Hashimoto Thyroiditis Coexistent with Papillary Thyroid Carcinoma

Abstract

Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating a possible correlation between the two diseases. We studied a group of 89 subjects undergoing surgery for thyroid carcinomas compared with a control group of 89 subjects operated on for normofunctioning goiter, and a second group of 47 patients undergoing total thyroidectomy for HT. Association with HT was found in 19 of the 71 PTC subjects (26.7%) and in 8 goiter patients (8.9%), which was a significant difference ( P < 0.02). Thirteen of the HT patients, mostly with the nodular form, showed coexistent PTC (27.6%). HT and PTC coexisted in several morphological, immunohistochemical, and biomolecular aspects; increased incidence of PTC in HT patients might therefore indicate that HT is a precursor of thyroid cancer. Further studies are required, however, in order to confirm this hypothesis; until then, HT patients should undergo careful clinical and technical follow-up.

Sonography of diffuse thyroid disease

“…A strong association is identified between thyroid non‐Hodgkin lymphoma and antecedent Hashimoto thyroiditis . There are also reports suggesting increased risk of papillary carcinoma in Hashimoto thyroiditis . Therefore, during sonographic examination of patients with Hashimoto thyroiditis, care must be taken to evaluate for lesions suspicious of thyroid malignancy.…”

Carcinoma papilífero da tireoide e suas variantes histológicas associados à tireoidite de Hashimoto

“…Discussão Desde a década de 1980, já existem estudos nos quais se demonstrava a coexistência entre TH e carcinoma papilífero da tireoide (25) . O presente estudo evidenciou uma coexistência de 30%, (Figura), resultado que ratifica estudos anteriormente relatados como Cipolla (4) e Roberti (4,22) . Isso sugere uma relação não apenas casual, mas possivelmente que a presença de processo inflamatório crônico com ativação de genes relacionados à multiplicação celular poderia ser mais um fator para a transformação maligna.…”

“…Desse modo, ainda não está claro se a coexistência da TH denota pior prognóstico da neoplasia tireoidiana, e estudos posteriores devem ser realizados visando determinar a evolução da doença, que a princípio poderia ter sido desencadeada pela inflamação crônica da tireoide (4,21) .…”

“…A associação entre o carcinoma papilífero e suas variantes e a TH é bastante questionada no meio científico, pois compartilham diversos aspectos morfológicos, imuno-histoquímicos e biomoleculares (2,4) .…”

Coexistence of Hashimoto's thyroiditis with papillary carcinoma thyroid: A rare case report with review of literature

“…2 Several studies report a higher rate of papillary thyroid carcinoma in patients with Hashimoto's thyroiditis indicating possible correlation between the two diseases. [3][4][5] There is approximately 30% frequency of the coexistence of Hashimoto's thyroiditis and differentiated thyroid carcinoma. The presence of coexistent Hashimoto's thyroioditis does not affect the diagnostic evaluation and management of papillary thyroid cancer.…”