HbA1c is a risk factor for cardiovascular disease in association with oxidative stress in patients with type 2 diabetes mellitus

Palem, Siva Prasad

doi:10.18203/2320-6012.ijrms20172998

Cited by 3 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is because of the effect of the process of glycation. Since HbA1c is a compound synthesized from the nonenzymatic glycation reaction of glucose and hemoglobin, especially in poorly con-trolled diabetes [52], an increase in HbA1c is associated with increased glycation, nonenzymatic addition of glucose to amino groups of proteins, due to hyperglycemia. Glycation enhances the covalent binding of lipoproteins to vascular wall proteins, promoting sequestration, free radical release, and hence inducing inflammation which all lead to the development of atherosclerosis and PAD.…”

Section: Journal Of Diabetes Researchmentioning

confidence: 99%

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Akalu

Birhan

2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Background. Peripheral arterial disease (PAD), one of the major macrovascular complications of diabetes, is associated with cardiovascular mortality and a high rate of disability following the amputation of an extremity in diabetes patients. However, there is no data on the prevalence of PAD among type 2 diabetes patients in Ethiopia. Therefore, the current study is aimed at determining the prevalence and associated factors of PAD among type 2 diabetes patients at Debre Tabor General Hospital, Debre Tabor, Northwest Ethiopia. Methods. An institution-based cross-sectional study was conducted among type 2 diabetes mellitus patients from February 1 to August 30, 2019. A pretested interviewer-administered questionnaire was used to collect the data. The presence of stenosis and its grading were determined by color Doppler ultrasonography. Data were entered using EpiData-V.4.6 and analyzed by STATA-14. Bivariable and multivariable logistic regression was performed to identify associated factors of peripheral arterial disease. Adjusted odds ratio (AOR) and its confidence interval were estimated for potential predictors included in the final model. P≤0.05 was used to declare statistical significance. Results. The mean age of the study participants was 61.2±7.3 years. One hundred seventy-two (61.4%) patients were males. The prevalence of PAD in this study was 30.7% (95% CI (25.3-36.2%)). Of these, 37 (43%) were symptomatic. Age (AOR=1.09, 95% CI (1.03-1.16)), higher HbA1c (AOR=1.97, 95% CI (1.03-3.40)), being an ex-smoker (AOR=4.68, 95% CI (1.93-11.30)), and current cigarette smoking (AOR=5.84, 95% CI (1.79-19.04)) were significantly associated with PAD. Conclusion. The prevalence of peripheral arterial disease among type 2 diabetes patients was high. Increasing age, high HbA1c, and being cigarette smokers increase the likelihood of developing peripheral arterial disease. Clinicians should prevent PAD; screen T2DM patients who are aged, with high HbA1c, and cigarette smokers; and treat them timely.

show abstract

Section: Journal Of Diabetes Researchmentioning

confidence: 99%

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Akalu

Birhan

2020

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…As an indicator of long-term blood glucose levels, HbA1c levels are a significant predictor of cardiovascular risk among patients with DM, according to research. Patients with DM who have elevated HbA1c levels have been proven to have a clear correlation with their risk of CVD [ 41 , 42 ]. Our findings revealed no statistically significant difference in blood glucose or HbA1C levels between people with and without CVD.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiovascular Disease Risk in Patients with Type 2 Diabetes Mellitus Using Clinical Laboratory Markers

