2024
DOI: 10.1111/cns.14573
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HDAC9‐mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease

Hai‐Long Zhang,
Shufen Hu,
Pin Yang
et al.

Abstract: AimsAlzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment. AD pathology involves protein acetylation. Previous studies have mainly focused on histone acetylation in AD, however, the roles of nonhistone acetylation in AD are less explored.MethodsThe protein acetylation and expression levels were detected by western blotting and co‐immunoprecipitation. The stoichiometry of acetylation was measured by home‐made and site‐specific antibodies… Show more

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