Harmful Impact of Tobacco Smoking and Alcohol Consumption on the Atrial Myocardium

Ohlrogge, A; Frost, Lars; Schnabel, Renate B.

doi:10.3390/cells11162576

Cited by 8 publications

(5 citation statements)

References 255 publications

(269 reference statements)

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“…However, recent studies suggest that no level of alcohol consumption is safe in humans. These studies show that even moderate alcohol consumption has been associated with ROS generation, hypertension, stroke, vascular alterations in the peripheral and central nervous systems, cognitive decline, and more (Gill et al, 1986;Roerecke et al, 2017;Cho et al, 2022;Ohlrogge et al, 2022;Topiwala et al, 2022).…”

Section: Toxinsmentioning

confidence: 83%

Vascular smooth muscle cell dysfunction in neurodegeneration

Hayes

Pinto²,

Sparks³

et al. 2022

Front. Neurosci.

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Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is compromised. An increasing body of research suggests that VSMCs have remarkable plasticity and their pathophysiology may play a key role in the complex process of neurodegeneration. Furthermore, extrinsic risk factors, including environmental conditions and traumatic events can impact vascular function through changes in VSMC morphology. VSMC dysfunction can be characterised at the molecular level both preclinically, and clinically ex vivo. However the identification of VSMC dysfunction in living individuals is important to understand changes in vascular function at the onset and progression of neurological disorders such as dementia, Alzheimer’s disease, and Parkinson’s disease. A promising technique to identify changes in the state of cerebral smooth muscle is cerebrovascular reactivity (CVR) which reflects the intrinsic dynamic response of blood vessels in the brain to vasoactive stimuli in order to modulate regional cerebral blood flow (CBF). In this work, we review the role of VSMCs in the most common neurodegenerative disorders and identify physiological systems that may contribute to VSMC dysfunction. The evidence collected here identifies VSMC dysfunction as a strong candidate for novel therapeutics to combat the development and progression of neurodegeneration, and highlights the need for more research on the role of VSMCs and cerebrovascular dynamics in healthy and diseased states.

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Section: Toxinsmentioning

confidence: 83%

Vascular smooth muscle cell dysfunction in neurodegeneration

Hayes

Pinto²,

Sparks³

et al. 2022

Front. Neurosci.

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“…In high-middle SDI and above regions, such as Southern Latin America and Australasia, alcohol consumption is particularly prevalent, which could be associated with local cultural customs. Alcohol can cause myocardial fibroplasia and exacerbate myocardial hypertrophy [ 43 ],; therefore implementing certain alcohol interventions can potentially reduce the disease burden caused by hypertension or HHD [ 44 ]. Interestingly, low temperature is suggested to be a risk factor for HHD, with an increase in death and DALYs associated with cold-related HHD in middle and high SDI countries, possibly related to economic development.…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burdens of hypertensive heart disease from 1990 to 2019 ：A multilevel analysis based on the global burden of Disease Study 2019

Hu,

Shi,

Zhang

et al. 2023

Heliyon

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“…In other words, chronic stress can trigger problems with the blockage or rupture of blood vessels in the brain (stroke). Smoking also has a very close relationship with the risk of stroke [38]. This habit can increase the risk of stroke by up to two times by raising blood pressure and reducing oxygen in the blood.…”

Section: Resultsmentioning

confidence: 99%

“…Because when someone smokes, the chemicals in cigarettes (carbon monoxide, formaldehyde, arsenic, and cyanide) enter the lungs and are transferred into the bloodstream [39]. Blood containing these chemicals then flows throughout the body, changing and damaging its cells and affecting how people's bodies work [38]. These changes can then increase the risk of stroke.…”

Section: Resultsmentioning

confidence: 99%

Electronic Medical Record Data Analysis and Prediction of Stroke Disease Using Explainable Artificial Intelligence (XAI)

Pamungkas

Wibawa

Cahya

2022

KINETIK

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The deficiency of oxygen in the brain will cause the cells to die, and the body parts controlled by the brain cells will become dysfunctional. Damage or rupture of blood vessels in the brain is better known as a stroke. Many factors affect stroke. These factors certainly need to be observed and alerted to prevent the high number of stroke sufferers. Therefore, this study aims to analyze the variables that influence stroke in medical records using statistical analysis (correlation) and stroke prediction using the XAI algorithm. Factors analyzed included gender, age, hypertension, heart disease, marital status, residence type, occupation, glucose level, BMI, and smoking. Based on the study results, we found that women have a higher risk of stroke than men, and even people who do not have hypertension and heart disease (hypertension and heart disease are not detected early) still have a high risk of stroke. Married people also have a higher risk of stroke than unmarried people. In addition, bad habits such as smoking, working with very intense thoughts and activities, and the type of living environment that is not conducive can also trigger a stroke. Increasing age, BMI, and glucose levels certainly affect a person's stroke risk. We have also succeeded in predicting stroke using the EMR data with high accuracy, sensitivity, and precision. Based on the performance matrix, PNN has the highest accuracy, sensitivity, and F-measure levels of 95%, 100%, and 97% compared to other algorithms, such as RF, NB, SVM, and KNN.

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Harmful Impact of Tobacco Smoking and Alcohol Consumption on the Atrial Myocardium

Cited by 8 publications

References 255 publications

Vascular smooth muscle cell dysfunction in neurodegeneration

Vascular smooth muscle cell dysfunction in neurodegeneration

Global, regional, and national burdens of hypertensive heart disease from 1990 to 2019 ：A multilevel analysis based on the global burden of Disease Study 2019

Electronic Medical Record Data Analysis and Prediction of Stroke Disease Using Explainable Artificial Intelligence (XAI)

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