Harmonic and frequency modulated ultrasonic vocalizations reveal differences in conditioned and unconditioned reward processing

Garcia, Erik J.; McCowan, Talus J; Cain, Mary E.

doi:10.1016/j.bbr.2015.03.049

Cited by 14 publications

(17 citation statements)

References 47 publications

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“…Our previous research shows that anticipatory USVs change differently in the context associated with natural reward (experimenter-induced tickling), and with actually receiving natural rewards [10]. The present study aimed to determine if voluntary ETOH drinking changes the IEN and USV responses differently.…”

Section: Introductionmentioning

confidence: 89%

“…Analysis of each sound file was done using AviSoft SASLab Pro Bioacoustics sound analysis software. Potential USVs of all call types and frequencies were counted automatically and manually scored by a trained researcher similar to previous literature [10,20,41,42]. Briefly, a spectrogram was created for each rat that displayed all sounds recorded in the possible 1–100 kHz sound range.…”

Section: Methodsmentioning

confidence: 99%

“…The inescapable novelty test was first followed by the heterospecific test (experimenter tickling to mimic juvenile play). The order was determined on level of intrusiveness, and by previous research [9,10,20]. A schematic of the experimental procedures outlines the timeline of events (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…We compared responses before the drink phase to post drink period test responses. Our lab has recently published that in Sprague-Dawley rats different types of USVs reveal differences in reward processing [10]. Therefore, another aim of this study was to determine whether conditioned and unconditioned reward processing changed differently in Long-Evans rats after ETOH exposure.…”

Section: Methodsmentioning

confidence: 99%

“…Fifty kHz USVs are emitted in response to appetitive stimuli and are indicative of positive affect [23–27]. Trill and frequency modulated (FM) USVs are types of 50 kHz USV that is highly correlated with reward [10,23,28–31]. Twenty-two kHz USVs are emitted when presented with aversive stimuli, during drug withdrawal, and are indicative of negative affect [32–35].…”

Section: Introductionmentioning

confidence: 99%

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Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

Garcia¹,

Jorgensen²,

Sprick³

et al. 2017

Behavioural Brain Research

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Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation—measured by ultrasonic vocalizations (USVs)—change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test. Then rats were tested for their affective response to a natural reward and USVs were measured. The natural reward was experimenter-induced play behavior. Rats were exposed to ETOH for 8 weeks using an intermittent two bottle paradigm. After 8 weeks of voluntary consumption, rats were retested for their response to NSS and affective response to natural reward. Results indicate that voluntary ETOH consumption did not change the response to novelty. Control and ETOH exposed rats decreased their novelty response equally after ETOH consumption, suggesting the decrease was due to age. Importantly, voluntary ETOH consumption changed affective USVs. Compared to water-drinking control rats, ETOH-consuming rats elicited greater anticipatory trill USVs to a natural reward-associated context during a post-drinking probe test. Tickle-induced trill USVs did not change differently between ETOH and control rats. These results provide evidence that voluntary intermittent ETOH exposure increases the anticipation of reward and may represent a form of incentive salience. We postulate these diverging effects could be due to differences in incentive salience or reward processing. Together, these results suggest that voluntary ETOH consumption changes the affective response to conditioned and unconditioned natural rewards and offers a behavioral mechanism for studying affective reward processing after ETOH consumption.

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Section: Introductionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

Garcia¹,

Jorgensen²,

Sprick³

et al. 2017

Behavioural Brain Research

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Novelty response and 50 kHz ultrasonic vocalizations: Differential prediction of locomotor and affective response to amphetamine in Sprague-Dawley rats

Garcia

Cain

2015

Psychopharmacology

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Rationale Novelty and sensation seeking (NSS) predisposes humans and rats to experiment with psychostimulants. In animal models, different tests of NSS predict different phases of drug dependence. Ultrasonic vocalizations (USV) are evoked by psychomotor stimulants and measure the affective/motivation response to stimuli, yet the role NSS has on USV in response to amphetamine is not determined. Objectives Determine if individual differences in NSS and USV can predict locomotor and USV response to amphetamine (0.3, and 1.0 mg/kg) at different exposure lengths. Methods Thirty male rats were tested for their response to novelty (IEN), choice to engage in novelty (NPP), and heterospecific play (H-USV). Rats were administered non-contingent amphetamine or saline for 7 exposures and USV and locomotor activity were measured. After a 14-day rest, rats were administered a challenge dose of amphetamine. Results Regression analyses indicated that amphetamine dose-dependently increased locomotor activity and the NPP test negatively predicted treatment-induced locomotor activity. The H-USV test predicted treatment-induced frequency modulated (FM) USV, but the strength of prediction depended on IEN response. Conclusions Results provide evidence that locomotor activity and FM USV induced by amphetamine represent different behavioral responses. The prediction of amphetamine-induced FM USV by the H-USV screen was changed by the novelty response, indicating that the affective value of amphetamine—measured by FM USV—depends on novelty response. This provides evidence that higher novelty responders may develop a tolerance faster and may escalate intake faster.

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Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations

2017

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Harmonic and frequency modulated ultrasonic vocalizations reveal differences in conditioned and unconditioned reward processing

Cited by 14 publications

References 47 publications

Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

Novelty response and 50 kHz ultrasonic vocalizations: Differential prediction of locomotor and affective response to amphetamine in Sprague-Dawley rats

Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations

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