Harnessing diverse transcriptional regulators for natural product discovery in fungi

Lyu, Haining; Liu, Hongwei; Keller, Nancy P.; Yin, Wen‐Bing

doi:10.1039/c8np00027a

Cited by 80 publications

(86 citation statements)

References 76 publications

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“…Molds species from genera Aspergillus , Fusarium and Penicillium predominantly produce these bioactive secondary metabolites (SMs) (Keller, ). A survey showed that more than 1,500 compounds have been isolated from molds, and more than half of these compounds exhibited antimicrobial and/or antitumor activity (Lyu, Liu, Keller & Yin, ). This suggests that molds harbor an enormous secondary metabolome with potential applications for drug discovery (Schueffler & Anke, ).…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide as a developmental and metabolic signal in filamentous fungi

Zhao

Lim

et al. 2020

Molecular Microbiology

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The short‐lived hydrophobic gas nitric oxide (NO) is a broadly conserved signaling molecule in all domains of life, including the ubiquitous and versatile filamentous fungi (molds). Several studies have suggested that NO plays a vast and diverse signaling role in molds. In this review, we summarize NO‐mediated signaling and the biosynthesis and degradation of NO in molds, and highlight the recent advances in understanding the NO‐mediated regulation of morphological and physiological processes throughout the fungal life cycle. In particular, we describe the role of NO in molds as a signaling molecule that modulates asexual and sexual development, the formation of infection body appressorium, and the production of secondary metabolites (SMs). In addition, we also summarize NO detoxification and protective mechanisms against nitrooxidative stress.

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Section: Introductionmentioning

confidence: 99%

Nitric oxide as a developmental and metabolic signal in filamentous fungi

Zhao

Lim

et al. 2020

Molecular Microbiology

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“…In working with the discovery of natural products, several research approaches have been reported to be involved in both secondary metabolism and fungal development [ 50 , 51 ]. It is urgent to find new approaches to distinguish new products from the known compounds.…”

Section: Discussionmentioning

confidence: 99%

Discovery of New Secondary Metabolites by Epigenetic Regulation and NMR Comparison from the Plant Endophytic Fungus Monosporascus eutypoides

Guo

Zou

2020

Molecules

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Overexpression of the histone acetyltransferase and the 1H NMR spectroscopic experiments of the endophytic fungus Monosporascus eutypoides resulted in the isolation of two new compounds, monosporasols A (1) and B (2), and two known compounds, pestaloficin C (3) and arthrinone (4). Their planar structures and absolute configurations were determined by spectroscopic analysis including high resolution electrospray ionization mass spectroscopy (HRESIMS), one-dimensional (1D) and two-dimensional (2D) NMR, and calculated electronic circular dichroism data. Compounds 1–2 were screened in cytotoxic bioassays against HeLa, HCT-8, A549 and MCF-7 cells. Our work highlights the enormous potential of epigenetic manipulation along with the NMR comparison as an effective strategy for unlocking the chemical diversity encoded by fungal genomes.

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“…These sources can be either complex mixtures extracted from raw materials or single compounds. 2,3 Among the well-known medicinal fungi, Ganoderma lucidum (Curtis) P. Karst. and other species of Ganoderma showed greater advantages than other chemical drugs.…”

Section: Introductionmentioning

confidence: 99%

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

Wang

Zhang

et al. 2020

RSC Adv.

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Harnessing diverse transcriptional regulators for natural product discovery in fungi

Abstract: This review covers diverse transcriptional regulators for the activation of secondary metabolism and novel natural product discovery in fungi.

Cited by 80 publications

References 76 publications

Nitric oxide as a developmental and metabolic signal in filamentous fungi

Nitric oxide as a developmental and metabolic signal in filamentous fungi

Discovery of New Secondary Metabolites by Epigenetic Regulation and NMR Comparison from the Plant Endophytic Fungus Monosporascus eutypoides

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

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