“Harmonization” of donor and recipient tomography in corneal transplantation

Mäurer, Stephanie; Seitz, Berthold; Langenbucher, Achim

doi:10.1016/j.zemedi.2020.05.006

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…All these functionalities run in an integrated and simultaneous sequence after a single imaging, which supports the efficiency of this semi-automated method in comparison to a manual CCT measurement or a single central cross-line scan. In the future, curvature mapping could allow to orient the transplant during the surgery in order to align the steep and flat meridians of donor and recipient together and thus minimize postoperative astigmatism (''harmonization'' of donor and recipient tomography) (Ma ¨urer et al 2021). Until today, this self-programmed MATLAB software was used to analyze raw data from 3DV-files from CASIA or CASIA 2 AS-OCT (Tomey, Nagoya, Japan) and from AVI-files from Spectralis AS-OCT (Heidelberg Engineering, Heidelberg, Germany).…”

Section: Resultsmentioning

confidence: 99%

Reliability and efficiency of corneal thickness measurements using sterile donor tomography in the eye bank

et al. 2021

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To evaluate the reliability and efficiency of sterile pachymetric measurements of donor corneas based on tomographic data using two different methods: a “manual” and a “(semi-)automated” method. Twenty-five (25) donor corneas (50%) stored in MI and 25 (50%) in MII were imaged 5 times consecutively using an anterior segment OCT (AS-OCT). The central corneal thickness (CCT) was measured both with the manual measurement tool of the AS-OCT (= CCTm) and with a MATLAB self-programmed software allowing (semi-)automated analysis (= CCTa). We analyzed the reliability of CCTm and CCTa using Cronbach´s alpha (α) and Wilcoxon signed-Rank Test. Concerning CCTm, 68 measurements (54.4%) in MI and 46 (36.8%) in MII presented distortions in the imaged 3D-volumes and were discarded. Concerning CCTa, 5 (4%) in MI and 1 (0.8%) in MII were not analyzable. The mean (± SD) CCTm was 1129 ± 6.8 in MI and 820 ± 5.1 µm in MII. The mean CCTa was 1149 ± 2.7 and 811 ± 2.4 µm, respectively. Both methods showed a high reliability with a Cronbach´s α for CCTm of 1.0 (MI/MII) and for CCTa of 0.99 (MI) and 1.0 (MII). Nevertheless, the mean SD of the 5 measurements was significantly higher for CCTm compared to CCTa in MI (p = 0.03), but not in MII (p = 0.92). Sterile donor tomography proves to be highly reliable for assessment of CCT with both methods. However, due to frequent distortions regarding the manual method, the (semi-)automated method is more efficient and should be preferred.

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Section: Resultsmentioning

confidence: 99%

Reliability and efficiency of corneal thickness measurements using sterile donor tomography in the eye bank

et al. 2021

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“…The method lasts about 12 minutes -2 minutes for measurement and 10 minutes for evaluation. In the future, sterile donor tomography could enable: (1) the harmonisation of donor and recipient tomography [23,24], poten-tially minimising persistent residual astigmatism after suture removal for a particular donor-recipient pair; and (2) the improvement of the IOL power calculation in a classical triple procedure by means of regression analysis between pre-and postoperative total refractive power of donor corneal tissues [25]. These projects are currently being researched in Homburg/Saar.…”

