Hantavirus Pulmonary Syndrome Outbreak, Brazil, December 2009–January 2010

Terças, Ana Cláudia Pereira; Santos, Marina Atanaka dos; Pignatti, Marta Gislene; Espinosa, Mariano Martínez; Via, Alba Valéria Gomes de Melo; Menegatti, Jaqueline Aparecida

doi:10.3201/eid1911.120463

Cited by 7 publications

(10 citation statements)

References 10 publications

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“…We selected EGA to represent farming production in each municipality, since farming production is thought to be associated with human exposure to wild rodents [ 12 ]. The MHDI was selected because other studies have shown that human exposure to hantavirus is also linked to low levels of human development and poverty [ 1 , 4 , 8 , 13 , 15 ]. Finally, DU was selected because some studies have shown an association between urbanization and hantavirus occurrence [ 12 , 16 ].…”

Section: Methodsmentioning

confidence: 99%

Vulnerability of Brazilian municipalities to hantavirus infections based on multi-criteria decision analysis

Oliveira

Fonseca

Vilges

et al. 2015

Emerg Themes Epidemiol

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BackgroundHantavirus infection is an emerging zoonosis transmitted by wild rodents. In Brazil, high case-fatality rates among humans infected with hantavirus are of serious concern to public health authorities. Appropriate preventive measures partly depend on reliable knowledge about the geographical distribution of this disease.MethodsIncidence of hantavirus infections in Brazil (1993–2013) was analyzed. Epidemiological, socioeconomic, and demographic indicators were also used to classify cities’ vulnerability to disease by means of multi-criteria decision analysis (MCDA).ResultsFrom 1993 to 2013, 1752 cases of hantavirus were registered in 16 Brazilian states. The highest incidence of hantavirus was observed in the states of Mato Grosso (0.57/100,000) and Santa Catarina (0.13/100,000). Based on MCDA analysis, municipalities in the southern, southeastern, and midwestern regions of Brazil can be classified as highly vulnerable. Most municipalities in northern and northeastern Brazil were classified as having low vulnerability to hantavirus cardiopulmonary syndrome.ConclusionsAlthough most human infections by hantavirus registered in Brazil occurred in the southern region of the country, a greater vulnerability to hantavirus was found in the Brazilian Midwest. This result reflects the need to strengthen surveillance where the disease has thus far gone unreported.

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Section: Methodsmentioning

confidence: 99%

Vulnerability of Brazilian municipalities to hantavirus infections based on multi-criteria decision analysis

Oliveira

Fonseca

Vilges

et al. 2015

Emerg Themes Epidemiol

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“…No Brasil, está presente em 14 estados, sendo que Mato Grosso ocupa o primeiro lugar em casos de SPH com 310 registros até 2016, esses que se concentraram na região médio norte, região predominantemente agrícola e produtora de grãos, que sofreu impactos ambientais para dar espaço à monocultura (Salbé-Travassos da Rosa, 2008;Terças, 2011). Desde o registro dos primeiros em casos em Mato Grosso, a infecção atingia em sua maioria populações agrícolas, apesar de constatação sorológica em 2009 em aldeia do cerrado, apenas em 2010 esse cenário altera-se com o primeiro registro de casos humanos em indígenas Kayabi do parque indígena do Xingú (Oliveira et al, 2010;Terças et al, 2013), a partir de então, foram registrados casos anualmente em diferentes etnias matogrossenses. Na região médio norte de Mato Grosso, responsável por 75% dos casos da doença no estado, está localizada a terra indígena Utiariti, onde residem os Haliti-Paresí, que até 2013 eram indenes para a SPH (Terças, 2011;Terças et al, 2016).…”

Section: Introductionunclassified

El conocimiento del niño Haliti–Paresí acerca de hantavirus a través de expresiones artísticas

Terças

Nascimento²,

Hattori³

et al. 2018

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“…A high seropositivity rate was observed in three studies carried out in rural areas in MT (9.43%, 13%, and 51.1%) (11) (12) (13) . These studies reported an association between the infection and agricultural activities.…”

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confidence: 97%

“…The severity of hantavirus infections can be associated with the virus type involved as well as with the different roles of the pathogenesis (15) . The Castelo dos Sonhos virus and Laguna Negra virus are associated with HCPS in both Pará and MT (13) . There are no data regarding the strains circulating in Sinop.…”

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confidence: 99%

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Vieira

Silva

Barreto

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:In Brazil, Mato Grosso (MT) has the highest number of hantavirus cardiopulmonary syndrome cases. Our study aimed to identify anti-hantavirus antibodies in the sera of patients from Sinop, MT, presenting with acute febrile illness. Methods: A retrospective analysis of data for 198 sera samples assessed using enzyme-linked immunosorbent assay (ELISA) was conducted. Results: Immunoglobulins G (IgGs) against the hantavirus nucleoprotein were found in 13.6% of the tested sera. No sample had immunoglobulin M (IgM) antibodies to hantavirus. Seropositivity occurred mainly in female residents in urban areas who worked around the household. Conclusions: Our findings suggest circulation of hantavirus in Sinop.Keywords: Zoonosis. Serosurvey study. Hantavirus.Hantaviruses (genus Hantavirus, family Bunyaviridae) are emerging zoonotic viruses of great importance for public health. In South America, the rodents of the Sigmodontinae subfamily are reservoirs of these viruses. Some hantaviruses infect humans, causing either hemorrhagic fever with renal syndrome (HFRS) and/or hantavirus cardiopulmonary syndrome (HCPS) (1) .The first cases of HCPS diagnosed in Brazil occurred in 1993. Since then, more than 1,920 cases of hantavirus have been notified in all Brazilian regions, with a case fatality rate of up to 39.5%. Mato Grosso (MT) is the leading state for HCPS cases and accounts for 16.1% of the total notified cases in Brazil. In a previous study conducted in the municipality of Sinop, Mato Grosso State, we carried out an epidemiological surveillance for arboviruses in 198 sera samples from patients presenting with acute febrile illness and clinical-epidemiological diagnoses of dengue. The results showed 46 samples positive for arboviruses. However, it was intriguing that more than 70% of the patients did not have dengue or other arbovirus infections that were tested for (2) . To address the possibility of hantavirus infection, we investigated the presence of antibodies against the hantavirus nucleoprotein in these febrile patients.Sinop is a municipality located 503km from the capital Cuiabá, in a geographical transition zone between a savannah and rainforest. The city was founded in 1974 and currently has an estimated population of approximately 130,000 inhabitants with 17.1% of them living in rural areas. The economic activities include an intensive agriculture based on the grain production, animal husbandry, logging, and human services. All of the sera analyzed in this study were part of the serum bank of the Laboratory of Immunology and Molecular Biology of Universidade Federal de Mato Grosso (UFMT), Campus of Sinop, which have been previously described in detail (2) . At the time of blood collection, the patients filled out a questionnaire that contained their epidemiological data, sex, age, occupation, address and region of birth, as well as information about any contact with rural or forested areas, and contact with rodents. These data were collected to analyze the risk factors associated with infect...

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Hantavirus Pulmonary Syndrome Outbreak, Brazil, December 2009–January 2010

Cited by 7 publications

References 10 publications

Vulnerability of Brazilian municipalities to hantavirus infections based on multi-criteria decision analysis

Vulnerability of Brazilian municipalities to hantavirus infections based on multi-criteria decision analysis

El conocimiento del niño Haliti–Paresí acerca de hantavirus a través de expresiones artísticas

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

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