Head and neck cancer (HNC) is an epithelial malignancy that arises in the upper aerodigestive tract and affects more than half a million people worldwide each year. Recently, significant effort has focused on integrating multiple “omics” technologies for oncological research. In particular, research has been focused on identifying tumor-specific metabolite profiles using different sample types (biological fluids, cells and tissues) and a variety of metabolomic platforms and technologies. With our current understanding of molecular abnormalities of HNC, the addition of metabolomic studies will enhance our knowledge of the pathogenesis of this disease and potentially aid in the development of novel strategies to prevent and treat HNC. In this review, we summarize the proposed hypotheses and conclusions from publications that reported findings on the metabolomics of HNC. In addition, we address the potential influence of host-microbe metabolomics in cancer. From a systems biology perspective, the integrative use of genomics, transcriptomics and proteomics will be extremely important for future translational metabolomic-based research discoveries.

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Head and neck cancer

Cited by 57 publications

References 78 publications

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Silicon Nanowire Biosensor for Highly Sensitive and Multiplexed Detection of Oral Squamous Cell Carcinoma Biomarkers in Saliva

Deltonin induced both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell

Metabolomics of Head and Neck Cancer: A Mini-Review

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