Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

Kaur, Jaskiran; Mishra, Vijay; Singh, Sachin Kumar; Gulati, Monica; Kapoor, Bhupinder; Chellappan, Dinesh Kumar; Gupta, Gaurav; Dureja, Harish; Anand, Krishnan; Dua, Kamal; Khatik, Gopal L.; Kuppusamy, Gowthamarajan

doi:10.1016/j.jconrel.2021.04.014

Cited by 66 publications

(33 citation statements)

References 249 publications

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“…Amphiphilic block copolymers are linear copolymers that consist of two or more polymer chains with different chemical structures and properties, including hydrophilic and hydrophobic chain segments in the same molecular chain. 17 These polymers are characterized by controllable molecular weight, narrow molecular weight distribution, programmable molecular structure and composition, easy surface modification, and enhanced permeability and retention (EPR) effects; 18 the incompatibility of their hydrophilic and hydrophobic chain segments can lead to microphase separation, which will make amphiphilic polymers exhibit self-assembly characteristics in selective solvents, bulk, surface, and interface structures. 19 The excellent properties of various polymers can be combined to obtain superior functional polymer materials.…”

Section: Amphiphilic Block Copolymer-based Self-assembled Drug Delive...mentioning

confidence: 99%

Research progress on self-assembled nanodrug delivery systems

Li¹,

Yang²,

Gao³

et al. 2022

J. Mater. Chem. B

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Section: Amphiphilic Block Copolymer-based Self-assembled Drug Delive...mentioning

confidence: 99%

Research progress on self-assembled nanodrug delivery systems

Li¹,

Yang²,

Gao³

et al. 2022

J. Mater. Chem. B

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“…Polymeric micelles are self-assembling nanostructures 1–100 nm in diameter ( Kaur et al., 2021 ), thus making them ideal carriers for BC delivery. Micelles’ small particle sizes allow them to evade the reticulo-endothelial system in the circulation and accumulate at tumor sites via enhanced permeation and retention ( Rao et al., 2019 ).…”

Section: Ligands Used To Target Carriers To Mdr Bc Cellsmentioning

confidence: 99%

“…Micelles’ small particle sizes allow them to evade the reticulo-endothelial system in the circulation and accumulate at tumor sites via enhanced permeation and retention ( Rao et al., 2019 ). Self-assembly of amphiphilic copolymers leads to the formation of micelles with hydrophobic anticancer agents trapped in the core ( Kaur et al., 2021 ). The copolymers are readily conjugated with targeting moieties to enable site-specific accumulation in cancer cells ( Keskin and Tezcaner, 2017 ).…”

Section: Ligands Used To Target Carriers To Mdr Bc Cellsmentioning

confidence: 99%

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Famta

Shah

Chatterjee

et al. 2021

Current Research in Pharmacology and Drug Discovery

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The high probability (13%) of women developing breast cancer in their lifetimes in America is exacerbated by the emergence of multidrug resistance after exposure to first-line chemotherapeutic agents. Permeation glycoprotein (P-gp)-mediated drug efflux is widely recognized as the major driver of this resistance. Initial in vitro and in vivo investigations of the co-delivery of chemotherapeutic agents and P-gp inhibitors have yielded satisfactory results; however, these results have not translated to clinical settings. The systemic delivery of multiple agents causes adverse effects and drug–drug interactions, and diminishes patient compliance. Nanocarrier-based site-specific delivery has recently gained substantial attention among researchers for its promise in circumventing the pitfalls associated with conventional therapy. In this review article, we focus on nanocarrier-based co-delivery approaches encompassing a wide range of P-gp inhibitors along with chemotherapeutic agents. We discuss the contributions of active targeting and stimuli responsive systems in imparting site-specific cytotoxicity and reducing both the dose and adverse effects.

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“…Polymeric micelles are formed by amphiphilic block copolymers with hydrophilic and hydrophobic units, which can self-assemble in aqueous media above the critical micelle concentration (CMC) into unique and stable core-shell structures and are driven by a decrease in interfacial free energy [13,14]. Their hydrophobic core promotes the solubilization of water-insoluble drugs, protecting them from degradation by harsh environments, whereas their outer hydrophilic shell can reduce the binding of plasma proteins and minimize nonspecific uptake by the reticuloendothelial system (RES), prolonging their blood circulation time [15]. Naturally occurring polysaccharides used as a hydrophilic block, such as alginate, dextran, chitosan, heparin, hyaluronic acid and chondroitin sulfate, are the best candidates for the construction of polymeric micelles due to their well-reported biocompatibility, availability and cost-effectiveness as well as their abundant functional groups, amenable to chemical modifications [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

et al. 2022

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In this paper, we developed an organic solvent-free, eco-friendly, simple and efficient one-pot approach for the preparation of amphiphilic conjugates (Ugi-OSAOcT) by grafting octylamine (OCA) to oxidized sodium alginate (OSA). The optimum reaction parameters that were obtained based on the degree of substitution (DS) of Ugi-OSAOcT were a reaction time of 12 h, a reaction temperature of 25 °C and a molar ratio of 1:2.4:3:3.3 (OSA:OCA:HAc:TOSMIC), respectively. The chemical structure and composition were characterized by Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (1H NMR), X-ray diffraction (XRD), thermogravimetry analyser (TGA), gel permeation chromatography (GPC) and elemental analysis (EA). It was found that the Ugi-OSAOcT conjugates with a CMC value in the range of 0.30–0.085 mg/mL could self-assemble into stable and spherical micelles with a particle size of 135.7 ± 2.4–196.5 ± 3.8 nm and negative surface potentials of −32.8 ± 0.4–−38.2 ± 0.8 mV. Furthermore, ibuprofen (IBU), which served as a model poorly water-soluble drug, was successfully incorporated into the Ugi-OSAOcT micelles by dialysis method. The drug loading capacity (%DL) and encapsulation efficiency (%EE) of the IBU-loaded Ugi-OSAOcT micelles (IBU/Ugi-OSAOcT = 3:10) reached as much as 10.9 ± 0.4–14.6 ± 0.3% and 40.8 ± 1.6–57.2 ± 1.3%, respectively. The in vitro release study demonstrated that the IBU-loaded micelles had a sustained and pH-responsive drug release behavior. In addition, the DS of the hydrophobic segment on an OSA backbone was demonstrated to have an important effect on IBU loading and drug release behavior. Finally, the in vitro cytotoxicity assay demonstrated that the Ugi-OSAOcT conjugates exhibited no significant cytotoxicity against RAW 264.7 cells up to 1000 µg/mL. Therefore, the amphiphilic Ugi-OSAOcT conjugates synthesized by the green method exhibited great potential to load hydrophobic drugs, acting as a promising nanocarrier capable of responding to pH for sustained release of hydrophobic drugs.

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Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: Breakthroughs and bottlenecks

Cited by 66 publications

References 249 publications

Research progress on self-assembled nanodrug delivery systems

Research progress on self-assembled nanodrug delivery systems

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

One-Pot Synthesis of Amphiphilic Biopolymers from Oxidized Alginate and Self-Assembly as a Carrier for Sustained Release of Hydrophobic Drugs

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