Has the Phase of the Menstrual Cycle Been Considered in Studies Investigating Pressure Pain Sensitivity in Migraine and Tension-Type Headache: A Scoping Review

Curiel-Montero, Francisca; Alburquerque‐Sendín, Francisco; Fernández‐de‐las‐Peñas, César; Rodrigues-de-Souza, Daiana Priscila

doi:10.3390/brainsci11091251

Cited by 5 publications

(3 citation statements)

References 90 publications

(262 reference statements)

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“…Pain sensation is higher in the luteal phase than in the follicular phase and during menstruation. 23 According to molecular biology studies, decreased estrogen causes the hypothalamus to release norepinephrine, which triggers a drop in acetylcholine, dopamine, and serotonin, which can lead to premenstrual syndrome with common symptoms such as pain sensitivity, insomnia, fatigue, and depression. 24 The fact that the GABAergic system, which affects neuronal excitability, is associated with estrogen and progesterone levels that change during menstrual phases explains the change in perception of pain sensation during menstrual phases.…”

Section: Discussionmentioning

confidence: 99%

The Menstrual Cycle Phase and Effect of Aromatherapy on Orthodontic Debonding Pain

DEMİRSOY

Büyük

Imamoglu

2022

Cumhuriyet Dental Journal

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Objectives: The aim of this prospective clinical study was to evaluate the effects of the menstrual cycle phases and aromatherapy on women's perception of orthodontic debonding pain. Materials and Methods: The materials of our study were consisted of randomly selected 48 female patients (mean age:19.00±3.40). Four different study groups were performed. LA+; the patients in the luteal phase and received aromatherapy(n=12), LA-; the patients in the luteal phase and did not receive aromatherapy(n=13), FA+; the patients in the follicular phase and received aromatherapy(n=11), FA-; the patients in the follicular phase and did not receive aromatherapy(n=12). Debonding was performed and the pain experience for each tooth was scored by the patient on a visual analogue scale (VAS). Also, participants' general responses to pain were assessed with the Pain Catastrophizing Scale (PCS). The aromatherapy protocol was to inhale lavender oil from approximately 30 cm for 3 minutes, 3 minutes before debonding. Results: It was found that the mean VAS scores were higher in the luteal phase than in the follicular phase, however this difference was not statistically significant. There was no statistically significant difference between the groups with and without aromatherapy in terms of VAS scores(P>0.05). The correlation between total PCS scores and total VAS scores was statistically significant (r=0.310, P

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Section: Discussionmentioning

confidence: 99%

The Menstrual Cycle Phase and Effect of Aromatherapy on Orthodontic Debonding Pain

DEMİRSOY

Büyük

Imamoglu

2022

Cumhuriyet Dental Journal

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“…Fixed-effects were included for four experimental factors that were all considered to be continuous variables: Headache intensity (scale from 0 (no pain) to 10 (extremely painful) score), state anxiety (scores from 20 to 80, with higher scores denoting greater anxiety) (26), sleep quality (scores from 1 to 4, with higher scores denoting worse sleep quality), and tolerance to stimuli over time (ranging from 1 to 27 days, with the latter being the end day). Anxiety (32,33), sleep quality (34,35), tolerance (36), menstruation (37,38) and medication intake (39) have been linked to the modulation of pain thresholds in past studies. Menstruation and medication intake were not included in the models as a result of a low number of observations in one condition.…”

Section: Methodsmentioning

confidence: 99%

Quantifying sensory thresholds along the migraine cycle: An exploratory longitudinal study

Ikumi,

Marti-Marca,

Torre-Suñe

et al. 2024

Cephalalgia

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Background To date, a number of studies on migraine have cross-sectionally evaluated sensory sensitivity with aversion thresholds/scores along the migraine cycle, reporting a decreased tolerance to sensory stimuli in different sensory modalities. Our hypothesis was that patients with migraine would exhibit heightened sensitivity to sound, light, touch and smell on days where they reported greater headache intensity. Methods This is an exploratory, longitudinal study, carried out over the course of 27 days. Aversion thresholds or scores to sound, light, touch and smell were quantified in six patients with migraine (11.33 ± 6.53 headache days/month). Results Patients reported an increased sensitivity to light ( padj = 0.0297), touch ( padj = 0.0077), and smell (padj = 0.0201) on days with higher headache intensity. However, a greater sensitivity to sound on days with higher headache intensity was only reported when anxiety levels were high ( padj = 1.4e−06). Interestingly, variable levels of tolerance to bothersome light over time can also influence the correlation between light sensitivity and headache intensity ( padj = 1.4e−06). Conclusions Based on the present findings, future longitudinal studies evaluating sensory threshold changes along the migraine cycle in patients with migraine should account for the increased tolerance to bothersome light over time as well as the effect of anxiety on auditory sensitivity.

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“…Although all studies applied ICHD criteria, not all studies clearly reported the severity/frequency of migraine attacks and consecutiveness of patients. Third, the number of studies investigating PPT separately in women and men was limited and most studies did not control the menstrual phase in women, a topic recently discussed (46). Accordingly, current PPTs stratified by sex should be considered with caution.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis

Fernández‐de‐las‐Peñas

Navarro-Santana

Curiel-Montero

et al. 2022

Cephalalgia

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Objective This meta-analysis compared pressure pain sensitivity in trigeminal, cervical spine and remote pain-free areas between migraine patients and headache-free controls considering diagnosis (episodic versus chronic) and sex. Databases and data treatment: Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds between migraine and headache-free controls. Data were extracted by two reviewers. The risk of bias and methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (cervical spine) and remote pain-free areas were compared. Frequency of migraine and sex were taken into account. Mean differences (MD) and random effects were calculated. Results Eighteen studies were included. Patients with migraine showed lower pressure pain thresholds than headache-free controls: trigeminal (MD −71.33 kPa, 95%CI −92.14 to −50.53), cervical spine (MD −68.50 kPa, 95%CI −84.67 to −52.33), and remote pain-free (MD −62.49 kPa, 95%CI −99.52 to −25.45) areas. Differences were consistently significant for episodic migraine in all locations, but only significant in the trigeminal area for chronic migraine (MD −67.36 kOPa, 95%CI −101.31 to −33.42). Overall, women had lower pressure pain thresholds than men. The methodological quality of most studies (66.7%) was good. The results showed a high heterogeneity. Conclusion This meta-analysis found low to high quality evidence showing lower pressure pain thresholds in trigeminal, extra-trigeminal, and remote pain-free areas in migraine sufferers when compared with headache-free controls. Hypersensitivity to pressure pain locally and widespread was consistently observed in episodic migraine, but locally in chronic migraine as compared to headache-free controls. Women with migraine were more sensitive than men. Registration number: https://doi.org/10.17605/OSF.IO/YJTAK

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Has the Phase of the Menstrual Cycle Been Considered in Studies Investigating Pressure Pain Sensitivity in Migraine and Tension-Type Headache: A Scoping Review

Cited by 5 publications

References 90 publications

The Menstrual Cycle Phase and Effect of Aromatherapy on Orthodontic Debonding Pain

The Menstrual Cycle Phase and Effect of Aromatherapy on Orthodontic Debonding Pain

Quantifying sensory thresholds along the migraine cycle: An exploratory longitudinal study

Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis

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