Harmonic impedance spectra identification from time-varying bioimpedance: theory and validation

Sanchez, Benjamin; Louarroudi, Ebrahim; Bardia, Ramon Bragós; Pintelon, R.

doi:10.1088/0967-3334/34/10/1217

Cited by 27 publications

(32 citation statements)

References 29 publications

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“…In fact, we initially also identified a similar finding. However, a close look at our data revealed that this perception was due to the temporal window T w needed to discretize data to compute the impedance frequency response using the short time Fourier transform (STFT) [16]. To further prove this, we show Figure 9.…”

Section: Discussionmentioning

confidence: 83%

“…The muscle impedance was measured using a custom broadband impedance frequency response analyzer (FRA) [12], [15], [16]. The impedance measurement system was implemented on a rugged PC-platform PXI (PCI eXtensions for Instrumentation) platform from National Instruments.…”

Section: E Impedance Measurementmentioning

confidence: 99%

“…A consistent impedance spectrum estimator Z (ω k ) (when P → ∞) is obtained from the division of the voltage-current sample mean Fourier coefficients at the excited frequencies [16], namely…”

Section: F Data Acquisition and Analysismentioning

confidence: 99%

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Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Sanchez

Geisbush

et al. 2016

IEEE Trans. Biomed. Eng.

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Abstract-Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work in this field has relied upon the measurement of muscle at rest. To provide insight into the contractile mechanisms of healthy and disease muscle, we evaluated the alterations in the spectroscopic impedance behavior of muscle during the active process of muscle contraction. The gastrocnemii from a total of 13 mice were studied (5 wild type, 4 muscular dystrophy animals, and 4 amyotrophic lateral sclerosis animals). Muscle contraction was induced via monophasic current pulse stimulation of the sciatic nerve. Simultaneously, multisine EIM (1 kHz to 1 MHz) and force measurements of the muscle were performed. Stimulation was applied at 3 different rates to produce mild, moderate and strong contractions. We identified changes in both single and multifrequency data, as assessed by the Cole impedance model parameters. The processes of contraction and relaxation were clearly identified in the impedance spectra and quantified via derivative plots. Reductions in the center frequency f c were observed during the contraction consistent with increasing muscle fiber diameter. Different EIM stimulation rate-dependencies were also detected across the 3 groups of animals.

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Section: Discussionmentioning

confidence: 83%

Section: E Impedance Measurementmentioning

confidence: 99%

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Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Sanchez

Geisbush

et al. 2016

IEEE Trans. Biomed. Eng.

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“…The impedance was calculated on the basis of the division of the output-input Fast Fourier Transform (FFT) coefficients at the excited frequencies [38]. Once the impedance was calculated, noise reduction was performed with a moving average filter (length n=10) independently for each 860 ms continuous measurement segment.…”

Section: Data Pre-processingmentioning

confidence: 99%

Interpulse multifrequency electrical impedance measurements during electroporation of adherent differentiated myotubes

García-Sánchez

Azan

Leray

et al. 2015

Bioelectrochemistry

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In this study, electrical impedance spectroscopy measurements are performed during electroporation of monolayers of differentiated myotubes. The time resolution of the system (1 spectrum/ms) enable 860 full spectra (21 frequencies from 5 kHz to 1.3 MHz) to be acquired during the time gap between consecutive pulses (interpulse) of a classical electroporation treatment (8 pulses, 100 µs, 1 Hz). Additionally, the characteristics of the custom microelectrode assembly used allow the experiments to be performed directly in situ in standard 24 multi-well plates. The impedance response dynamics are studied for three different electric field intensities (400, 800 and 1200 V/cm).The multifrequency information, analysed with the Cole model, reveals a short-term impedance recovery after each pulse in accordance with the fast resealing of the cell membrane, and a longterm impedance decay over the complete treatment in accordance with an accumulated effect pulse after pulse. The analysis shows differences between the lowest electric field condition and the other two, suggesting that different mechanisms that may be related with the reversibility of the process are activated. As a result of the multifrequency information, the system is able to measure simultaneously the conductivity variations due to ion diffusion during electroporation.Finally, in order to reinforce the physical interpretation of the results, a complementary electrical equivalent model is used.

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“…based on multisines signals [10], [11], [12]. Using the multifrequency approach, many frequencies are applied simultaneously (B) and the time to acquire a complete EIM spectrum is drastically reduced making it possible to measure the instantaneous impedance changes and temporal evolution of dynamic EIM, for example, during muscle contraction and relaxation and to collect both nonand fatigued muscle data.…”

Section: Impedance Instrumentationmentioning

confidence: 99%

A pilot spectroscopy study on time-varying bioimpedance during electrically-induced muscle contraction

Sanchez

Geisbush

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work has relied upon single-frequency/spectroscopy stepped-sine measurements of static muscle (contracted or relaxed). In this work, we assessed the temporal alterations in the impedance spectrum (1 kHz to 1 MHz) behavior of gastrocnemius during the active process of muscle contraction. The approach is based on the multisine impedance spectroscopy technique. The gastrocnemii of a wild type mouse was measured during electrically-induced muscle contraction via direct current stimulation of the sciatic nerve. The processes of contraction and relaxation were clearly identified in the time-frequency impedance spectrum likely corresponding to an increase muscle fiber diameter. The technique of dynamic multisine EIM has the potential of providing useful insights into contractile mechanisms of muscle in health and disease.

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Harmonic impedance spectra identification from time-varying bioimpedance: theory and validation

Cited by 27 publications

References 29 publications

Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Impedance Alterations in Healthy and Diseased Mice During Electrically Induced Muscle Contraction

Interpulse multifrequency electrical impedance measurements during electroporation of adherent differentiated myotubes

A pilot spectroscopy study on time-varying bioimpedance during electrically-induced muscle contraction

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