HbA1c Measurement Improves the Detection of Type 2 Diabetes in High-Risk Individuals With Nondiagnostic Levels of Fasting Plasma Glucose

Perry, Rachel; Shankar, R. Ravi; Fineberg, Naomi S.; McGill, Janet B.; Baron, Alain

doi:10.2337/diacare.24.3.465

Cited by 142 publications

(104 citation statements)

References 46 publications

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“…This is close to the 15% prevalence recently reported from the Tayside Diabetes Network 232 and the 17% based on the Early Diabetes Intervention Program (EDIP) study. 211 Analyses from NHANES III and other studies show a marked change in prevalence above an HbA 1c of 5.9%, 17 confirming that our assumption above is reasonable.…”

Section: Microvascular Complicationssupporting

confidence: 71%

Screening for type 2 diabetes: literature review and economic modelling

Waugh¹,

Scotland²,

McNamee³

et al. 2007

Health Technol Assess

243

194

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Section: Microvascular Complicationssupporting

confidence: 71%

Screening for type 2 diabetes: literature review and economic modelling

Waugh¹,

Scotland²,

McNamee³

et al. 2007

Health Technol Assess

243

194

View full text Add to dashboard Cite

show abstract

“…HbA1c measurement improves the sensitivity of screening in high-risk individuals. 14 The results of our study showed that the level of HbA 1c is significantly higher with declining degrees of potency. Our results showed that in patients with good potency, the mean level of HbA 1c was 7.9%; in patients with fair potency, the mean level of HbA 1c was 8.2%, whereas in patients with poor potency the mean level of HbA 1c was 11%.…”

Section: Discussionmentioning

confidence: 50%

Erectile function in men with diabetes type 2: correlation with glycemic control

et al. 2009

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Men with diabetes have an increased risk for erectile dysfunction (ED) than those without diabetes. The diabetes control and complications trial clearly showed that better long-term control of blood glucose in diabetes type 1 is associated with decreased frequency and delayed the onset of microvascular complications. The aim of this study is to explore the role of glycemic control, and its correlation to sexual function in patients with diabetes type 2. One hundred patients were selected for the study according to the following criteria: all the cases were presenting with diabetes type 2 as a single risk factor for ED, age being between 35 and 50 years and free of liver and kidney failure, and blood dyscrasis. The selected patients were evaluated for sexual function by asking the patients to complete the abridged form of the International Index of Erectile Function (IIEF). The evaluation of glycemic control was based on the measurement of hemoglobin A 1c (HbA 1c ) values. Our results showed that the level of HbA 1c is significantly higher with declining degrees of potency (P-value ¼ 0.003). Also, there is an association between potency degree and glycemic control (P ¼ 0.002). We conclude that glycemic control is independently and inversely associated with ED in men with diabetes type 2.

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“…Some of the men without a DM-FPG but with a high 2hPG could be screened because they have high HbA 1c . A recent article shows that for the 101 subjects with a DM-2hPG, 45% have a DM-FPG whereas 62% have an HbA 1c above 6.1% (mean ± 2SD), enabling the detection of additional subjects with a DM-2hPG [15]. As commented by the American Diabetes Association Expert Committee [6], the FPG is strongly recommended in clinical settings because it is easier to carry out than an OGTT and less expensive.…”

Section: Discussionmentioning

confidence: 99%

Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study

2002

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Aims/hypothesis. We examined whether the 2-h plasma glucose (2hPG) concentration after a 75 g OGTT is predictive of death in men with a diabetic, an impaired or a normal fasting plasma glucose concentration (DM-FPG: ≥7.0 mmol/l; IFG: 6.1-6.9 mmol/l; normal-FPG: <6.1 mmol/l). Methods. The 17-year mortality of 7018 men, aged 44 to 55 years, from the Paris Prospective Study, who were not known to be diabetic at baseline was studied. Results. The 2hPG was not associated with early mortality in men with a DM-FPG in contrast to men with an IFG or a normal-FPG; for an increase from 10 to 11 mmol/l in the 2hPG, the age-adjusted hazards ratios were 1.01 (95% CI 0.95-1.08), 1.15 (1.03-1.28) and 1.24 (1.18-1.31) respectively. Coronary heart disease mortality and within this category sudden death but not ischaemic heart disease death, were related with 2hPG but only in the men with normal FPG. However, the prediction by 2hPG did not differ between the men with DM-FPG, an IFG or a normal-FPG: the overall age-adjusted hazards ratios for these three causes of death were 1.09 (1.00-1.18), 1.13 (1.02-1.26) and 1.13 (0.99-1.29), respectively. Conclusion/interpretation. 2hPG is unequivocally prognostic for all-cause mortality only in men with normal FPG. Screening men with an IFG by using a 75 g OGTT is of limited benefit. [Diabetologia (2002[Diabetologia ( ) 45:1224[Diabetologia ( -1230

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HbA1c Measurement Improves the Detection of Type 2 Diabetes in High-Risk Individuals With Nondiagnostic Levels of Fasting Plasma Glucose

Cited by 142 publications

References 46 publications

Screening for type 2 diabetes: literature review and economic modelling

Screening for type 2 diabetes: literature review and economic modelling

Erectile function in men with diabetes type 2: correlation with glycemic control

Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study

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