Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study

Abstract

Aims/hypothesis. We examined whether the 2-h plasma glucose (2hPG) concentration after a 75 g OGTT is predictive of death in men with a diabetic, an impaired or a normal fasting plasma glucose concentration (DM-FPG: ≥7.0 mmol/l; IFG: 6.1-6.9 mmol/l; normal-FPG: <6.1 mmol/l). Methods. The 17-year mortality of 7018 men, aged 44 to 55 years, from the Paris Prospective Study, who were not known to be diabetic at baseline was studied. Results. The 2hPG was not associated with early mortality in men with a DM-FPG in contrast to men with an IFG or a normal-FPG; for an increase from 10 to 11 mmol/l in the 2hPG, the age-adjusted hazards ratios were 1.01 (95% CI 0.95-1.08), 1.15 (1.03-1.28) and 1.24 (1.18-1.31) respectively. Coronary heart disease mortality and within this category sudden death but not ischaemic heart disease death, were related with 2hPG but only in the men with normal FPG. However, the prediction by 2hPG did not differ between the men with DM-FPG, an IFG or a normal-FPG: the overall age-adjusted hazards ratios for these three causes of death were 1.09 (1.00-1.18), 1.13 (1.02-1.26) and 1.13 (0.99-1.29), respectively. Conclusion/interpretation. 2hPG is unequivocally prognostic for all-cause mortality only in men with normal FPG. Screening men with an IFG by using a 75 g OGTT is of limited benefit. [Diabetologia (2002[Diabetologia ( ) 45:1224[Diabetologia ( -1230

Prediabetes and the risk of cancer: a meta-analysis

“…After screening the abstracts, 67 qualified for a full review. Finally, 16 prospective cohort studies [8][9][10][11][12][13][14][15][16][17][18][24][25][26][27][28] comprising 891,426 individuals satisfied the study inclusion criteria and were analysed ( Fig. 1).…”

“…Asians accounted for 57.3% of all participants in the 16 studies. Three studies only enrolled men [12,24,25], two studies only enrolled women [9,26], and the other studies included both men and women. The duration of follow-up ranged from 3.6 to 37 years.…”

“…All the included studies excluded individuals with an FPG ≥7.1 mmol/l. Seven studies only measured FPG at baseline without performing OGTTs; therefore, these studies possibly enrolled patients with a 2 h plasma glucose ≥11.1 mmol/l [9,10,12,14,15,25,26].…”

Glicemia pós-prandial

“…Recentemente, foram publicados outros resultados do Paris Prospective Study, envolvendo policiais submetidos a TOTG no início do seguimento há 17 anos (22). De acordo com a categoria de tolerância à glicose, a mortalidade destes indivíduos foi sendo reportada.…”

Cinética plasmática do colesterol livre e do colesterol esterificado e transferência in vitro de lípides para a HDL, utilizando uma nanoemulsão lipídica artificial, em indivíduos com intolerância à glicose

“…Assim como no diabetes clínico, o indivíduo com IG, apesar de caracterizar uma fase mais precoce da história natural da doença, também está igualmente susceptível a desenvolver um evento cardiovascular (COUTINHO et al, 1999;TOMINAGA et al, 1999;DECODE, 2001;BALKAU et al, 2002;MEIGS et al, 2002;STERN et al, 2002;LEVITAN et al, 2004;NATHAN et al, 2007 Outros estudos mostram que independente da glicose de jejum, a hiperglicemia pós-prandial representa alto risco para a DCV (BONORA e MUGGEO, 2001;DECODE, 2001;ISOMAA, et al, 2001;GERICH, 2003).…”