Abstract:Hawthorn extract has been used for ameliorating cardiac disorders and pulmonary hypertension. Flavonoids and oligomeric proanthocyanidins are considered to be responsible for the positive health effects of hawthorn extract. The effect of Hawthorn extract in the water supply on feed intake, growth, carcass traits, internal organ weight, cardiac indices, the concentration of serum proteins and the incidence of pulmonary hypertension syndrome was evaluated in broiler chickens. At one day-of-age, 225 chickens were… Show more
“…16 Greater production of ROS in chickens was reported due to their susceptibility to oxidative stress. 1,2 Bioactive compounds in HFE can contribute to the protective roles against oxidative stress, lipid peroxidation and increasing activity of serum antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and catalase, which counteract the oxidative stress. [4][5][6][7] So decreased in percentage of affected birds with PHS is concerned to presence of epicatechin, hyperoside, and chlorogenic acid as potent antioxidants and free radical scavenging agents to harness oxidative damages caused by PHS and other cardiovascular lesions.…”
Section: Resultsmentioning
confidence: 99%
“…1 Also intensive genetic improvement of growth traits in broiler chickens has created a situation where the development and end size of the heart and lung is unsynchronized and leads to increasing the sensitivity of broilers to pulmonary hypertension and right ventricular failure. 2 At high altitudes with low partial oxygen pressure, the sensitivity of broilers to PHS will increase and finally leads to right ventricular failure and ascite. 3 Crataegus oxyacantha (Hawthorn) as a famous medical plant is traditionally used in treatment of cardiac diseases and cardiovascular problems.…”
An experiment was conducted to investigate the effect of hawthorn flavonoid extract (HFE) to prevent pulmonary hypertension in broiler chickens. A total of 225 day-old unsexed broiler chicks (Ross308) were assigned to 3 treatments with five replicates in 15 floor pens randomly. Experimental groups were provided by adding 0, 0.1 and 0.2 mL of hawthorn flavonoid extract per liter of chicken's drinking water. The results showed that HFE significantly (P<0.05) decreased the heart weight, RV: TV ratio, and percentage of birds with PHS compared to the control group. In conclusion, HFE could effectively use as an herbal drug to prevent pulmonary hypertension in chickens.
“…16 Greater production of ROS in chickens was reported due to their susceptibility to oxidative stress. 1,2 Bioactive compounds in HFE can contribute to the protective roles against oxidative stress, lipid peroxidation and increasing activity of serum antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and catalase, which counteract the oxidative stress. [4][5][6][7] So decreased in percentage of affected birds with PHS is concerned to presence of epicatechin, hyperoside, and chlorogenic acid as potent antioxidants and free radical scavenging agents to harness oxidative damages caused by PHS and other cardiovascular lesions.…”
Section: Resultsmentioning
confidence: 99%
“…1 Also intensive genetic improvement of growth traits in broiler chickens has created a situation where the development and end size of the heart and lung is unsynchronized and leads to increasing the sensitivity of broilers to pulmonary hypertension and right ventricular failure. 2 At high altitudes with low partial oxygen pressure, the sensitivity of broilers to PHS will increase and finally leads to right ventricular failure and ascite. 3 Crataegus oxyacantha (Hawthorn) as a famous medical plant is traditionally used in treatment of cardiac diseases and cardiovascular problems.…”
An experiment was conducted to investigate the effect of hawthorn flavonoid extract (HFE) to prevent pulmonary hypertension in broiler chickens. A total of 225 day-old unsexed broiler chicks (Ross308) were assigned to 3 treatments with five replicates in 15 floor pens randomly. Experimental groups were provided by adding 0, 0.1 and 0.2 mL of hawthorn flavonoid extract per liter of chicken's drinking water. The results showed that HFE significantly (P<0.05) decreased the heart weight, RV: TV ratio, and percentage of birds with PHS compared to the control group. In conclusion, HFE could effectively use as an herbal drug to prevent pulmonary hypertension in chickens.
