2024
DOI: 10.1101/2024.06.01.596932
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Dynamic regulation of mRNA acetylation at synapses by learning and memory

Hai-Qian Zhou,
Jia-Wei Zhang,
Zhen Zhu
et al.

Abstract: N4-acetylcytidine (ac4C) is the only RNA acetylation modification identified in eukaryotes and has recently been recognized as an epitranscriptomic mechanism regulating mRNA stability and translation efficiency. However, the function and regulation of mRNA acetylation in the brain remain largely unknown. In this study, the presence of ac4C in mRNA was demonstrated by dot blot analysis and UPLC-MS/MS. A transcriptome-wide mapping of ac4C was performed in the hippocampus of adult mice trained in the Morris water… Show more

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