¿Hasta dónde llega la precocidad de la tomografía de coherencia óptica en el deterioro cognitivo?

Gimenez-Castejon, D; Gómez-Gallego, M; Martínez-Martínez, ML; Dudekova, M; Lajara-Blesa, Jerónimo

doi:10.33588/rn.6301.2016003

Cited by 2 publications

(5 citation statements)

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“…The macular area, which was recently analysed, demonstrated a significant decrease in the thickness of this retinal region in patients with AD with respect to controls [24,62,71,76,77,82–87]. However, in some studies, when analysing the foveal area, a non-significant thickening was found in patients with AD [24,84].…”

Section: Discussionmentioning

confidence: 99%

Changes in visual function and retinal structure in the progression of Alzheimer's disease

et al. 2019

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Background Alzheimer’s Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT). Methods We included 39 patients with mild AD, 21 patients with moderate AD and 40 age-matched healthy controls. Both patients and controls were ophthalmologically healthy. Visual acuity, contrast sensitivity, colour perception, visual integration, and choroidal thicknesses were measured. In addition, OCT and OCT angiography (OCTA) were applied. Findings Visual acuity, contrast sensitivity, colour perception, and visual integration were significantly lower in AD patients than in healthy controls. Compared to healthy controls, macular thinning in the central region was significant in the mild AD patients, while macular thickening in the central region was found in the moderate AD group. The analysis of macular layers revealed significant thinning of the retinal nerve fibre layer, the ganglion cell layer and the outer plexiform layer in AD patients relative to controls. Conversely, significant thickening was observed in the outer nuclear layer of the patients. However, mild AD was associated with significant thinning of the subfovea and the nasal and inferior sectors of the choroid. Significant superonasal and inferotemporal peripapillary thinning was observed in patients with moderate disease. Conclusions The first changes in the mild AD patients appear in the psychophysical tests and in the central macula with a decrease in the central retinal thickness. When there was a disease progression to moderate AD, psychophysical tests remained stable with respect to the decrease in mild AD, but significant thinning in the peripapillary retina and thickening in the central retina appeared. The presence of AD is best indicated based on contrast sensitivity.

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Section: Discussionmentioning

confidence: 99%

Changes in visual function and retinal structure in the progression of Alzheimer's disease

et al. 2019

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“…According to Alzheimer's disease (AD) International, 50 million people worldwide suffer from dementia, and given the anticipated increase in life expectancy, the prevalence is expected to continue rising exponentially up to 152 million in 2050 1 . AD, is the most frequent cause of dementia (60%–70% of total cases) 2 3 …”

Section: Introductionmentioning

confidence: 99%

“…Patients with mild cognitive impairment (MCI) sometimes remain in a stable clinical situation for decades, although a few patients with MCI appear to have a higher risk of developing dementia, and particularly AD, compared to the general population 2 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…1 AD, is the most frequent cause of dementia (60%-70% of total cases). 2,3 Patients with mild cognitive impairment (MCI) sometimes remain in a stable clinical situation for decades, although a few patients with MCI appear to have a higher risk of developing dementia, and particularly AD, compared to the general population. 2,[4][5][6] Early diagnosis of AD using innocuous but efficient biomarkers is a current challenge for researchers and clinicians.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Patients with mild cognitive impairment (MCI) sometimes remain in a stable clinical situation for decades, although a few patients with MCI appear to have a higher risk of developing dementia, and particularly AD, compared to the general population. 2,[4][5][6] Early diagnosis of AD using innocuous but efficient biomarkers is a current challenge for researchers and clinicians. 4 Neuropsychological evaluation plays a key role in the diagnosis of AD, though it requires time and multiple studies and should be performed by expert evaluators.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

Carazo-Barrios

Archidona‐Arranz

Claros‐Ruiz

et al. 2021

Int J Geriat Psychiatry

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Objectives Early diagnosis in Alzheimer's disease (AD) is crucial in order to implement new therapeutic strategies. The retina is embryologically related to the brain. Thus, the possible usefulness of optical coherence tomography (OCT) in the early detection of AD is currently being studied. Our aim was to study the relationship between retinal nerve fiber layer (RNFL) thickness and AD. Methods We undertook an observational, analytical, cross‐sectional study with consecutive sampling of 32 patients with AD or mild cognitive impairment and a group of healthy controls (C). The total number of eyes studied was 64. An ophthalmological and a comprehensive neuropsychological evaluation were performed in all participants. Quantification of white matter lesions and study of atrophy of the hippocampus by cerebral magnetic resonance were also performed. Results We observed a significant linear trend towards a thinning of RNFL as the degree of cognitive deterioration increased, in the superior and temporal quadrants of the retina. A significant correlation was also noted between the mean thickness of the RNFL of the left temporal quadrant and occipital white matter lesions (r = −0.579, p = 0.038). Conclusions OCT could be a safe, rapid noninvasive tool providing useful biomarkers in the early detection of cognitive deterioration and AD.

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¿Hasta dónde llega la precocidad de la tomografía de coherencia óptica en el deterioro cognitivo?

Cited by 2 publications

References 0 publications

Changes in visual function and retinal structure in the progression of Alzheimer's disease

Changes in visual function and retinal structure in the progression of Alzheimer's disease

Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

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