Hantavirus Infections

Çelebi, Güven

doi:10.5152/kd.2011.36

Cited by 7 publications

(14 citation statements)

References 24 publications

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“…All these components increase vascular permeability and fluid extravasation occurs followed by hypotension and shock. 14,15 During the very early course of the disease, Tcell activation occur. This leads to an abrupt rise in neutrophile, monocyte, B cell and cytotoxic CD8+ T cell count.…”

Section: Pathogenesismentioning

confidence: 99%

“…Cases with high viremia and higher organ involvement have worsened course. 15 HFRS leads to renal edema and retroperitoneal leakage of fluid. Acute tubulointerstitial nephritis with mononuclear cells and CD8+cell infiltration is the most prominent finding in the renal histopathology.…”

Section: Pathogenesismentioning

confidence: 99%

“…2 Renal involvement is also less severe in PUUV infections and only 5-7% of patients require dialysis. 15 Clinical picture with DOBV infections have a similar course with PUUV but renal involvement is much more severe and 30-40% of patients may require dialysis.…”

Section: 52-53mentioning

confidence: 99%

“…of cases. 15 The outbreak lead to an important public awareness and National Hantavirus Study Group was generated. The study group found 5.2% seropositivity for Hantavirus antibodies amongst the healthy but at risk population in one of the affected provinces.…”

mentioning

confidence: 99%

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Hemorrhagic Fever with Renal Syndrome (Hantaviruses)

Berk¹,

Öztoprak²

2014

Journal of Microbiology and Infectious Diseases

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Hantaviruses are enveloped RNA viruses belonging to the genus Hantavirus, family Bunyaviridae. These agents are usual parasites of wild rodents and insectivores. Many species worldwide are infected with these viruses and each Hantavirus type is carried by its own type specific rodent species. Human transmission occurs accidentally by inhalation of aerosolized virus containing particles, contact with urine, feces or secretions of infected rodents. Hantavirus leads to two type of zoonotic infections; Hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS). Ecological and environmental changes, alterations in rodent population size, viral durability in nature, and changes in human life style that augment rodent exposure are the main causes that may affect the incidence of HFRS infection. The hallmarks of HFRS infection are fever, hypotension, hemorrhage and acute renal failure with acute interstitial nephritis. Clinical course of the disease varies between HFRS virus types. PUUV infection that is mostly seen in Europe has the mildest course and up to 90% of the cases are asymptomatic. Serological tests, molecular tests and virologic cell culture are used for HFRS diagnosis. There is no specific antiviral drug, immunotherapy or vaccine approved by Food and Drug Administration (FDA). Although ribavirin seems to decrease mortality in animal models; there are few data in the literature considering the effect of ribavirin on HFRS infections. Control and management of the symptoms with supportive care is the main modality for HFRS treatment. Reduction of the frequency and intensity of rodent exposure is very important for the prevention. J Microbiol Infect Dis 2014; Special Issue 1: S41-S49Key words: Hantavirus, hemorrhagic fever with renal syndrome, viral hemorrhagic fever, Turkey Hemorajik ateşle seyreden renal sendrom (Hantaviruslar)ÖZET Hantaviruslar Bunyaviridae ailesinin Hantavirus cinsinde yer alan zarflı RNA viruslarıdır. Bu etkenler vahşi kemirgen ve böcekçigillerin bilinen parazitlerindendir. Dünya genelinde birçok tür bu viruslarla enfektedir. Her Hantavirus tipi kendine özgül kemirgen türü ile taşınır. İnsan bulaşı virus içeren aerosolleşmiş partiküllerin inhalasyonu veya enfekte kemirgenin idrar, dışkı veya sekresyonları ile direkt temas sonucu gerçekleşir. Hantaviruslar iki tip zoonotik enfeksiyona neden olur; Hemorajik ateşle seyreden renal sendrom (HFRS) ve Hantavirus pulmoner sendrom (HPS). Ekolojik ve çevresel değişimler, kemirici populasyonundaki değişiklikler, virusun dış ortama dayanıklığı ve kemirici maruziyetini artıran insan yaşam tarzındaki değişimler HFRS insidansını artıran en önemli nedenlerdendir. HFRS enfeksiyonlarının en belirgin özel-liği ateş, hipotansiyon, kanama ve akut tübülointerstisiyal nefritle seyreden akut böbrek yetmezliğidir. Hastalığın kliniği HFRS virus tiplerine göre değişir. Avrupada sık görülen PUUV enfeksiyonu en hafif seyirli tiptir ve olguların 90% kadarı asemptomatiktir. HFRS tanısında serolojik testler, moleküler testler ve viroloji...