Ulambayar,

Ghanem,

Chau

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Cardiovascular diseases (CVD) are the main cause of death in the population with diabetes mellitus. This study purposed to determine clinical laboratory markers that might be correlated with the risk of CVD in individuals with type 2 diabetes mellitus (T2DM). Methods: Using data from the Clinical Center of the University of Debrecen from 2016 to 2020, we assessed cardiovascular risk in 5593 individuals with T2DM over a five-year follow-up period. There were 347 new cases of acute myocardial infarction (AMI) and stroke during the period. Following the stratification of these individuals into two groups according to the diagnosis of these CVDs until 2020, the risk of these CVDs was assessed through the utilization of the Chi-square test and Cox proportional hazards regression. Results: The findings of the Cox proportional hazards regression model showed that the number of HbA1C measurements per year (HR = 0.46, 95% CI 0.31–0.7), decreased levels of estimated glomerular filtration rate (eGFR) (HR = 1.6, 95% CI 1.04–2.47), and elevated triglyceride levels (HR = 1.56, 95% CI 1.06–2.29) were correlated with CVD in patients with T2DM. The area under the curve (AUC) was increased from 0.557 (95% CI 0.531–0.582) to 0.628 (95% CI 0.584–0.671) after the inclusion of the laboratory variables into the model showing improved discrimination for AMI and stroke. Conclusions: These findings indicated that eGFR, triglyceride, and the number of HbA1C per year are correlated with AMI and stroke in patients with T2DM.

show abstract

“…25 HbA1C is synthesized from the nonenzymatic glycation reaction of glucose and hemoglobin, and its amount is increased in uncontrolled diabetes. 26 The rise in HbA1C is associated with a stimulated increase in glycation, which aggravates the covalent binding of lipoproteins to vascular wall proteins, leading to free radical release, inflammation, and atherosclerosis. 26,27 On the other hand, Mejias and Ramphul 4 reported no significant difference between both groups regarding HbA1C levels ( P ≥ 0.05).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Peripheral Arterial Disease in Diabetic Foot Ulcer Patients and its Impact in Limb Salvage

Azhar

Basheer

Abdelgawad

et al. 2021

The International Journal of Lower Extremity Wounds

View full text Add to dashboard Cite

Diabetic foot ulcer syndrome is a common complication of diabetes mellitus. Three main factors contribute to it: neuropathy, vasculopathy, and infection. This study was conducted to evaluate the prevalence of peripheral arterial disease (PAD) in diabetic foot ulcer patients and its impact on limb salvage as an outcome. This prospective cross-sectional study included 392 cases, who were divided according to the presence of PAD into 2 groups; patients with PAD were labeled as PAD +ve (172 cases) and those without PAD were labeled as PAD −ve (22 cases). All cases were clinically assessed, and routine laboratory examinations were ordered. Moreover, duplex ultrasound was done for suspected cases of having PAD by examination. Computed tomography angiography was ordered for patients who are in need of a revascularization procedure. Cases were managed by debridement and/or revascularization. After that, these cases were assessed clinically and radiologically for vascularity and infection and the possibility for amputation was evaluated. Infection was classified using Wagner Classification System, and revascularization was decided according to the TASC II system. The incidence of PAD in cases with diabetic foot ulcer syndrome was 43.87%. No difference was detected between the 2 groups regarding age and gender ( P > .05). The prevalence of smoking, hemodialysis, ischemic heart disease (IHD), and hypertension was more significantly higher in cases with PAD ( P < .05). Revascularization procedures were only performed in cases that had documented severe PAD or chronic limb-threatening ischemia in addition to foot ulcer and/or infection. With regard to limb salvage, it was more significantly performed in cases without PAD (82.3% vs 48.3% in PAD cases; P < .001). Male gender, smoking, ankle-brachial pressure index, hemodialysis, IHD, neuropathy, HbA1C, PAD, and high Wagner classification were predictors of limb amputation ( P < .05). PAD is associated with worse outcomes in diabetic foot ulcer patients. Not only does it constitute a great number among diabetic foot ulcer patients, but it also has a negative impact on limb salvage.

show abstract

HbA1c is a risk factor for cardiovascular disease in association with oxidative stress in patients with type 2 diabetes mellitus

Cited by 3 publications

References 32 publications

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Evaluation of Cardiovascular Disease Risk in Patients with Type 2 Diabetes Mellitus Using Clinical Laboratory Markers

Prevalence of Peripheral Arterial Disease in Diabetic Foot Ulcer Patients and its Impact in Limb Salvage

Contact Info

Product

Resources

About