Section: Discussionmentioning

confidence: 99%

OCT Application for Sterile Corneal Graft Screening in the Eye Bank

Quintin

Hamon

Mäurer

et al. 2021

Klin Monbl Augenheilkd

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Background and Objective Sterile donor tomography enables the detection of corneal tissues with refractive anomalies. The aim of this study was to determine the curvature and thickness of donor corneas to support proper selection in the eye bank. Methods 704 donor corneas (Klaus Faber Center, LIONS Eye Bank Saar-Lor-Lux, Trier/Westpfalz, in Homburg/Saar) were measured using the anterior segment optical coherence tomograph (AS-OCT) CASIA 2 (Tomey Corp., Nagoya, Japan). The corneoscleral discs were measured in their cell culture flask, which was positioned in a holder on the chin rest of the AS-OCT, after conversion to medium II (with 6% dextran T-500). The measured raw data were analysed and processed in MATLAB (MathWorks Inc., Natick, Massachusetts, USA), after which the refractive power of the steep and flat meridian at the anterior and posterior surface and the central corneal thickness (CCT) of the donor corneas were determined. Results values are expressed as mean x̅ ± standard deviation SD. Results The mean refractive power of the steep/flat meridian at the anterior surface was 45.4 ± 1.8 D/44.0 ± 1.3 D, the corresponding values for the posterior surface were − 6.2 ± 0.3 D/− 5.9 ± 0.2 D, and the mean CCT was 616.3 ± 85.1 µm. Of the 704 (100%) measured donor tissues, 590 (83.8%)/670 (95.2%) donor corneas showed no anomaly beyond respectively x̅ ± 2 SD/x̅ ± 3 SD among the 5 examined parameters. 72 (10.3%)/23 (3.3%) donor corneas had only 1 anomaly, 26 (3.7%)/10 (1.4%) had 2 anomalies, 10 (1.4%)/1 (0.1%), 3 anomalies, 5 (0.7%)/0 (0.0%), 4 anomalies, and 1 (0.1%)/0 (0.0%), 5 anomalies. Conclusions AS-OCT provides an objective and sterile screening method to identify corneal tissues with curvature anomalies in order to further optimise donor selection in the eye bank. To avoid postoperative refractive surprises, donor corneas with a total refractive power that deviates > ± 3 SD from the mean should not be used for penetrating or anterior lamellar keratoplasty, but may be suitable for posterior lamellar keratoplasty (DMEK or DSAEK). In the future, sterile donor tomography could enable: (1) the harmonisation of donor and recipient tomography, which may minimise residual astigmatism for a particular donor-recipient pair; and (2) the improvement of IOL power calculation in a classical triple procedure by means of regression analysis between pre- and postoperative total refractive power of corneal grafts.

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“…A trepanação do botão corneano do doador acima de 8mm apresentou associação estatística significativa com a incidência das complicações intraoperatórias, como demonstraram estudos realizados no Brasil e Nova Zelândia. Um estudo alemão apontou que a "harmonização" da aplicabilidade entre tecido doador e receptor foi realizada por meio da medição com o uso da tomografia de coerência óptica do segmento anterior Casia 2, no intuito de reduzir o astigmatismo residual após o transplante corneano (CRUZ et al, 2019;MEYER et al, 2016;MÄURER;SEITZ;LANGENBUCHER, 2020).…”

Section: Característicasunclassified

Análise das características clínicas e dos fatores epidemiológicos e cirúrgicos de transplantados com córneas

Cardoso¹,

Ferreira

Frota

et al. 2022

CONJ

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Objetivo: analisar as características clínicas, os fatores epidemiológicos dos pacientes transplantados com córneas e os procedimentos cirúrgicos realizados. Método: estudo epidemiológico, quantitativo, transversal, descritivo e analítico, cujos dados foram coletados junto ao Banco de Tecido Ocular Humano e Central Estadual de Transplantes, no período de janeiro a junho de 2019. Para a análise estatística utilizou-se o software livre estatístico R, versão 3.0.0, com nível de significância de 5%. Resultados: Foram analisados 823 procedimentos de transplantes de córneas, cuja idade média dos receptores foi de 48,41 anos. O ceratocone constituiu no principal diagnóstico ocular indicativo para o procedimento, com predomínio das cirurgias penetrantes em relação a técnica lamelar. Conclusão: Os transplantes de córneas em MS foram realizados em sua maioria em pacientes do sexo feminino, com idade até 50 anos, residentes na capital do estado. As córneas doadas apresentaram tamanhos maiores do que as dos receptores, sem vascularização ou cirurgia prévia.

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“Harmonization” of donor and recipient tomography in corneal transplantation

Cited by 8 publications

References 9 publications

Reliability and efficiency of corneal thickness measurements using sterile donor tomography in the eye bank

Reliability and efficiency of corneal thickness measurements using sterile donor tomography in the eye bank

OCT Application for Sterile Corneal Graft Screening in the Eye Bank

Análise das características clínicas e dos fatores epidemiológicos e cirúrgicos de transplantados com córneas

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