HDLs, Diabetes, and Metabolic Syndrome

Vollenweider, Péter; Eckardstein, Arnold von; Widmann, Christian

doi:10.1007/978-3-319-09665-0_12

Cited by 49 publications

(31 citation statements)

References 89 publications

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“…MetS is a complex clustering of metabolic disorders with a combination of components, such as abdominal fat, high blood pressure, elevated triglyceride level, low high-density lipoprotein (HDL) cholesterol levels, and glucose intolerance [2]. Each MetS component is a known risk factor for increased blood vessel occlusion, incidence and mortality of cardiovascular disease, type 2 diabetes mellitus, and stroke [3–7].…”

Section: Introductionmentioning

confidence: 99%

Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults

et al. 2017

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BackgroundThe relationship between alcohol consumption and metabolic syndrome (MetS) remains controversial. This study investigated the relationship between alcohol consumption and MetS components and prevalence.Material/MethodsWe analyzed 10 037 subjects (3076 MetS and 6961 non-MetS) in a community-based cohort.MetS was defined according to the ATP III Guidelines. Subjects were divided according to amount of alcohol consumption; non-drinker, very light (0.1–5.0 g/day), light (5.1–15.0 g/day), moderate (15.1–30.0 g/day), and heavy drinker (>30 g/day). Multiple logistic regression models were performed to estimate odds ratios (ORs) and confidence intervals (CIs). The analyses were performed in men and women separately. SPSS statistical software was used for analyses.ResultsThe prevalence of MetS in both males and females was associated with alcohol drinking status (p<0.0001). Amount of alcohol consumption (0.1–5.0 g/day) was significantly associated with lower prevalence of MetS in both genders compared to non-drinkers. Amount of alcohol consumption (>30.0 g/day) did not show a significant association with prevalence of MetS. However, alcohol consumption (>30.0 g/day) showed an association with glucose and HDL cholesterol among the components of MetS.ConclusionsOur results indicate that alcohol drinking (0.1–5.0 g/day) contributed to decrease prevalence of MetS and components, including triglyceride and HDL cholesterol.

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Section: Introductionmentioning

confidence: 99%

Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults

et al. 2017

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“…19 These conditions indicate the presence of vitrosus circulation where low HDL cholesterol levels due to diabetic foot ulcers will lead to progressive deterioration of diabetic foot ulcers. 19,20 …”

Section: Discussionmentioning

confidence: 99%

Correlation of HDL cholesterol serum and Wagner’s severity level of diabetic foot ulcers

Kartono¹,

Mallapasi²,

Mulawardi³

et al. 2017

Int J Res Med Sci

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Background: Diabetic foot ulcers are one of the leading causes of amputation in non-traumatic patients. This research aimed to investigate the correlation between the level of HDL cholesterol and the severity level of diabetic foot ulcer based on Wagner classification. The study conducted at Wahidin Sudirohusodo Hospital, Makassar, Indonesia.Methods: This is an observational study with the cross-sectional design. The data collected before and after the treatment. The change of the levels of HDL cholesterol and the severity level of the diabetic foot ulcer based on Wagner classification during the treatment were analyzed. Data analyzed using Spearman Correlation test, the paired t-test to assess the change in the levels of HDL cholesterol and the levels of severity of diabetic foot ulcer based on Wagner classification at the time admission and after the treatment. ANOVA test was used to observe the reduction significance of the severity of diabetic foot ulcer based on Wagner classification, and it was categorized as significant if p<0.05.Results: The results indicated that there is a correlation between the level of HDL cholesterol and the severity level of diabetic foot ulcer based on Wagner classification either at the early treatment with p-value = 0.003 (r = - 0.448) and the end of the treatment with p-value = 0.001(r = - 0.477). The lower of the level of cholesterol HDL, the higher was the severity level of the diabetic foot ulcer. Meanwhile, the correlation between the increase of the level of HDL cholesterol and the reduction of Wagner classification during the treatment was statistically insignificant with p-value = 0.100 (r = - 0.215).Conclusions: there was a correlation between elevated HDL cholesterol levels during treatment with Wagner classification decrease during treatment, the higher the HDL change, the higher the Wagner classification, but this was weak correlation and statistically insignificant.

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“…HDLs may also exert anti-diabetogenic functions on the beta cells of the endocrine pancreas, notably by potently inhibiting stress-induced cell death and enhancing glucose-stimulated insulin secretion. HDLs have also been found to stimulate insulindependent glucose uptake into skeletal muscle, adipose tissue and liver 6 .…”

Section: Hdl-cholesterolin Dmmentioning

confidence: 99%

“…13 . Both increased LDL and decreased HDL -Cholesterols may play in the precipitation of uncontrolled DM 6,14,16 . Our study has predicted increase in the levels of TG/HDL ratio for all patients as well as males &females, but when calculated AIP was used for correlation it did not show any significance association for HbA1c and FPG between Controls and Patients, but a highly significance correlation was observed when only the ratio was used.…”

Section: Exclusion Criteriamentioning

confidence: 99%

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2016

IJPSR

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HDLs, Diabetes, and Metabolic Syndrome

Cited by 49 publications

References 89 publications

Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults

Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults

Correlation of HDL cholesterol serum and Wagner’s severity level of diabetic foot ulcers

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