Harmful effect of neoadjuvant chemotherapy monitoring by DSC on breast cancer patients’ blood plasma

Ferencz, A.; Zapf, István; Lőrinczy, D.

doi:10.1007/s10973-016-5291-3

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…Several studies suggest that DSC curves can be used to evaluate the efficacy of anti-cancer treatment. DSC curves of serum from recovering breast cancer patients were found to be useful in the prediction of tumor relapse [ 28 ], whereas a preliminary study performed on 11 metastatic LC patients found that DSC curves of serum specimens predicted the response of patients to platinum-based chemotherapy [ 25 ]. Unfortunately, since our study consisted of specimens collected from patients that were either treatment naïve or 30 days after the last dose of chemotherapy, we were unable to verify these observations in our cohort.…”

Section: Discussionmentioning

confidence: 99%

The Utility of Differential Scanning Calorimetry Curves of Blood Plasma for Diagnosis, Subtype Differentiation and Predicted Survival in Lung Cancer

Schneider

Kaliappan

Nguyen

et al. 2021

Cancers

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Early detection of lung cancer (LC) significantly increases the likelihood of successful treatment and improves LC survival rates. Currently, screening (mainly low-dose CT scans) is recommended for individuals at high risk. However, the recent increase in the number of LC cases unrelated to the well-known risk factors, and the high false-positive rate of low-dose CT, indicate a need to develop new, non-invasive methods for LC detection. Therefore, we evaluated the use of differential scanning calorimetry (DSC) for LC patients’ diagnosis and predicted survival. Additionally, by applying mass spectrometry, we investigated whether changes in O- and N-glycosylation of plasma proteins could be an underlying mechanism responsible for observed differences in DSC curves of LC and control subjects. Our results indicate selected DSC curve features could be useful for differentiation of LC patients from controls with some capable of distinction between subtypes and stages of LC. DSC curve features also correlate with LC patients’ overall/progression free survival. Moreover, the development of classification models combining patients’ DSC curves with selected plasma protein glycosylation levels that changed in the presence of LC could improve the sensitivity and specificity of the detection of LC. With further optimization and development of the classification method, DSC could provide an accurate, non-invasive, radiation-free strategy for LC screening and diagnosis.

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Section: Discussionmentioning

confidence: 99%

The Utility of Differential Scanning Calorimetry Curves of Blood Plasma for Diagnosis, Subtype Differentiation and Predicted Survival in Lung Cancer

Schneider

Kaliappan

Nguyen

et al. 2021

Cancers

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show abstract

“…Among recently introduced methods for diagnostics and monitoring of diseases, the differential scanning calorimetry (DSC) seems to be the most promising one, regarding serum protein-based diagnosis 7 – 21 . DSC serum profile shows the heat capacity changes corresponding to the process of proteins unfolding as a function of a temperature.…”

Section: Introductionmentioning

confidence: 99%

“…DSC was tested to show the effects on blood serum caused by different injurious factors that are unavoidable in particular cases, e.g. necessary for treatment (chemotherapy, oxidative stress or neutron radiation) 18 – 21 . For instance, Ferencz et al 21 showed that serum proteins denaturation profile of recovering breast cancer patients could indicate the tumor relapse.…”

Section: Introductionmentioning

confidence: 99%

“…necessary for treatment (chemotherapy, oxidative stress or neutron radiation) 18 – 21 . For instance, Ferencz et al 21 showed that serum proteins denaturation profile of recovering breast cancer patients could indicate the tumor relapse. Here, we present the preliminary, but promising, results of DSC study of serum proteins obtained from metastatic lung cancer patients that respond positively or negatively to the platinum-based chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment

Kędra-Królik

Chmielewska

Michnik

et al. 2017

Sci Rep

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Chemotherapy is a primary treatment for the metastatic lung cancer patients. To select the most effective combination of drugs, we need an efficient way of assessing tumor response. Here, we showed that differential scanning calorimetry (DSC) analysis of blood serum proteins could reveal the patient response to the treatment. If chemotherapy is effective, serum proteins DSC curve of non-small cellular lung cancer (NSCLC) case is similar to the those of the healthy individuals. If treatment fails, notable changes occur in the DSC profile of NSCLC patient’s blood serum. Our preliminary work illustrates how thermal analysis of changes in the heat capacity of blood serum proteins can provide an insight into patient response to chemotherapy – the essential information for any successive lung cancer treatment.

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“…Based on our productive collaboration with clinicians, we have new groups of PhD students enrolled in the clinical area, consistently, every year. Our research profile covers a very wide spectrum of medical/biological application, including: patients afflicted with various tumors [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]; patients in different stages of COPD [ 41 , 42 ]; the identification of the different stages of psoriasis and the effect of their drug treatment [ 43 , 44 , 45 , 46 , 47 ], including the follow-up regarding the consequences of chemotherapeutic treatment following a successful tumor operation in blood plasma [ 48 , 49 ]. The upcoming Bulgarian lab is intended to apply DSC to the investigation of multiple myeloma cases [ 50 , 51 , 52 , 53 , 54 ] in patients afflicted with colorectal cancer [ 55 ].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Sensitivity of Blood Plasma Components in Patients Afflicted with Skin, Breast and Pancreatic Forms of Cancer

Ferencz

Szatmári²,

Lőrinczy³

2022

Cancers

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According to the World Health Organization’s 2018 Global Cancer Survey, cancer is the second leading cause of death. From this survey, the third most common is breast cancer, the fifth is melanoma malignum and pancreatic adenocarcinoma ranks twentieth. Undoubtedly, the early diagnosis and monitoring of these tumors and related research is important for aspects of patient care. The aim of our present review was to explain an impressive methodology that is deemed suitable in reference to studying blood sample deviations in the case of solid tumors. Essentially, we compared the heat denaturation responses of blood plasma components through differential scanning calorimetry (DSC). In the control, between five and seven separable components can be detected, in which the primary component was albumin, while in the case of tumorous patients, the peaks of immunoglobulins were dominant. Moreover, the shape of the plasma DSC curves changed with a shift in the higher temperature ranges; thus, their pattern can be used as a suitable marker of direct immunological responses. The further development of the analysis of DSC curves raises the possibility of the early diagnosis of a potential tumor, the monitoring of diseases, or testing the efficacy of the therapy from a single drop of blood.

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Harmful effect of neoadjuvant chemotherapy monitoring by DSC on breast cancer patients’ blood plasma

Cited by 14 publications

References 28 publications

The Utility of Differential Scanning Calorimetry Curves of Blood Plasma for Diagnosis, Subtype Differentiation and Predicted Survival in Lung Cancer

The Utility of Differential Scanning Calorimetry Curves of Blood Plasma for Diagnosis, Subtype Differentiation and Predicted Survival in Lung Cancer

Blood Serum Calorimetry Indicates the Chemotherapeutic Efficacy in Lung Cancer Treatment

Thermodynamic Sensitivity of Blood Plasma Components in Patients Afflicted with Skin, Breast and Pancreatic Forms of Cancer

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