Hatching success and survival of fish early life stages in a chronic exposure to nevirapine: a case study of the Mozambique tilapia

Nibamureke, U. M. C.; Barnhoorn, I.E.J.; Wagenaar, G.M.

doi:10.1080/09603123.2018.1548697

Cited by 6 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chronic toxicity test performed for nevirapine was presented in a paper by Nibamureke et al (2019). The maximum concentration of the drug found in raw water in South Africa was used in the study, which was 1.48x10 -6 mg/L, determined as NOEC.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Environmental elimination estimate and literature review of ecotoxicological aspects of the main widely used antiretrovirals in Brazil

Souza

Ribeiro

Soares

et al. 2022

RSD

View full text Add to dashboard Cite

Objective: To estimate the consumption and quantity of unaltered antiretrivirals (ARV) eliminated into the environment and to carry out a literature research on aquatic ecotoxicological studies of ARV used in Brazil. Methodology: We requested from one of the ARV dispensing units in the city of Belo-Horizonte (BH) the amount of ARV dispensed in the years 2018-2019-2020. Considering the amount dispensed in 2020, the daily dose, and the elimination rate, the amount of drug in unchanged form in the environment was estimated. For entire municipality of BH and Brazil, we used epidemiological data were used regarding individuals using antiretroviral therapy (ART) in 2020, the proportion of people living with HIV using the main ART regimen, following the same estimation methodology used previously. Structured and individual searches were carried out for each ARV used in Brazil, relating it to ecotoxicology, through Google Scholar, National Center for Biotechnology Information and Scifinder, in addition to the use of the fass.se platform. Results: Four articles presented results of acute or chronic toxicity in ecotoxicological models involving ARV. Dolutegravir and efavirenz were found to be highly toxic in ecotoxicological models. In 2020, approximately 2,167kg of ARVs in unchanged form were released into the environment in BH. In Brazil it was 112,274kg. Conclusion: It is urgent to quantify the main ARV in water bodies. With these data together with ecotoxicological data it will be possible to establish risk criteria for possible measures to control or mitigate these contaminants in the environment, especially actions to improve wastewater/water treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The study followed OECD guidelines for toxicity testing. It is worth noting that this was the only concentration evaluated (Nibamureke et al, 2019). There are no acute toxicity studies for the species of fish used in the study cited.…”

Section: Resultsmentioning

confidence: 99%