Hard Metal Interstitial Lung Disease: High-Resolution Computed Tomography Appearance

Gotway, Michael B.; Golden, Jeffrey A.; Warnock, Martha L.; Koth, Laura L.; Webb, Richard; Reddy, Gautham P.; Balmes, John R.

doi:10.1097/00005382-200210000-00009

Cited by 41 publications

(24 citation statements)

References 15 publications

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“…Being more sensitive in the detection of alterations, HRCT can reveal ground-glass opacities and irregular linear opacities, as well as parenchymal distortion, traction bronchiectasis, bronchiolectasis and reticulation. (4,5) Other isolated findings include large peripheral cysts, which can represent honeycombing, as well as centrilobular nodules and emphysema. (8) If there is no contraindication, bronchial lavage and transbronchial biopsy should be performed to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…(3,4) Since it is hard and resistant to high temperatures, it is used for polishing diamonds, galvanizing armaments, drilling oil wells and cutting tools. (5,6) Although the hard metal alloy has other components, cobalt is the one responsible for inducing lung disease. (5) One group of authors stated that interstitial disease develops only when exposure to cobalt occurs in association with exposure to tungsten carbonate or diamond powder.…”

Section: Discussionmentioning

confidence: 99%

“…(5,6) Although the hard metal alloy has other components, cobalt is the one responsible for inducing lung disease. (5) One group of authors stated that interstitial disease develops only when exposure to cobalt occurs in association with exposure to tungsten carbonate or diamond powder. (1) A small number of exposed workers develop the disease, usually after ten to twelve years of exposure, although the disease can occur early.…”

Section: Discussionmentioning

confidence: 99%

“…Allergic alveolitis or hypersensitivity pneumonitis occurs in the acute phase of exposure, being considered an early (potentially reversible) inflammatory phase of fibrosis, although it can evolve to fibrosis as a result of long-term exposure. (2,4,5,7,8) tion, the case was aggravated by the use of corticosteroids, and this might have affected the results of pleurodesis.…”

Section: Discussionmentioning

confidence: 99%

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Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

et al. 2010

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A pneumoconiose por metal duro, descrita pela primeira vez em 1964, é uma doença difusa causada por inalação de partículas de cobalto. A doença pode se manifestar de três formas diferentes: asma ocupacional, doença intersticial e alveolite alérgica. Relata-se um caso de um jovem do sexo masculino, afiador de ferramentas, com quadro de tosse seca e dispnéia progressiva há um ano, apresentando-se à admissão com pneumotórax espontâneo bilateral. O diagnóstico foi confirmado através de biópsia pulmonar a céu aberto.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

et al. 2010

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“…(9) An HRCT scan can show areas of bilateral ground-glass opacity, areas of consolidation, extensive areas of reticular hyperattenuation, and traction bronchiectasis-findings that indicate fibrosis. (9,10) Other findings include honeycombing, centrilobular nodules, and emphysema. (7) Pulmonary function testing reveals restrictive lung disease.…”

Section: Discussionmentioning

confidence: 99%

Doença pulmonar por metal duro em trabalhador da indústria petrolífera

et al. 2009

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A 50-year-old male patient sought treatment at our facility. He had worked as an industrial plumber on an oil platform for 9 years and had been admitted to another hospital in 1996 for the investigation of dyspnea on exertion, mild productive cough, evening fever and arthralgia (all of which had started 5 years before that admission and had worsened 3 months prior). The patient reported having been treated for pneumonia on four occasions, with temporary improvement, had a history of systemic arterial hypertension and was a former smoker (20 pack-years) who had not smoked for 5 years. A chest X-ray showed bilateral interstitial infiltrate ( Figure 1a) IntroductionLung diseases secondary to dust inhalation and presenting an immune response mechanism involving hypersensitivity, as is the case of hard metal lung disease, tend to be designated based on histopathological aspects or pathophysiological mechanisms, despite meeting some of the criteria of pneumoconioses. Inhalation of hard metal dust is a type of occupational exposure that is rarely investigated. There is an inflammatory process that can evolve progressively, causing significant impairment of respiratory function and gas exchange, as well as considerable morbidity and mortality. We report a case of lung disease due to exposure to hard metals. The diagnosis was based on the investigation of the occupational exposure, together with the review of the clinical, radiological and histopathological findings. AbstractHard metal lung disease, which manifests as giant cell interstitial pneumonia, is caused by exposure to hard metal dust. We report the case of an oil industry worker diagnosed with hard metal lung disease. The diagnosis was based on the clinical, radiological and anatomopathological analysis, as well as on pulmonary function testing.Keywords: Alloys/adverse effects; Cobalt; Tungsten; Occupational exposure; Lung diseases, interstitial. ResumoA doença pulmonar por metal duro é uma pneumonia intersticial por células gigantes relacionada com a exposição à poeira composta por metais duros. Neste artigo é relatado o caso de um profissional da indústria petrolífera, diagnosticado com doença pulmonar por metal duro com base na documentação clínica, radiológica, funcional pulmonar e anatomopatológica.Descritores: Ligas/efeitos adversos; Cobalto; Tungstênio; Exposição ocupacional; Doenças pulmonares intersticiais. Case ReportHard metal lung disease in an oil industry worker

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Tungsten

Olalde,

Venezia

2023

Patty's Toxicology

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Tungsten is a rare metal with numerous applications, most notably in machine tools, catalysts, and superalloys. The physical and chemical properties of tungsten and its compounds of commercial importance (such as sodium tungstate, ammonium meta ‐ and para ‐tungstate, tungsten metal, tungsten carbide, and tungsten oxides), as well as tungsten industrialization, recycling, occupational exposure, and biomonitoring are discussed. Between 1970 and 1990, most tungsten toxicological investigations concerned the toxicity and health effects of cemented carbides, also known as hard metal, rather than tungsten and its compounds themselves. However, within the last decade a diversity of studies on the toxicity of the water soluble and bioavailable sodium tungstate, have been conducted to fill several toxicity knowledge gaps. Acute toxicity studies on several soluble (sodium tungstate, ammonium para ‐ and meta ‐tungstate) and sparingly water‐soluble (tungsten metal, tungsten oxides, tungsten carbide) substances reported low acute oral, dermal, and inhalation toxicity, as well as a lack of eye and dermal irritation and sensitization potential. Studies published within the last 5–7 years on sodium tungstate include oral repeated exposure, reproductive, developmental, neurotoxicological, and immunotoxicological endpoints. Several reports have incorrectly associated repeated exposure toxicity of hard metals with pure tungsten carbide. As the toxicity of hard metal does not represent the intrinsic toxicity of tungsten substances so it is discussed separately within this chapter.

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Hard Metal Interstitial Lung Disease: High-Resolution Computed Tomography Appearance

Cited by 41 publications

References 15 publications

Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

Doença pulmonar por metal duro em trabalhador da indústria petrolífera

Tungsten

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