OCT Application for Sterile Corneal Graft Screening in the Eye Bank

Quintin, Adrien; Hamon, Loïc; Mäurer, Stephanie; Langenbucher, Achim; Seitz, Berthold

doi:10.1055/a-1443-5451

Cited by 11 publications

(11 citation statements)

References 21 publications

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“…16,17 Anterior Segment Optical Coherence Tomography has also been used to detect curvature abnormalities in donor corneas to further optimize donor selection in eye bank. 18 In our study, we found the difference in endothelial cell density in the phakic group (2757.66328.5 cells/mm 2 ) and pseudophakic group (2225.56471.9 cells/mm 2 ) to be statistically significant (P,0.0001), but the difference in coefficient of variation and hexagonality was not significant. In another study, there were no statistically significant differences between the PC-intraocular lens corneas and the controls for any of the three major endothelial parameters (i.e., cell density, percentage of hexagonal cells, and coefficient of variation) studied.…”

Section: Discussionmentioning

confidence: 47%

Comparison of Corneal Tissue Profile of Pseudophakic and Phakic Donors

Sahoo¹,

Jamil²,

Sahu³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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To compare the endothelial quality of corneas obtained from pseudophakic donors with age-matched phakic controls. Methods: Retrospective analysis of 100 corneas each from pseudophakic and phakic eyes with donor age $60 years in both the groups was performed. The endothelial cell density, coefficient of variation, and percentage of hexagonal cells obtained by specular microscopy were compared between the two groups. The cut-off level of endothelial cell density (ECD) taken for optical keratoplasty was 2,000 cells/mm 2 . Results: The male and female donors constituted 60% (n¼120) and 40% (n¼80), respectively. The mean age of the donors was 66.967.3 years in the phakic group and 69.967.7 years in pseudophakic group. The mean ECD in the phakic group was 2757.66328.5 cells/mm 2 and that in the pseudophakic group was 2225.56471.9 cells/mm 2 (P,0.0001). The mean coefficient of variation in the phakic group was 37.165.0 and that in the pseudophakic group was 38.6611.1 (P¼0.234). The mean percentage of hexagonality in the phakic group and the pseudophakic group was 52.066.4% and 51.267.2%, respectively (P¼0.414). Both in univariate and multivariate linear regression analysis, age of the donor was found to be negatively associated in predicting ECD (P¼0.002 and P¼0.003, respectively). Sixty-nine and thirty-three corneas from the phakic and pseudophakic donor pool were used respectively. Conclusion: Difference in ECD between the phakic and the pseudophakic donor group was found to be statistically significant. The ECD in the pseudophakic group was found to be above the cut-off limit required for keratoplasty. Hence, pseudophakic corneas may also be used for transplantation.

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Section: Discussionmentioning

confidence: 47%

Comparison of Corneal Tissue Profile of Pseudophakic and Phakic Donors

Sahoo¹,

Jamil²,

Sahu³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Donor corneas that are suitable for a transplantation are preoperatively examined for possible pathologies and anomalies using the inverted light microscopy and the optical coherence tomography (Quintin et al. 2021). As per our in‐house eye bank quality management protocol, the first step, is an examination of the cornea using a slit lamp microscope.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and severity of cornea guttata in the graft following Descemet Membrane Endothelial Keratoplasty (DMEK)

Schmitz

Safi

Munteanu

et al. 2022

Acta Ophthalmologica

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Purpose: The aim of this study was to determine the prevalence and severity of cornea guttata (CG) in grafts after Descemet membrane endothelial keratoplasty (DMEK) and to investigate its impact on various clinical parameters during follow-up. Methods: This retrospective study included 664 operations (DMEK and triple-DMEK) on 466 patients. The prevalence and progression of CG after the operation were examined using endothelial specular microscopy images. The severity grade of CG was classified into four grades: G0 without CG, G1 -G3 with increasing severity of CG. Clinical parameters such as central corneal thickness (CCT), visual acuity (VA), endothelial cell density (ECD), pleomorphism and polymegalism were examined during a postoperative follow-up time of 19.6 AE 15.8 months. Results: Cornea guttata (CG) appeared postoperatively in 124 (18.7%) eyes. 112 (16.9%) could be classified as G1, 9 (1.4%) as G2 and only 3 (0.5%) as G3. The examination of clinical parameters showed significant differences between healthy and low-grade CG (G0/G1) and high-grade CG (G2/G3). A significant deterioration was found in the corrected distance visual acuity (CDVA) (p = 0.02). CCT showed an increase between G0 (534 AE 58 lm) and G2 (549 AE 71 lm)/G3 (558 AE 56 lm) with a p-value of 0.02. Additionally, a significant increase in pleomorphism (p = 0.003) and polymegalism (p = 0.04) was detected. Conclusion: Cornea guttata (CG) prevalence after DMEK and triple-DMEK was found to be 18.7%, although most of these cases were classified as low-grade CG and showed no clinical significance. Around 1.9% were classified as high-grade CG and significantly affected several clinical parameters during the follow-up.

