Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects

Rezende, Vania B.; Barbosa, Fernando; Montenegro, Marcelo F.; Sandrim, Valéria C.; Gerlach, Raquel Fernanda; Tanus‐Santos, José Eduardo

doi:10.1007/s00204-007-0231-4

Cited by 46 publications

(30 citation statements)

References 34 publications

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“…Another study of Rezende et al (2008) affirms, that subjects with the bb BsmI polymorphism or ff FokI polymorphism genotypes have lower blood lead level than subjects in the other genotype groups. Moreover, individuals with the ff FokI genotypes have lower plasma lead level than allele F carriers (Rezende et al, 2008).…”

Section: Discussionmentioning

confidence: 87%

The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead

et al. 2015

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Section: Discussionmentioning

confidence: 87%

The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead

et al. 2015

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“…However, studies on relationships between Pb and serum 25(OH)D are few; most were done more than two decades ago when BLL were much higher ($29 mg/dl) and have yielded inconsistent results (17)(18)(19)(20)(21) . (22,23) . Hence, with the improvement of the environment and prevention measures for Pb exposure, a new relationship between vitamin D and BLL that is lower than in the past should be established.…”

Section: The Concentration Of 25-hydroxyvitamin D (25(oh)d)mentioning

confidence: 99%

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Liu

Shi

et al. 2013

Public Health Nutr.

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Objective: To evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China. Design: A cross-sectional and 1-year retrospective study. Setting: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China. Subjects: Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011). Results: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33?18 (SD 16?48) ng/ml) was deficient in 21?6 % and insufficient in 27?4 %, which were higher than the prevalence of both anaemia at 8?5 % and elevated BLL (Pb $ 10 mg/dl) at 1?8 %, but lower than mildly elevated BLL prevalence (5 mg/dl # Pb , 10 mg/dl) at 56?9 %. There was a negative correlation between 25(OH)D concentration and BLL (r 5 20?216, P , 0?001) while no significant relationship was found between 25(OH)D concentration and Hb (r 5 20?012, P . 0?05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR 5 18?29; 95 % CI 10?14, 32?99; P , 0?001) and BLL (OR 5 1?01; 95 % CI 1?00, 1?02; P 5 0?045). Conclusions: The prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.

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“…Genotypes for the Fok I, ApaI and BsmI were determined by restriction fragment length polymorphism techniques as previously described [26,27].…”

Section: Genotypingmentioning

confidence: 99%

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

et al. 2012

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Hypertension is the most common medical disorder in pregnancy, and a leading cause of maternal and neonatal morbidity and mortality. Vitamin D endocrine system has important influence on immune modulation and endothelial function, which play a role in preeclampsia (PE) and gestational hypertension (GH). Vitamin D receptor (VDR) is present in a large variety of cell types, including placental cells. We examined whether there is an association between VDR polymorphisms (FokI, ApaI and BsmI) with PE or with GH. Restriction fragment length polymorphism techniques were used to genotype 529 pregnant (154 with GH, 162 with PE, and 213 healthy pregnant-HP). VDR haplotype frequencies were inferred using the PHASE 2.1 program. We found similar genotype distributions for the three VDR polymorphisms in both PE and GH groups compared with the HP group (all P [ 0.05). In parallel with these findings, the VDR haplotype frequency distribution was similar in both PE and GH groups compared with the HP group (all P [ 0.05). Our results showing no significant association between VDR polymorphisms or haplotypes with PE or GH suggest that genetic variations in VDR do not predispose to hypertensive disorders of pregnancy.

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Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects

Cited by 46 publications

References 34 publications

The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead

The relationship between selected VDR, HFE and ALAD gene polymorphisms and several basic toxicological parameters among persons occupationally exposed to lead

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

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