Hard Metal Pneumoconiosis

Joseph, Maurice

doi:10.1111/j.1440-1673.1968.tb03357.x

Cited by 20 publications

(6 citation statements)

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“…Since the first recognition of adverse health effects from WC-Co exposure in the 1960s (Trautmann, 1958; Bech et al , 1962; Heuer, 1962; Beritic et al , 1963; Joseph, 1968), there have been a number of reports regarding the toxicity of WC-Co in the literature both in vitro (Edel et al , 1990; Lison and Lauwerys, 1990; Lison and Lauwerys, 1992; Lison and Lauwerys, 1993; Lison et al , 1995; Anard et al , 1997; Antonini et al , 2000; Roesems et al , 2000; Fedan and Cutler, 2001; De Boeck et al , 2003b; Lombaert et al , 2008; Bastian et al , 2009; Ding et al , 2009; Kuhnel et al , 2009; Busch et al , 2010; Zhang et al , 2010; Lombaert et al , 2012) and in vivo (Kerfoot et al , 1975; Kitamura et al , 1980; Lasfargues et al , 1992; Huaux et al , 1995; Lasfargues et al , 1995; Adamis et al , 1997; Rengasamy et al , 1999; De Boeck et al , 2003a). While it is well established that composite WC-Co particles are more toxic than tungsten (W), tungsten carbide (WC) or cobalt (Co) alone, the potential contribution of WC-Co particle internalization toward observed toxicity and the mechanism by which WC-Co particles could be internalized by relevant cells has not been well-addressed.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Armstead

Arena

2014

Toxicology and Applied Pharmacology

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Tungsten carbide cobalt (WC-Co) has been recognized as a workplace inhalation hazard in the manufacturing, mining and drilling industries by the National Institute of Occupational Safety and Health. Exposure to WC-Co is known to cause “hard metal lung disease” but the relationship between exposure, toxicity and development of disease remain poorly understood. To better understand this relationship, the present study examined the role of WC-Co particle size and internalization on toxicity using lung epithelial cells. We demonstrated that nano- and micro-WC-Co particles exerted toxicity in a dose- and time-dependent manner and that nano-WC-Co particles caused significantly greater toxicity at lower concentrations and shorter exposure times compared to micro-WC-Co particles. WC-Co particles in the nano-size range (not micron-sized) were internalized by lung epithelial cells, which suggested that internalization may play a key role in the enhanced toxicity of nano-WC-Co particles over micro-WC-Co particles. Further exploration of the internalization process indicated that there may be multiple mechanisms involved in WC-Co internalization such as actin and microtubule based cytoskeletal rearrangements. These findings support our hypothesis that WC-Co particle internalization contributes to cellular toxicity and suggests that therapeutic treatments inhibiting particle internalization may serve as prophylactic approaches for those at risk of WC-Co particle exposure.

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Section: Introductionmentioning

confidence: 99%

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Armstead

Arena

2014

Toxicology and Applied Pharmacology

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“…A 42-year-old man presented with a history of dry cough and dyspnea on effort for 6 A chest radiograph taken on admission showed bilateral fine reticular opacities (Fig. 1), though that taken 6 months ago had no findings.…”

Section: Case Reportmentioning

confidence: 99%

A Case of Hard Metal Lung Disease Resembling a Hypersensitive Pneumonia in Radiological Images

Okuno¹,

Kobayashi

Kotani

et al. 2010

Intern. Med.

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“…3). The patient fulfilled the diagnostic criteria for HMLD (2,(7)(8)(9). He declined our recommendation to quit his job because he needed to make a living.…”

Section: A B C D F Ementioning

confidence: 99%

Hard Metal Lung Disease Successfully Treated with Inhaled Corticosteroids

et al. 2013

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We herein report a case of hard metal lung disease that was successfully treated with inhaled corticosteroids. A 46-year-old man was admitted to our hospital due to coughing and an abnormal shadow on a chest radiograph. He had worked as a hard metal tool sharpener for five years. Chest computed tomography scans showed centrilobular micronodules and areas of ground-glass opacity in the bilateral lung fields. Videoassociated lung biopsy specimens revealed bronchocentric interstitial pneumonia and cellular bronchiolitis. A high-energy dispersion X-ray microanalysis detected tungsten. The patient was diagnosed with hard metal lung disease. Inhaled corticosteroid therapy (800 μg of ciclesonide hydrofluoroalkane daily) resolved the patient's symptoms, elevated KL-6 level, abnormal areas of chest opacity and obstructive, restrictive and diffusion impairments.

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Hard Metal Pneumoconiosis

Cited by 20 publications

References 1 publication

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro

A Case of Hard Metal Lung Disease Resembling a Hypersensitive Pneumonia in Radiological Images

Hard Metal Lung Disease Successfully Treated with Inhaled Corticosteroids

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