Harmful or harmless: Biological effects of marennine on marine organisms

Falaise, Charlotte; Tremblay, Réjean; Audet, Céline; Deschênes, Jean-Daniel; Turcotte, François; François, Cyrille; Seger, Andreas; Hallegraeff, Gustaaf M.; Lindquist, Niels; Sirjacobs, Damien; Gobert, Sylvie; Lejeune, Pierre; Demoulin, V.; Mouget, Jean‐Luc

doi:10.1016/j.aquatox.2019.01.016

Cited by 11 publications

(7 citation statements)

References 46 publications

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“…However, previous studies conducted with purified extracellular marennine (EMn) on marine bacteria, including Vibrio species, confirmed that the pigment itself did exert an antibacterial activity [9,10,11,12]. Moreover, a recent study has demonstrated the biological activities of marennine solutions, including BW and EMn, on the development or survival of various marine organisms, and comparable effects were observed between the different solutions tested [21]. Also, if blue Haslea species should be cultured at large scale to ensure the production of marennine solutions for applications as antimicrobials in aquaculture, BW represents the easiest and cheapest production process, compared to the purified pigment.…”

Section: Discussionmentioning

confidence: 99%

Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

et al. 2019

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Marennine, the water-soluble blue pigment produced by the marine diatom Haslea ostrearia, is known to display antibacterial activities. Previous studies have demonstrated a prophylactic effect of marennine on bivalve larvae challenged with a pathogenic Vibrio splendidus, suggesting that the blue Haslea is a good candidate for applications in aquaculture as a source of a natural antimicrobial agent. Indeed, the genus Vibrio is ubiquitous in aquaculture ecosystems, and regular events of pathogenic invasion cause some of the biggest losses worldwide. To better characterize the effects of marennine on Vibrios, a panel of 30 Vibrio strains belonging to 10 different species was tested, including bivalve pathogenic species (e.g., Vibrio crassostreae and Vibrio harveyi). Vibrio strains were first exposed to 10 and 25 µg mL−1 of Blue Water (BW), a concentrated culture supernatant of H. ostrearia containing marennine. This screening evidenced a great diversity in responses, from growth stimulation to a total inhibition, at both the interspecific or intraspecific level. In a second series of experiments, 10 Vibrio strains were exposed to BW at concentrations ranging from 5 to 80 µg mL−1. The highest concentrations of BW did not systematically result in the highest growth inhibition as hormetic responses—opposite effects regarding the concentration—were occasionally evidenced. The relationships between marennine and Vibrio strains appear more complex than expected and justify further study—in particular, on the mechanisms of action—before considering applications as a natural prophylactic or antibiotic agent in aquaculture.

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Section: Discussionmentioning

confidence: 99%

Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

et al. 2019

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“…Marennine is responsible for the greening of oyster gills in Western Europe [4][5][6][7]. Marennine and marennine-like pigments also display several biological activities (e.g., antibacterial, antiviral, or antioxidant) qualifying them for putative use in aquaculture and biotechnology [8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Haslea silbo, A Novel Cosmopolitan Species of Blue Diatoms

Gastineau

Hansen

Poulin

et al. 2021

Biology

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Specimens of a new species of blue diatoms from the genus Haslea Simonsen were discovered in geographically distant sampling sites, first in the Canary Archipelago, then North Carolina, Gulf of Naples, the Croatian South Adriatic Sea, and Turkish coast of the Eastern Mediterranean Sea. An exhaustive characterization of these specimens, using a combined morphological and genomic approach led to the conclusion that they belong to a single new to science cosmopolitan species, Haslea silbo sp. nov. A preliminary characterization of its blue pigment shows similarities to marennine produced by Haslea ostrearia, as evidenced by UV–visible spectrophotometry and Raman spectrometry. Life cycle stages including auxosporulation were also observed, providing data on the cardinal points of this species. For the two most geographically distant populations (North Carolina and East Mediterranean), complete mitochondrial and plastid genomes were sequenced. The mitogenomes of both strains share a rare atp6 pseudogene, but the number, nature, and positions of the group II introns inside its cox1 gene differ between the two populations. There are also two pairs of genes fused in single ORFs. The plastid genomes are characterized by large regions of recombination with plasmid DNA, which are in both cases located between the ycf35 and psbA genes, but whose content differs between the strains. The two sequenced strains hosts three plasmids coding for putative serine recombinase protein whose sequences are compared, and four out of six of these plasmids were highly conserved.

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“…The name “marennine” was proposed by Lankester [ 19 ] in reference to Marennes-Oléron (Marennes, 45°49′25.8″ N 1°06′16.3″ W), a region of western France where oysters have been farmed for centuries. This pigment is responsible for the greening of oyster gills, a natural phenomenon of great importance for the oyster industry [ 20 ]. Haslea ostrearia is not only present on the French Brittany coasts but also within the Pacific Ocean on the Australian, American and Japanese coasts [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

Méresse

Gâteau

Tirnan

et al. 2023

IJMS

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Haslea ostrearia, a cosmopolitan marine pennate diatom, produces a characteristic blue pigment called marennine that causes the greening of filter-feeding organisms, such as oysters. Previous studies evidenced various biological activities of purified marennine extract, such as antibacterial, antioxidant and antiproliferative effects. These effects could be beneficial to human health. However, the specific biological activity of marennine remains to be characterized, especially regarding primary cultures of mammals. In the present study, we aimed to determine in vitro the effects of a purified extract of marennine on neuroinflammatory and cell migratory processes. These effects were assessed at non-cytotoxic concentrations of 10 and 50μg/mL on primary cultures of neuroglial cells. Marennine strongly interacts with neuroinflammatory processes in the immunocompetent cells of the central nervous system, represented by astrocytes and microglial cells. An anti-migratory activity based on a neurospheres migration assay has also been observed. These results encourage further study of Haslea blue pigment effects, particularly the identification of molecular and cellular targets affected by marennine, and strengthen previous studies suggesting that marennine has bioactivities which could be beneficial for human health applications.

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Harmful or harmless: Biological effects of marennine on marine organisms

Cited by 11 publications

References 46 publications

Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

Haslea silbo, A Novel Cosmopolitan Species of Blue Diatoms

Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

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