Haploidentical donor T cells fail to facilitate engraftment but lessen the immune response of host T cells in murine fetal transplantation

Abstract

SummaryThe effects of donor T cells, or their CD8 + subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F 1 -intoparent mouse-model that does not permit a graft-versus-host effect.

Maternal microchimerism in pediatric inflammatory bowel disease

“…The high occurrence of maternal microchimerism in healthy individuals has been suggested to have a tolerogenic effect that may contribute to long-term microchimerism. In contrast, in utero transplantation of haploidentical cells does not always lead to immune tolerance 23 and may lead to immune sensitization. Thus, the immunological consequences of the migration of maternal cells to the fetus appear to be variable.…”

The evidence of maternal microchimerism in biliary atresia using fluorescent in situ hybridization

“…If microchimeric cells are involved in the pathogenesis of BA, the reason why BA develops in some individuals and not in others is not understood. It has been reported that transplanted T lymphocyte can facilitate engraftment, often at the expense of GVHD, in bone marrow transplantation as well as in utero transplantation [22]. Moreover, the presence of donor T lymphocyte in the circulation may alter the response of the host's immune system to donor cells.…”

Maternal microchimerism in the livers of patients with Biliary atresia

“…The high occurrence of maternal microchimerism in healthy individuals has been suggested to have a tolergenic effect that may contribute to long-term microchimerism. [27]Additionally, in utero transplantation of haploidentical cells does not always lead to immune tolerance [28] and may lead to immune sensitization. Thus, the immunological consequences of the migration of maternal cells to the fetus appear to be variable.…”