Harmine enhances GABAergic transmission onto basoamygdala projection neurons in mice

Liu, Wei-Zhu; Huang, Bowei; You, Wen-Jie; Hu, Ping; Wang, Xuehui; Zhang, Junyu; Xü, Xinsheng; Zhang, Zongyong; Pan, Bing‐Xing; Zhang, Wenhua

doi:10.1016/j.brainresbull.2018.01.004

Cited by 19 publications

(11 citation statements)

References 35 publications

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“…Amygdala slices were prepared as previously described [20]. Briefly, the mice were anesthetized with ether and decapitated, then brains were quickly removed from the skull and chilled in ice-cold artificial cerebrospinal fluid (ACSF) containing (in mM) 124 NaCl, 2.5 KCl, 2 MgSO 4 , 2.5 CaCl 2 , 1.25 NaH 2 PO 4 , 22 NaHCO 3 , and 10 glucose, gassed with 95% O 2 and 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice

Qin

Wang

et al. 2019

Mol Brain

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Exposure to moderate level of stress during the perinatal period helps the organisms to cope well with stressful events in their later life, an effect known as stress inoculation. Amygdala is one of the kernel brain regions mediating stress-coping in the brain. However, little is known about whether early life stress may affect amygdala to have its inoculative effect. Here, we observed that moderate maternal separation (MS) from postnatal day 3 to day 21 (D3–21, 1 h per day) significantly alleviated the increased anxiety-like behavior induced by chronic social defeat stress (CSDS) in adulthood, suggesting an obvious inoculative effect of moderate MS. Further studies revealed that MS prevented CSDS-evoked augmentation of glutamatergic transmission onto principal neurons (PNs) in the basolateral amygdala (BLA) by inhibiting presynaptic glutamate release. By contrast, it did not affect GABAergic transmission in BLA PNs, as indicated by unaltered frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). Moreover, the CSDS-induced increase of neuronal excitability was also mitigated by MS in BLA PNs. In conclusion, our results suggest that MS may have its inoculative effect through alleviating the influences of later life stress on the glutamatergic transmission and neuronal activity in amygdala neurons.

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Section: Methodsmentioning

confidence: 99%

Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice

Qin

Wang

et al. 2019

Mol Brain

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“…Stress induced persistent anxiety via the extra-amygdala septohypothalamic circuit ( Anthony et al, 2014 ). Liu et al (2018) found that harmine potentiates the GABAergic transmission onto BLA projection neurons. However, only partially understood about the role of neuronal components of these regions in amygdala circuits.…”

Section: Influence Of the Gabaergic System In Amygdala Responses To Smentioning

confidence: 99%

Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases

et al. 2018

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The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.

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“…[10] Harmine and harmaline are the most important alkaloids available in P. harmala that have positive effects. [11] The essence of this plant can be used to treat bradycardia, decrease blood pressure, control angiogenesis, and has antiallergic, antispasm, and antiadrenergic effects. [12] Traditional medicine has listed its positive effects as being a soporific emmenagogue, appetite inducer, and antiparasitic.…”

Section: Introductionmentioning

confidence: 99%

Effect of harmine on nicotine-induced kidney dysfunction in male mice

et al. 2019

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Background: The nicotine content of cigarettes plays a key role in the pathogenesis of kidney disease. Harmine is a harmal-derived alkaloid with antioxidant properties. This study was designed to evaluate the effects of harmine against nicotine-induced damage to the kidneys of mice. Methods: In this study, 64 male mice were randomly assigned to eight groups: saline and nicotine-treated groups (2.5 mg/kg), harmine groups (5, 10, and 15 mg/kg), and nicotine (2.5 mg/kg) + harmine-treated groups (5, 10, and 15 mg/kg). Treatments were administered intraperitoneally daily for 28 days. The weights of the mice and their kidneys, kidney index, glomeruli characteristics, thiobarbituric acid reactive species, antioxidant capacity, kidney function indicators, and serum nitrite oxide levels were investigated. Results: Nicotine administration significantly improved kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased glomeruli number and tissue ferric reducing/antioxidant power (FRAP) level compared to the saline group ( P < 0.05). The harmine and harmine + nicotine treatments at all doses significantly reduced BUN, kidney MDA level, creatinine, glomerular diameter, and nitrite oxide levels and increased the glomeruli number and tissue FRAP level compared to the nicotine group ( P < 0.05). Conclusions: It seems that harmine administration improved kidney injury induced by nicotine in mice.

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Harmine enhances GABAergic transmission onto basoamygdala projection neurons in mice

Cited by 19 publications

References 35 publications

Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice

Moderate maternal separation mitigates the altered synaptic transmission and neuronal activation in amygdala by chronic stress in adult mice

Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases

Effect of harmine on nicotine-induced kidney dysfunction in male mice

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