HCV-RNA of the hepatocytes of the complete responders with disappearance serum HCV-RNA after IFN treatment. Using in situ hybridization.

We experienced a case of chronic hepatitis C showing spontaneous resolution. The patient was diagnosed as having chronic hepatitis with moderate activity, non‐A non‐B type, after laparoscopy with liver histology in 1982, and was followed up thereafter at our out‐patient clinic. His aspartate aminotransferase (AST)and alanine aminotransferase (ALT) levels fluctuated but had stabilized by 1990. A second laparoscopy with liver histology, conducted in 1993, revealed non‐specific reactive hepatitis. Serum hepatitis C virus RNA (HCV‐RNA) had been strongly positive in 1982 but was negative in 1990. Interferon therapy may not be indicated in such cases.

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Spontaneous Resolution of Chronic Hepatitis C – A Case Report

Sakai

Watanabe

Sato

et al. 1995

Digestive Endoscopy

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A case of chronic hepatitis C reactivation and hepatocellular carcinoma after achievement of HCV RNA negative treated by combination therapy of IFN and ribavirin

Yamada

Kobayashi

Okuse

et al. 2015

Acta hepatologica Japonica

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聡¹,

由人²,

豊³

et al. 2009

J Microwave Surg

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The underlying hepatopath may cause intra-hepatic recurrence even if curative resection for hepatocellular carcinoma (HCC) is achieved. Two patterns of intra-hepatic recurrence is exist, multicentric carcinogenesis with chronic hepatopath and intra-hepatic metastasis. We must diagnose the difference of these 2 characters after treatment, hepatectomy or ablation, for HCC and perform the post-operative adjuvant therapy expecting the 2 patterns. The prevention of multicentric carcinogenesis is postoperative interferon (IFN) therapy on hepatitis C virus-related HCC and the prevention of intrahepatic metastasis is postoperateive transcatheter arterial infusion chemotherapy (TAI) and cell immunotherapy on advanced HCC. The postoperative adjuvant therapy for HCC was found to be an effective adjuvant therapy that significantly improved survival and disease-free survival rates, and we have been not satisfied with the therapiatic effects. Although randomized controlled study with a greater number of patients is necessary.

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HCV-RNA of the hepatocytes of the complete responders with disappearance serum HCV-RNA after IFN treatment. Using in situ hybridization.

Abstract: Treatment of chronic non-A , non-B hepatitis with recombinant of human alpha interferon .

Cited by 3 publications

References 10 publications

Spontaneous Resolution of Chronic Hepatitis C – A Case Report

Spontaneous Resolution of Chronic Hepatitis C – A Case Report

A case of chronic hepatitis C reactivation and hepatocellular carcinoma after achievement of HCV RNA negative treated by combination therapy of IFN and ribavirin

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