HDL cholesterol efflux capacity and phospholipid content are associated with the severity of acute ischemic stroke and predict its outcome

Papagiannis, Achilleas; Gkolfinopoulou, Christina; Τζιόμαλος, Κωνσταντίνος; Dedemadi, Anastasia-Georgia; Polychronopoulos, Georgios; Milonas, Dimitrios; Savopoulos, Christos; Hatzitolios, Apostolos; Chroni, Angeliki

doi:10.1016/j.cca.2023.117229

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…This enzyme esterifies cholesterol in HDL and hydrolyzes the acyl group at the sn-2 position of HDL phospholipids. Therefore, it is associated with HDL atheroprotective functions, including cholesterol efflux capacity, and its downregulation is linked with the severity and outcome of acute ischemic stroke [45]. GPX3 is an antioxidant enzyme, associated with HDL particles, that scavenges reactive oxygen species in the extracellular compartment.…”

Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study

Naranjo,

Álvarez-Soria,

Aranda-Villalobos

et al. 2024

IJMS

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Hydroxytyrosol (HT) is a bioactive olive oil phenol with beneficial effects in a number of pathological situations. We have previously demonstrated that an HT-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic-stroke-associated damage in mice. Our exploratory pilot study examined this effect in humans. Particularly, a nutritional supplement containing 15 mg of HT/day was administered to patients 24 h after the onset of stroke, for 45 days. Biochemical and oxidative-stress-related parameters, blood pressure levels, serum proteome, and neurological and functional outcomes were evaluated at 45 and 90 days and compared to a control group. The main findings were that the daily administration of HT after stroke could: (i) favor the decrease in the percentage of glycated hemoglobin and diastolic blood pressure, (ii) control the increase in nitric oxide and exert a plausible protective effect in oxidative stress, (iii) modulate the evolution of the serum proteome and, particularly, the expression of apolipoproteins, and (iv) be beneficial for certain neurological and functional outcomes. Although a larger trial is necessary, this study suggests that HT could be a beneficial nutritional complement in the management of human stroke.

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Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study

Naranjo,

Álvarez-Soria,

Aranda-Villalobos

et al. 2024

IJMS

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“…11 Currently, there are still a few studies related to HDL cholesterol levels in acute thrombotic stroke patients with the functional degree of the NIHSS, in which theoretically there is a correlation between HDL cholesterol levels as a predictor of the formation of atherosclerosis of blood vessels in acute thrombotic stroke, which can affect the functional degree in thrombotic stroke sufferers. 13…”

Section: Introductionmentioning

confidence: 99%

HDL Cholesterol and Functional Scale Measured by the NIHSS in Acute Thrombotic Stroke Patients

Sari

Hidayati

Nugraha

2023

AKSONA

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Highlight: Stroke is one of the leading causes of death and disability in the world. There is correlation between HDL cholesterol in acute thrombotic patients and the functional degree of the NIHSS. The lower rate of HDL cholesterol is related to the higher NIHSS score or the higher level of stroke severity. ABSTRACT Introduction: Stroke is one of the world’s leading causes of death and disability. Acute thrombotic stroke accounts for 87% of all stroke cases. The study of the correlation between high-density lipoprotein (HDL) cholesterol levels and acute thrombotic stroke is still limited, especially on the relationship between HDL levels and the degree of functional stroke. Objective: This study aimed to prove a correlation between HDL cholesterol and the functional scale measured by the NIHSS (National Institutes of Health Stroke Scale) in acute thrombotic stroke. Methods: The design study was cross-sectional, with sampling by consecutive admission based on inclusion and exclusion criteria in the neurological ward (Seruni A) at Dr.Soetomo General Academic Hospital, Surabaya. The NIHSS was used to determine the degree of functional scale, and HDL levels were measured by enzymatic endpoint methods. Results: From the 40 subjects studied, 16 (40%) had normal HDL levels of ≥ 40 mg/dL with an NIHSS score between 0–10, and 24 (60%) had lower HDL levels of ≤ 40 mg/dL with an NUHSS score between 0–20. There were significant results in this study (r = 0.391 and p = 0.013). Conclusion: There was a negative correlation between HDL cholesterol levels and the functional scale measured by the NIHSS in acute thrombotic stroke patients.

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HDL cholesterol efflux capacity and phospholipid content are associated with the severity of acute ischemic stroke and predict its outcome

Cited by 2 publications

References 42 publications

Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study

Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study

HDL Cholesterol and Functional Scale Measured by the NIHSS in Acute Thrombotic Stroke Patients

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