A pilot spectroscopy study on time-varying bioimpedance during electrically-induced muscle contraction

Abstract

Alterations in the health of muscles can be evaluated through the use of electrical impedance myography (EIM). To date, however, nearly all work has relied upon single-frequency/spectroscopy stepped-sine measurements of static muscle (contracted or relaxed). In this work, we assessed the temporal alterations in the impedance spectrum (1 kHz to 1 MHz) behavior of gastrocnemius during the active process of muscle contraction. The approach is based on the multisine impedance spectroscopy technique. The gastrocnemii of a wild type mouse was measured during electrically-induced muscle contraction via direct current stimulation of the sciatic nerve. The processes of contraction and relaxation were clearly identified in the time-frequency impedance spectrum likely corresponding to an increase muscle fiber diameter. The technique of dynamic multisine EIM has the potential of providing useful insights into contractile mechanisms of muscle in health and disease.

Time-domain Multitone Impedance Measurement System for Space Applications

“…On the other hand, in [6], a novel measurement approach based on the wideband excitation is presented for a high-speed railway application. Moreover, multitone excitation methods have been used for bioimpedance applications [7].…”

Near‐binary multisine design with arbitrary sparse spectrum for fast BIS measurement

“…Sanchez et al showed that only 20 ms is needed to perform an online broadband BIS measurement from 1 kHz to 1 MHz with 26 quasi-log frequencies [6]. The fast BIS technology can be used for grasping the transient physiological status of the living body such as in myocardial system [7], the respiratory system [8] or muscle contraction [9].…”