Hawthorn: Potential Roles in Cardiovascular Disease

Chang, Wei‐Tien; Dao, Jenny; Shao, Zuoyi

doi:10.1142/s0192415x05002606

Cited by 130 publications

(95 citation statements)

References 30 publications

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“…Nowadays extracts of Crataegus fruit, leaves and flowers are used for the prevention and treatment of various cardiovascular diseases (hypertension, arrhythmias, congestive heart failure, coronary artery disease, myocardial weakness etc.) due to their positive inotropic and negative chronotropic effects, reduction in coronary spasm, blood pressure and total plasma cholesterol, and for their antioxidant and antiinflammatory properties (Chang et al, 2005;Rigelsky and Sweet, 2002 Nemeikaite-Ceniene et al, 2005, Laughton et al, 1989. Because some of…”

Section: Discussionmentioning

confidence: 99%

The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart

Bernatonienė

Trumbeckaitė

Majienė

et al. 2009

Phytotherapy Research

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To cite this version:Jurga Bernatoniene, Sonata Trumbeckaite, Daiva Majiene, Rasa Baniene, Giedre Baliutyte, et al.. The effect of Crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart. Phytotherapy Research, Wiley, 2009, 23 (12) ng/ml to 13.9 µg/ml of Crataegus phenolic compounds (PC)) and its several pure flavonoids on isolated rat heart mitochondria respiring on pyruvate+malate, succinate and palmitoyl-L-carnitine+malate. CE at doses under 278 ng/ml of PC had no effect on mitochondrial functions. At concentrations from 278 ng/ml to 13.9 µg/ml of PC, CE

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Section: Discussionmentioning

confidence: 99%

The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart

Bernatonienė

Trumbeckaitė

Majienė

et al. 2009

Phytotherapy Research

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“…As we know, oxidation of the low-density lipoprotein (LDL) cholesterol plays an important role in atherosclerosis [73]. This accumulation causes a cascade of inflammatory processes, resulting in an unstable atherosclerotic plaque that ultimately bursts, causing myocardial infarction [74].…”

Section: Cardiovascular Effectmentioning

confidence: 99%

“…The use of hawthorn for the treatment of cardiovascular heart disease dates back to the late 1800s [6, 7]. Current claims suggested that hawthorn could be used as an alternative therapy for various cardiovascular diseases, such as angina, hypertension, hyperlipidemia, arrhythmia, and New York Heart Association (NYHA) functional class II congestive heart failure [8, 9]. Nowadays, it is gaining attention for its potential cardiovascular enhancing and protective properties [10] and numerous laboratory tests and clinical trials have demonstrated hawthorn's efficacy in the treatment or prevention of cardiovascular diseases and the most substantial evidence for clinical benefits of hawthorn is its use in chronic congestive heart failure (CHF) [11].…”

Section: Introductionmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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“…1,2) These extracts exert several pharmacological and clinical effects, such as antiischemia/reperfusion-injury, anti-arrhythmic, hypolipidemic, and hypotensive effects. 1,2) Flavonoids and procyanidins are considered to be the two main active constituents. 2) Species of Chinese hawthorn, particularly Crataegus pinnatifida and Crataegus pinnatifida Bge.…”

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confidence: 99%

Polyphenolic Content and Physiological Activities of Chinese Hawthorn Extracts

Cui

Nakamura

Tian

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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Hawthorn polyphenol (HP) was prepared by ethyl acetate treatment of the ethanol extract (HE) of Chinese hawthorn fruit. The concentrations of 15 polyphenols in the HP, HE, extraction residue (HJ), and a hawthorn leaf extract (HF) were determined by HPLC. For HP, the total content of the 15 polyphenols was 21.4%, comprised of 19.7% of procyanidins, 1.21% of chlorogenic acid, and 0.48% of flavonoids, compared to 2.55% for the HE. The yields of procyanidin monomer, dimer, trimer, tetramer, and pentamer were 50.5%, 30.3%, 23.0%, 14.6%, and 12.5% respectively, and the mean degree of polymerization was reduced to 1.39 (HP) from 1.65 (HE). Seven different physiological actions of the four extracts were investigated. The HP showed strong O 2 À and OH scavenging capacities (IC 50 values of 6.3 g/ml and 1.1 g/ml respectively), as well as selective prolyl endopeptidase inhibition (IC 50 of 60 g/ml). The active constituents appeared to be procyanidins.Key words: Crataegus pinnatifida; HPLC; procyanidin; antioxidant; free radicalsIn Europe, standardized extracts of the leaves and flowers of Crataegus oxyacantha and Crataegus monogyna are used in the therapy for moderate (NYHA II) congestive heart failure. 1,2) These extracts exert several pharmacological and clinical effects, such as antiischemia/reperfusion-injury, anti-arrhythmic, hypolipidemic, and hypotensive effects. 1,2) Flavonoids and procyanidins are considered to be the two main active constituents. 2) Species of Chinese hawthorn, particularly Crataegus pinnatifida and Crataegus pinnatifida Bge. var. major NE Br., have also been used as herbal medicines. 2,3) Studies indicate that Chinese hawthorn extracts have beneficial effects, such as antioxidant, 4,5) anti-inflammatory, 6) and hypolipidemic effects, 7) as well as protective effects on the brain and vascular endothelium 8,9) and endothelium-dependent relaxation. 10) Recently, we analyzed 37 major cultivars of Chinese hawthorn using high performance liquid chromatography (HPLC), and found that procyanidins, which were present in high concentrations, were the main phenolic active constituents in these fruits. 11) In general, the hawthorn found in China is an edible fruit that is popular for its special acidic taste. It is bigger than its European counterpart. Since the content of organic acid in Chinese hawthorn fruits can be up to 5% (fresh weight), they are used to produce various foods, such as jams, jellies, juices, tinned foods, wines, and various sweet foods. However, the high sugar content of these fruits counteracts the benefits of polyphenols for consumers of advanced age or for those who suffer from hypertension, cardiovascular disease, or diabetes. Hence, it is desirable to separate the polyphenol and sugar components. Previously, hawthorn extract (HE) for medical applications were ethanol-extracted from the dried fruit of the Chinese hawthorn. 12) These crude extracts contain many undesirable substances, such as carbohydrates, organic acids, and moisture, which not only reduce the concentration of acti...

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Hawthorn: Potential Roles in Cardiovascular Disease

Cited by 130 publications

References 30 publications

The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart

The effect of crataegus fruit extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Polyphenolic Content and Physiological Activities of Chinese Hawthorn Extracts

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