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“…Another report from Germany has also found that the implementation of a quality management system and better management of contamination significantly reduces the rate of discarded donor tissue in the eye bank (27). Moreover, technical improvements, such as the application of anterior segment optical coherence tomograph providing a sterile screening method to identify corneal tissues, have further optimized donor selection and increased the utilization rate (28). Cornea arcus senilis was one of the causes of poor corneal quality as well as corneas with an endothelial cell count below 2,000 per mm 2 .…”

Section: Discussionmentioning

confidence: 99%

Trends in Corneal Transplantation and Characteristics of Donors in the Chongqing Eye Bank, China: A Retrospective Study, 1999–2018

et al. 2021

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Aim: This study aimed to analyze corneal transplantation trends and voluntary donor characteristics at the Chongqing Eye Bank in China.Methods: We retrospectively reviewed and analyzed data from January 1, 1999, to December 31, 2018, covering 5,397 preregistered voluntary donors, 1,955 actual donors, 3,910 donated tissues, and 2,374 corneal transplantations.Results: The 5,397 preregistered donors included 13 ethnic groups, with an overall mean age of 39.6 years (SD 21.5) and 3,010 were women (55.8%). The most prevalent education level was college and above (2,546, 47.2%), and the most common ethnic group was Han (5,335, 98.85%). Of the 1,955 actual donors, the male-to-female ratio was 3.3, and the mean age was 57.1 (SD 23.0 years). Based on population size in 2018, Jiangbei county was the most active in donation willingness, with ~60 × 10−6 per capita, and the Yuzhong county was the most active in cornea donations, with ~451 × 0−6 per capita. Of the 3,910 donated corneas, 2,540 (65.0%) were clinically used. Of those not used, 978 (71.4%) were rejected for poor corneal quality. The 2,374 (93.5%) corneal transplantation procedures were done at the Department of Ophthalmology of the First Affiliated Hospital of Chongqing Medical University and the rest (n = 166, 6.5%) were performed in other centers. Of those 2,374 corneal transplantations, there were 1,671 penetrating keratoplasty (70.39%), 700 anterior lamellar keratoplasty (29.49%), and three corneal endothelial transplantations in our center (0.13%). The number of annual corneal transplantations increased by nearly 10 times, from 35 cases in 1999 to 327 cases in 2018. Among them, cases of penetrating keratoplasty and anterior lamellar keratoplasty increased from 27, and eight cases in 1999 to 230 and 94 cases in 2018, respectively. Infectious keratitis (37.0%) was the leading indication for keratoplasty, followed by corneal scar (19.8%). Over the study period, corneal scars dropped from the first (41.1% in 1999–2003) to the second indication (20.5% in 2014–2018), while infectious keratitis advanced to take the lead, ranging from 12.2% in 1999–2003 to 26.3% in 2014–2018.Conclusion: Our study reports corneal donation and transplantation trends in Chongqing over 20 years, showing that infectious keratitis is a leading indication for keratoplasty and that penetrating keratoplasty and anterior lamellar keratoplasty show upward trends. The analysis further suggests that a potential preregistered cornea donor is a female Han, with a higher education level.

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OCT Application for Sterile Corneal Graft Screening in the Eye Bank

Cited by 11 publications

References 21 publications

Comparison of Corneal Tissue Profile of Pseudophakic and Phakic Donors

Comparison of Corneal Tissue Profile of Pseudophakic and Phakic Donors

Prevalence and severity of cornea guttata in the graft following Descemet Membrane Endothelial Keratoplasty (DMEK)

Trends in Corneal Transplantation and Characteristics of Donors in the Chongqing Eye Bank, China: A Retrospective Study, 1999–2018

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