The evidence of maternal microchimerism in biliary atresia using fluorescent in situ hybridization

Hayashida, Miyeko; Nishimoto, Yuko; Matsuura, Toshiharu; Takahashi, Yukiko; Kohashi, Kenichi; Souzaki, Ryota; Taguchi, Tomoaki

doi:10.1016/j.jpedsurg.2007.08.039

Cited by 43 publications

(28 citation statements)

References 22 publications

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“…Studies involving the surgical removal of biliary obstruction have revealed that, in most cases, the preformed bile ducts are affected by inflammatory processes, the causes of which are still poorly understood. BA may represent a phenotype resulting from factors which lead to biliary obstruction and include developmental anomalies, infections, vascular alterations and exposure to toxins [2,4,5] .…”

Section: Biliary Atresiamentioning

confidence: 99%

Cirrhosis in children and adolescents: An overview

Pinto

Schneider

Silveira

2015

WJH

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Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. Most cases in clinical practice are caused by similar etiologies. In infants, cirrhosis is most often caused by biliary atresia and genetic-metabolic diseases, while in older children, it tends to result from autoimmune hepatitis, Wilson's disease, alpha-1-antitrypsin deficiency and primary sclerosing cholangitis. The symptoms of cirrhosis in children and adolescents are similar to those of adults. However, in pediatric patients, the first sign of cirrhosis is often poor weight gain. The complications of pediatric cirrhosis are similar to those observed in adult patients, and include gastrointestinal bleeding caused by gastroesophageal varices, ascites and spontaneous bacterial peritonitis. In pediatric patients, special attention should be paid to the nutritional alterations caused by cirrhosis, since children and adolescents have higher nutritional requirements for growth and development. Children and adolescents with chronic cholestasis are at risk for several nutritional deficiencies. Malnutrition can have severe consequences for both pre-and post-liver transplant patients. The treatment of cirrhosis-induced portal hypertension in children and adolescents is mostly based on methods developed for adults. The present article will review the diagnostic and differential diagnostic aspects of end-stage liver disease in children, as well as the major treatment options for this condition.

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Section: Biliary Atresiamentioning

confidence: 99%

Cirrhosis in children and adolescents: An overview

Pinto

Schneider

Silveira

2015

WJH

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“…In addition, the existence of maternal microchimerism in BA was confirmed by two other researchers. 12,13 We have further quantitatively demonstrated significantly larger numbers of XX + cells in the portal area and sinusoids of male patients with BA.…”

Section: Ba As An Immune-mediated Disease With Maternal or Transmatermentioning

confidence: 64%

Maternal microchimerism in biliary atresia

Muraji¹

2014

Chimerism

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“…However, the level of microchimerism in patients with biliary atresia and other congenital liver diseases was not affected by the patient's age at biopsy (range 40 to 523 days) in one study. 16 Our study is also limited because the samples were obtained as part of clinical treatment, and thus not in a standardized manner. Analyzing tissue from a biopsy rather than a resection may bias our results toward locating microchimeric cells in the intestinal layers proximal to the bowel lumen.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with biliary atresia have a higher number of maternal chimeric cells in the liver than patients with other liver diseases. 15,16 These cells were Keywords ► Hirschsprung's disease ► microchimerism ► intestinal atresia ► chimerism Abstract Hirschsprung's disease (HD) presents with severe constipation due to absent ganglion cells in the distal rectum. We sought to determine whether maternal chimeric cells are present in aganglionic bowel.…”

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confidence: 99%

Maternal Microchimerism in Hirschsprung’s Disease

Kiefer¹,

Lang²,

Hein³

et al. 2011

Amer J Perinatol

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Hirschsprung's disease (HD) presents with severe constipation due to absent ganglion cells in the distal rectum. We sought to determine whether maternal chimeric cells are present in aganglionic bowel. We hypothesize that chimeric cells are part of the unfavorable microenvironment that leads to the destruction of enteric neurons in HD. Intestinal biopsies and resections from seven male patients with HD were compared with four male patients with chronic constipation and six with bowel atresia. Fluorescence in situ hybridization was used to identify chimeric cells based on male/female (XX/XY) differences. The location and immunophenotype of chimeric cells were also studied. Chimeric cells were present more often in the small intestine and rectum, compared with the appendix and colon. Patients with HD had a greater number of chimeric cells per 10× magnification field than patients with chronic constipation or congenital atresia. Chimeric cells were predominantly in the submucosa and outer longitudinal muscle layer in HD. Immunophenotyping identified over 40% of chimeric cells as inflammatory. Chimeric cells are present in greater numbers in aganglionic bowel than in other disorders. Clustering of chimeric cells in areas of absent ganglia lends support to the proposed role of maternal microchimerism in allo-autoimmune responses.

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The evidence of maternal microchimerism in biliary atresia using fluorescent in situ hybridization

Cited by 43 publications

References 22 publications

Cirrhosis in children and adolescents: An overview

Cirrhosis in children and adolescents: An overview

Maternal microchimerism in biliary atresia

Maternal Microchimerism in Hirschsprung’s Disease

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