Handling of retroviral antigens by human antigen-presenting cells

Fenoglio, Daniela; Pira, Giuseppina Li; Saverino, Danièle; Ferraris, Anna Maria; Lancia, F.; Megiovanni, Annamaria; Oppezzi, L.; Piatti, Gabriella; Buffa, Francesca M.; Valle, Maurizio; Kunkl, Annalisa; Manca, Fabrizio

doi:10.1016/0923-2516(96)80222-6

Research in Virology

1996

DOI: 10.1016/0923-2516(96)80222-6

|View full text |Cite

Handling of retroviral antigens by human antigen-presenting cells

Daniela Fenoglio

Giuseppina Li Pira

Danièle Saverino

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2000

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13–18 While infected macrophages produce infectious virus particles in vitro and are assumed to be productive reservoirs of HTLV‐I, some studies have shown immunostimulatory effects of HTLV‐I‐infected DC. 19–21 …”

mentioning

confidence: 99%

A human B‐lineage dendritic cell line, HBM‐Noda and its potential role in human T‐cell leukemia/lymphoma virus type I infection

Nagasaki

Morikawa

Torii

et al. 2000

Pathology International

View full text Add to dashboard Cite

An Epstein-Barr virus-transformed B-cell line, HBM-Noda (Noda), that has a dendritic morphology as well as several characteristic features of dendritic cells (DC) has been established. We therefore refer to Noda as B-lineage DC. Although human T-cell leukemia/lymphoma virus type I (HTLV-I) exhibit substantial cellular tropism, the roles of DC in HTLV-I infection remain unknown. To further clarify the characteristics of Noda cells, we performed infection experiments using a concentrated HTLV-I fraction from the adult T-cell leukemia cell line, HPB-ATL-2. Noda, as well as other cell lines examined, were sensitive to HTLV-I infection as detected by proviral DNA using polymerase chain reaction, but most infected Noda cells underwent necrosis within 7 days. The most striking feature of Noda cells was the abundant expression of viral antigen (p19) on the cell surface following infection (approximately day 4), probably due to strong viral adsorption. In cocultivation experiments using Noda cells at day 1 of post-infection and peripheral blood activated T cells, we detected a few (1.3%) viral antigen expressing T cells after 5 days of coculture by flow cytometry. These results suggest that B-lineage DC such as Noda cells play a role in the establishment of HTLV-I infection at an early phase.

show abstract

mentioning

confidence: 99%

A human B‐lineage dendritic cell line, HBM‐Noda and its potential role in human T‐cell leukemia/lymphoma virus type I infection

Nagasaki

Morikawa

Torii

et al. 2000

Pathology International

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Handling of retroviral antigens by human antigen-presenting cells

Cited by 1 publication

References 20 publications

A human B‐lineage dendritic cell line, HBM‐Noda and its potential role in human T‐cell leukemia/lymphoma virus type I infection

A human B‐lineage dendritic cell line, HBM‐Noda and its potential role in human T‐cell leukemia/lymphoma virus type I infection

Contact Info

Product

Resources

About