HBsAg and anti-HCV screening in elderly hospitalized patients of a German tertiary referral centre

Kant, J.; Kratzsch, Juergen; Maier, Melanie; Liebert, Uwe G.; Berg, Thomas

doi:10.1055/s-0041-106656

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…The anti-HCV prevalence in the GP ranged from 0.2 to 1.9%, and was 1.5% among baby boomers (proxy population) ( 42 ). Two studies reported an HCV RNA prevalence of 0.2% ( 5 ) and 0.4%, respectively ( 44 ).…”

Section: Resultsmentioning

confidence: 99%

“…A higher prevalence is often found among males and with increasing age (5,61,62), and using baby boomers as proxy population for the GP in Germany should be carefully considered. The study which compared baby boomers and GP in this study found similar prevalence of HBsAg prevalence in the two groups, but higher anti-HCV prevalence among the German baby boomer population (42). Data from first time blood donors were included as this group is more likely to resemble the GP compared to multiple blood donors.…”

Section: Prevalence In General Populationmentioning

confidence: 90%

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Prevalence of Hepatitis B, C, and D in Germany: Results From a Scoping Review

Sperle

Steffen

Leendertz

et al. 2020

Front. Public Health

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Background: One of the five strategic directions in the World Health Organization global health sector strategy on viral hepatitis 2016-2021 is to generate strong strategic information for focused action to understand the viral hepatitis epidemic and focus the response. Knowledge of national prevalence is a cornerstone of strategic information. Germany is considered to be a low prevalence country for viral hepatitis B, C, and D, however the prevalence is likely to be higher among at-risk groups. Methods: The aim of this work was to give a detailed overview of the prevalence of viral hepatitis B (HBsAg, anti-HBc), C (anti-HCV, HCV RNA), and D (anti-HDV, HDV RNA) in different population groups in Germany. Therefore, we analyzed the results of a comprehensive literature search on various aspects of the epidemiological situation of hepatitis B, C, and D in Germany. Eligible publications including information on hepatitis B, C, and D prevalence were extracted from the overall spreadsheet table and summarized and analyzed based on virus and different population groups. A quality appraisal was performed using a checklist developed by Hoy et al. to assess risk of bias in prevalence studies. Results: Overall, 51 publications were identified through the literature search. The overall prevalence of HBsAg in the general (and proxy) population ranged from 0.3 to 1.6%. Among at-risk groups, including clinical populations and health care workers, the HBsAg prevalence ranged from 0.2% (among rheumatic patients) to 4.5% among HIV positive patients. The overall prevalence of anti-HCV in the general (and proxy) population ranged from 0.2 to 1.9%. Among at-risk groups, including clinical populations and health care workers, the anti-HCV prevalence ranged from 0.04% (among health care workers) to 68.0% among people who inject drugs. Conclusions: The hepatitis B and C prevalence in the general population in Germany is low. Prevalence is high to very high among at-risk populations, however for some Sperle et al. Hepatitis B, C, and D Prevalence groups evidence was incomplete or missing completely. To reach the elimination goals in Germany and implement a targeted response, more research among at-risk groups is needed.

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Section: Resultsmentioning

confidence: 99%

Section: Prevalence In General Populationmentioning

confidence: 90%

Prevalence of Hepatitis B, C, and D in Germany: Results From a Scoping Review

Sperle

Steffen

Leendertz

et al. 2020

Front. Public Health

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confidence: 99%

External quality assessment for dual detection of HBsAg and anti-HCV in serum

Thuan¹,

Uyen²,

Chuong³

et al. 2022

Pharm Sci Asia

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Hepatitis B surface Antigen (HBsAg) and hepatitis C antibody (anti-HCV) assays have been performed in most laboratories using a variety of analytical methods with different reagents for Hepatitis B virus (HBV) and Hepatitis C virus (HCV) screening [1][2] . The purpose of this study was to develop an EQA program for dual HBsAg and anti-HCV serological testing to ensure the accuracy and reliability of serological assays. A serum panel of 12 samples containing three negative, three positives for each virus and three positives for both of HBsAg and anti-HCV. These panels were distributed to 102 laboratories in the South of Vietnam. They were required to report their results and any problems encountered on EQA panel. The results show that performance of HBsAg and anti-HCV tests is not only different in terms of method used but also in the types of biological products. Rapid tests (RTs) to detect HBsAg and anti-HCV were most commonly used to screen for HBV and HCV in laboratories. The coincidence rates of RTs for HBsAg and anti-HCV serological assays were 88.24% and 89.86% respectively, while electrochemiluminescence (ECLs) and chemiluminescent immunoassays (CLIAs), Enzymelinked immunosorbent assay (ELISA) showed the best performance for both HBsAg and anti-HCV testing. The most challenging was failed to detect weak positive samples. In conclusion, the differences in test results within and between groups of HBsAg and anti-HCV assay methods indicated a need to improve test conditions at laboratories in Viet Nam.

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“…However, older patients are candidates for elevated risk for advanced liver disease. (12).…”

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confidence: 99%

Retrospective, single-center evaluation of liver cirrhosis cases in a geriatric population

2020

Deu Med J

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Since there is insufficient epidemiological data on liver cirrhosis, especially in the elderly population of many countries, we aimed to evaluate geriatric cases with liver cirrhosis hospitalized at our gastroenterology clinic, retrospectively. Materials and Methods:The study included 99 patients aged 65 years and over who were hospitalized with liver cirrhosis in Ege University Faculty of Medicine, department of gastroenterology. The socio-demographic, clinical and laboratory data were recorded from the patient files.Results: In total, 99 elderly patients (mean age 71.7 ± 5.2 years; 59% male) were included. Hepatocellular carcinoma was statistically significantly correlated with etiology, presence of ascites, the Model of End-Stage Liver Disease score and the Child-Turcotte-Pugh score (p=0.003, p=0.009, p=0.033, p=0.003, respectively). The presence of esophageal varices was statistically significantly correlated with class and scores of the Child-Turcotte-Pugh, total bilirubin, Model of End-Stage Liver Disease score and the presence of ascites (p< 0.0001, p=0.001, p=0.011, p=0.004, p=0.004, respectively). Conclusion:The main etiology of liver cirrhosis was Hepatitis C virus, which accounted for almost one-third of the cirrhotic elderly inpatients at the gastroenterology department. Hepatocellular carsinoma was the leading cause of hospitalization. Elderly patients with liver cirrhosis should be carefully evaluated for cirrhosis complications. The Child-Turcotte-Pugh classification and Model of End-Stage Liver Disease scoring should be undertaken, and the suitability for liver transplantation should be considered in the follow-up and treatment of this patients.

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HBsAg and anti-HCV screening in elderly hospitalized patients of a German tertiary referral centre

Abstract: HBsAg and anti-HCV were underdiagnosed in a senescent population, however, only few cases presented with advanced liver disease. Referrals from nursing homes were at increased risk for HBV infection.

Cited by 7 publications

References 13 publications

Prevalence of Hepatitis B, C, and D in Germany: Results From a Scoping Review

Prevalence of Hepatitis B, C, and D in Germany: Results From a Scoping Review

External quality assessment for dual detection of HBsAg and anti-HCV in serum

Retrospective, single-center evaluation of liver cirrhosis cases in a geriatric population

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