“…Many plant extracts and phytochemicals do its effects by suppressing ET-1 expression and following that MMP-2 and MMP-9 expression which cause inhibition of the progression of vascular remodeling. Some of these plant extracts and phytochemicals include C. rhipidophylla, K. odoratissima, S. miltiorrhiza, T. pratense, asiaticoside, baicalin, ginsenoside Rb1, punicalagin and resveratrol; that have vascular antiremodeling effect and this way inhibit the progression of PH (Chen et al, 2003;Ahmadipour et al, 2015;He et al, 2015;Jiang and Yang, 2016;Xu et al, 2016;Ahmadipour et al, 2017;Guan et al, 2017;Hsu et al, 2018;Wang et al, 2018;Ahmadipour et al, 2019). d. Vasodilator: One of the important reasons for PH is increased blood vessel contraction and after that PH.…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with C. rhipidophylla extract mix in drinking water of broiler chickens with pulmonary hypertension syndrome (PHS) induced by high altitude suggested that the extract cause an increase in albumin, globulin, food intake and body weight and a decrease in AST, ALT, ALP, and RV : TV ratio (Ahmadipour et al, 2017). ALP is one of the serum's enzymes which is a marker of liver tissue damage and the two liver enzymes, AST and ALT, increase their concentrations in oxidative stress conditions and hypoxic state before PHS.…”
Section: Crataegus Rhipidophylla Gandmentioning
confidence: 99%
“…These liver enzymes are sensitive markers for measuring oxidative stress, which is an important factor during PHS progression (Fathi et al, 2011). Therefore, the decrease in ALP, ALT and AST levels show reduction of tissue damage due to oxidative stress and that could lead to inhibition of PHS progression (Ahmadipour et al, 2017).…”
Background: Pulmonary hypertension (PH) is a progressive disease that is associated with pulmonary arteries remodeling, right ventricle hypertrophy, right ventricular failure and finally death. The present study aims to review the medicinal plants and phytochemicals used for PH treatment in the period of 1994-2019. Methods: PubMed, Cochrane and Scopus were searched based on pulmonary hypertension, plant and phytochemical keywords from August 23, 2019. All articles that matched the study based on title and abstract were collected, non-English, repetitive and review studies were excluded. Results: Finally 41 studies remained from a total of 1290. The results show that many chemical treatments considered to this disease are ineffective in the long period because they have a controlling role, not a therapeutic one. On the other hand, plants and phytochemicals could be more effective due to their action on many mechanisms that cause the progression of PH. Conclusion: Studies have shown that herbs and phytochemicals used to treat PH do their effects from six mechanisms. These mechanisms include antiproliferative, antioxidant, antivascular remodeling, anti-inflammatory, vasodilatory and apoptosis inducing actions. According to the present study, many of these medicinal plants and phytochemicals can have effects that are more therapeutic than chemical drugs if used appropriately.
BackgroundOne of the main problems in the poultry industry is excess body fat, and the anti‐fat effect of Cratagus extract has been confirmed in several studies.ObjectivesThe present study was carried out to investigate the effects of hawthorn extract (Crataegus oxyacantha) on growth performance, haematological variables and hepatic gene expression in broiler chickens reared at high altitude (2100 m).MethodsA total of 225‐day‐old chicks (Ross 308) were randomly distributed into three treatments. Experimental treatments were prepared by adding 0.0, 0.2 and 0.4 mL of hawthorn extract per litre of consumption of water.ResultsThe results showed that weight gain and feed conversion ratio were significantly improved and abdominal fat decreased by consumption of two levels of Crateagus extract when compared to the control (p < 0.05). Consumption of hawthorn extract decreased circulatory levels of malondialdehyde, triacylglycerol, total cholesterol and low‐density lipoproteins cholesterol but increased ferric reducing antioxidant power and high‐density lipoproteins cholesterol (p < 0.05). Hawthorn extract caused an up‐regulation of catalase, superoxide dismutase1, glutathione peroxidase1 and peroxisome proliferator‐activated receptor alpha but reduced the expression of key lipogenic enzymes (p < 0.05).ConclusionsOverall, consumption of 0.4 mL hawthorn extract per litre of drinking water, improved growth performance, suppressed lipogenesis and enhanced antioxidant response.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.