Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

Moreira, Maria Auxiliadora Carmo; Cardoso, Amanda da Rocha Oliveira; Silva, Daniela Graner Schuwartz Tannus; Queiroz, Maria de Castro Antonelli Monteiro de Conceição; Oliveira, Albino Alegro; Noleto, Tiago Marinho Almeida

doi:10.1590/s1806-37132010000100020

Cited by 7 publications

(1 citation statement)

References 9 publications

(21 reference statements)

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“…15 En otras oportunidades, el cuadro, como en la descripción de Carmo-Moreira, comienza con un neumotórax espontáneo padecido por un afilador de cuchillos y sierras, oficio realizado durante años sin protección. 16 En la bibliografía consultada, se publican observaciones aisladas, pero se destacan algunas por la cuantía de casos. Entre 1985 y 2016 Chiarchiaro y cols.…”

Section: Neumonía Intersticial De Células Gigantesunclassified

Enfermedades del intersticio pulmonar de causa laboral. Parte II

Rey¹

2023

Rev Am Med Resp

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Section: Neumonía Intersticial De Células Gigantesunclassified

Enfermedades del intersticio pulmonar de causa laboral. Parte II

Rey¹

2023

Rev Am Med Resp

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Cobalt toxicity in humans—A review of the potential sources and systemic health effects

et al. 2017

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Cobalt (Co) and its compounds are widely distributed in nature and are part of numerous anthropogenic activities. Although cobalt has a biologically necessary role as metal constituent of vitamin B, excessive exposure has been shown to induce various adverse health effects. This review provides an extended overview of the possible Co sources and related intake routes, the detection and quantification methods for Co intake and the interpretation thereof, and the reported health effects. The Co sources were allocated to four exposure settings: occupational, environmental, dietary and medical exposure. Oral intake of Co supplements and internal exposure through metal-on-metal (MoM) hip implants deliver the highest systemic Co concentrations. The systemic health effects are characterized by a complex clinical syndrome, mainly including neurological (e.g. hearing and visual impairment), cardiovascular and endocrine deficits. Recently, a biokinetic model has been proposed to characterize the dose-response relationship and effects of chronic exposure. According to the model, health effects are unlikely to occur at blood Co concentrations under 300μg/l (100μg/l respecting a safety factor of 3) in healthy individuals, hematological and endocrine dysfunctions are the primary health endpoints, and chronic exposure to acceptable doses is not expected to pose considerable health hazards. However, toxic reactions at lower doses have been described in several cases of malfunctioning MoM hip implants, which may be explained by certain underlying pathologies that increase the individual susceptibility for Co-induced systemic toxicity. This may be associated with a decrease in Co bound to serum proteins and an increase in free ionic Co. As the latter is believed to be the primary toxic form, monitoring of the free fraction of Co might be advisable for future risk assessment. Furthermore, future research should focus on longitudinal studies in the clinical setting of MoM hip implant patients to further elucidate the dose-response discrepancies.

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Simultaneous bilateral spontaneous pneumothoraces in a patient with occupational asthma

2013

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Spontaneous pneumothoraces are relatively common; however, simultaneous bilateral spontaneous pneumothoraces (SBSP) have rarely been reported. This case report describes the presentation of SBSP in a 60-year-old man with occupational asthma. He was initially started on treatment for life-threatening asthma, but an early deterioration in symptoms prompted an urgent chest radiography that established the diagnosis of bilateral pneumothoraces. This was managed with bilateral needle thoracocentesis followed by stabilisation with intercostal chest drains. He was subsequently referred to the thoracic unit for minithoracotomy, bullectomy and talc pleurodesis. This case highlights the potential difficulties in diagnosing SBSP and advocates the necessity for prompt chest radiography when managing such presentations in the acute setting.

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Pneumoconiose por exposição a metal duro com pneumotórax bilateral espontâneo

Cited by 7 publications

References 9 publications

Enfermedades del intersticio pulmonar de causa laboral. Parte II

Enfermedades del intersticio pulmonar de causa laboral. Parte II

Cobalt toxicity in humans—A review of the potential sources and systemic health effects

Simultaneous bilateral spontaneous pneumothoraces in a patient with occupational asthma

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