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Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: 52-53mentioning

confidence: 99%

mentioning

confidence: 99%

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Hemorrhagic Fever with Renal Syndrome (Hantaviruses)

Berk¹,

Öztoprak²

2014

Journal of Microbiology and Infectious Diseases

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“…Çelebi (8), Klimik Dergisi'nin bu sayısında yer alan derlemede hantavirus infeksiyonlarını kapsamlı bir biçimde gözden geçiriyor ve ülkemizde hangi hantavirusların bulunabileceğinin de altını çiziyor.…”

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Hantavirus Infection: Have We Met Before

Eraksoy¹

2012

Klimik Dergisi

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Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Çelebi

Öztoprak

Öktem

et al. 2019

Zoonoses and Public Health

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Background Some of the hantavirus species in Euro‐Asia cause haemorrhagic fever with renal syndrome (HFRS) in humans. The first documented human hantavirus infection in Turkey was diagnosed in 2009. This report describes the dynamics of the first hantavirus outbreak that emerged in humans in the Western Black Sea Region of Turkey. Methods All the suspected cases of hantavirus infection were admitted to the Infectious Diseases and Clinical Microbiology Department at the Zonguldak Bülent Ecevit University Hospital in Zonguldak, Turkey. The patients were carefully interviewed, examined and evaluated using routine laboratory tests and hantavirus diagnostic tools. Hantavirus‐reactive antibodies (IgM and IgG) in serum samples were detected via enzyme immune assay (EIA) and immunofluorescence assay (IFA) in the acute and convalescence stages of the disease. The presence of hantavirus ribonucleic acid (RNA) was analysed via reverse transcription polymerase chain reaction (RT‐PCR) in serum and urine samples. A focus reduction neutralization test (FRNT) was performed to confirm specific hantavirus serotypes. In addition, a case–control study was conducted to identify possible risk factors for hantavirus transmission in the outbreak area. A control group was composed of asymptomatic individuals who were seronegative for hantavirus IgM and IgG and living in the outbreak area. Results A total of 55 suspected cases of hantavirus infection were admitted to the inpatient clinic between February and June of 2009. Twenty‐four patients were diagnosed with acute HFRS via EIA or IFA. In 22 of the 24 infected patients, Puumala virus (PUUV) was identified as the causative hantavirus type by detecting IgM in the acute stage and an increase in the IgG level in follow‐up serum samples. PUUV was also verified as the infecting agent by FRNT in two of the 24 cases. Among the 24 laboratory‐confirmed HFRS cases, 21 (87.5%) were males and 3 (12.5%) were females, and the mean age was 45.92 years (standard deviation ± 16.90 years). Almost all these individuals were living in villages or rural areas. The 24 HFRS cases were matched with 26 healthy controls for statistical analyses and according to binary logistic regression analysis, and dealing with rodent control activities in gardens or in annexes of their homes (p = 0.021 and Odds ratio [OR] = 17.11) and being male (p = 0.019 and OR = 22.37) were detected as statistically significant risk factors for hantavirus infection. The most commonly observed clinical complaints were fatigue (95.8%), shivering (91.7%), fever (87.1%), headache (70.8%) and nausea (70.8%). Haemodialysis was required for four patients (16.7%). Except for the first case diagnosed with acute hantavirus infection, no patient died. The mean delay time to hospital admission from initiation of symptoms was 5.3 days, the mean duration of febrile days was 2.6 days, and the mean duration of hospital stay was 8.5 days. Conclusion Hantaviruses are circulating in Turkey and causing sporadic or epidemic infection in humans. Addit...

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Hantavirus Infections

Cited by 7 publications

References 24 publications

Hemorrhagic Fever with Renal Syndrome (Hantaviruses)

Hemorrhagic Fever with Renal Syndrome (Hantaviruses)

Hantavirus Infection: Have We Met Before

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

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