Haptoglobin phenotypes as a risk factor for coronary artery disease in type 2 diabetes mellitus: An Egyptian study

Hamdy, Gehan; Hendy, Olfat; Afifi, Hala A. M.; El-Sebaey, Azza; Ali, Salwa R.; Khalaf, Fatma A.

doi:10.1016/j.ejmhg.2014.03.003

Cited by 10 publications

(12 citation statements)

References 44 publications

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“…Hp1 exerts greater antioxidant activity than Hp2, with various studies confirming the association with higher oxidative stress and diabetic complications [ 123 ]. All reported studies similarly confirmed the association with prevalence of CAD, MI or MACE in T2DM [ 121 , 122 , 124 , 125 ] (Table 4 ).…”

Section: Polymorphisms Of Heme System Genessupporting

confidence: 66%

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Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to influence oxidative stress levels and are therefore thought to impact CAD pathogenesis. Identifying higher risk groups would be rational, since it would allow better sample selection and thus better results in antioxidant trials. In this review, we summarize the evidence of oxidative stress gene polymorphisms related to the pathogenesis of CAD. Moreover, we provide a review of antioxidants tested in subjects with CAD.

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Section: Polymorphisms Of Heme System Genessupporting

confidence: 66%

“…Hp is a serum α 2 -glycoprotein, an acute phase reactant synthetized mainly in the liver. Free heme is bound by the Hp stabilizing iron within, and consequently prevents oxidative stress damage [ 121 ]. In humans, there are two alleles of Hp, Hp1 and Hp2 [ 122 ].…”

Section: Polymorphisms Of Heme System Genesmentioning

confidence: 99%

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Tibaut¹,

Petrovič

2016

CHAMC

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“…Indeed, a number of studies have associated Hp phenotypes with the development or progression of diseases, and the antioxidant activities of the phenotypes have been proposed as the underlying mechanism of the association . In type 2 diabetes, Hp2‐2 was considered to be a major susceptible gene for the development of coronary artery disease (CAD); it correlates with increased levels of inflammatory response markers . The Hp2‐2 phenotype has been implicated in increased HIV viral titres compared to the other Hp phenotypes .…”

Section: Discussionmentioning

confidence: 99%

“…Hp0 is the absence of Hp in blood, which has been attributed to mutation and/or deletion of the promoter region of the HP gene and excessive haemolysis, and results in null expression and rapid clearance of the circulatory protein, respectively . Different Hp phenotypes have been associated with different diseases due to disparities in free radical clearance by the respective phenotypes . Poor clearance of free haemoglobin (Hb) in circulation by Hp2‐2 phenotype increases iron availability for growth of iron‐dependent bacteria , and the phenotype has also been reported to increase mortality rate of HIV‐infected patients compared to Hp1‐1 and Hp2‐1 .…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV‐infected patients on highly active antiretroviral therapy

Tagoe

Kuleape

et al. 2019

Tropical Med Int Health

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objective Highly active antiretroviral therapy (HAART) has considerably reduced HIV/AIDSrelated morbidity and mortality; however, the therapy has been associated with the development of cardiovascular disease (CVD), and genetic predisposition factors may aggravate disease outcome. This study was aimed at investigating the relationship between haptoglobin phenotypes and risk factors of CVD in HIV patients.methods A total of 105 HIV sero-positive patients on HAART and 75 HIV-infected HAART-na€ ıve individuals were enrolled in the study. Socio-demographics and clinical characteristics of the participants were obtained using a well-structured questionnaire. Lipid profile, lactate dehydrogenase (LDH) and haptoglobin (Hp) phenotypes were analysed from serum whiles haemoglobin (Hb) level, CD4 + cell count and HIV viral RNA load were determined using whole blood.results Atherogenic index of plasma (AIP) was significantly higher in patients on HAART than the na€ ıve group (P < 0.05). Age, BMI, visceral fat, systolic blood pressure LDH and lipid variables strongly and positively correlated with AIP (P < 0.05), with the exception of HDL-c (P < 0.001) which showed a negative correlation. HAART was associated with hypertension (v 2 = 4.33, P = 0.037), hypercholesterolaemia (v 2 = 10.99, P < 0.001), elevated LDL-c (v 2 = 10.30, P < 0.001) and decreased HDL-c (v 2 = 3.87, P = 0.09). Hp2-2 and Hp0 collectively was strongly associated with hypertension (OR = 2.54, P = 0.011), obesity (OR = 5.97, P < 0.001) and hypercholesterolaemia (OR = 2.99, P < 0.001).

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“…Именно альфа-цепь может существовать в двух аллельных формах: альфа 1 (83 аминокислотных остатка, укороченная форма) и альфа 2 (142 аминокислотных остатка, полноразмерная форма). Таким образом, одной из причин сниженного содержания белка может быть аллельный полиморфизм, который ассоциируют с развитием различных заболеваний различных органов, в том числе сердечно-сосудистой системы [14,15]. Метод MRM позволяет отслеживать и принимать во внимание как артефакты пробоподготовки, так и структурные различия аминокислотной последовательности, обусловленные точечными мутациями или посттрансляционными модификациями.…”

Section: протеомное ядро плазмы крови человека: оценка межиндивидуальunclassified

Mass-spectrometric MRM analysis of FDA-verified proteins in the blood plasma of healthy volunteers

et al. 2020

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The proteomic composition of a biological sample serves as the most important feature of a biological object, and it allows discriminating normal and pathological conditions. Targeted mass spectrometric analysis, namely, multiple reaction monitoring (MRM) using synthetic isotopically-labeled internal standard (SIS), is the main alternative to the ELISA method for the analysis of diagnostically significant proteins. Based on the MRM results, a prototype test system has been developed; it employs the targeted mass spectrometric method for multiplex, quantitative analysis of FDA-verified proteins in whole blood plasma. Using this approach, it was possible to measure the content of 42 proteins in 31 samples in a concentration range spanning five orders of magnitude. The interindividual variability for 30 of the 42 registered proteins was less than 40%. The largest scatter was observed for haptoglobin (68%), immunoglobulin heavy constant delta IGHD (90%), angiotensin (72%), sex hormone-binding globulin SHBG (100%) and lipoprotein-(a) (136%). The obtained results on the concentration of proteins correlate with published data (Hortin et al., 2008, Clinical Chemistry, 54, 1608) with R2=0.84. The developed prototype test system based on targeted mass spectrometric analysis of proteins can be considered as an alternative to methods using monoclonal antibodies.

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Haptoglobin phenotypes as a risk factor for coronary artery disease in type 2 diabetes mellitus: An Egyptian study

Cited by 10 publications

References 44 publications

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus

Haptoglobin phenotypes with weak antioxidant capacity increase risk factors of cardiovascular disease in Ghanaian HIV‐infected patients on highly active antiretroviral therapy

Mass-spectrometric MRM analysis of FDA-verified proteins in the blood plasma of healthy volunteers

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