Handheld impedance biosensor system using engineered proteinaceous receptors

Ghafar-Zadeh, Ebrahim; Chowdhury, Subrata; Aliakbar, Amir; Chodavarapu, Vamsy P.; Lambrose, Rosemond; Beital, Lenord; Trifiro, Mark

doi:10.1007/s10544-010-9451-0

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…Other approaches to portable EIS include using the commercial Analog Devices (AD) integrated circuit (IC) impedance analyzer AD5933 (Ghafar-Zadeh et al 2010). This chip combines sine wave generation, ADC, basic impedance analysis and allows multi-sine functions with discrete Fourier transform processing.…”

Section: Discussionmentioning

confidence: 99%

“…Impedance sensing is already employed in clinical diagnosis such as in electrical impedance myography (Sanchez and Rutkove 2017), blood impedance analysis (Ghafar-Zadeh et al 2010) and electrical impedance tomography (Adler and Boyle 2017). Measuring impedances over more than one frequency is considered an advantage for certain applications, with commercially-available devices for microbiology (Ramirez et al 2009) and cervical screening (Leeson 2014).…”

Section: Introductionmentioning

confidence: 99%

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POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

Sawhney

Conlan

2019

Biomed Microdevices

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Point-of-care medical devices offer the potential for rapid biomarker detection and reporting of medical conditions, thereby bypassing the requirements for offline clinical laboratory facilities in many cases. Label-free electrochemical techniques are suitable for use in handheld diagnostic devices due the inherent electronic detection modality and low requirement for processing reagents. While electrochemical impedance sensing is widely used in tissue analysis such as body composition measurement, its use in point-of-care patient testing is yet to be widely adopted. Here we have considered a number of issues currently limiting the translation of electrochemical impedance sensing into clinical biosensor devices. Specifically, we have addressed the current requirement for these sensors to be connected to an external processor by applying a minimum number of frequencies required for optimized biomarker detection, and subsequently delivering analytics within the measurement device. The POISED-5 device was evaluated using a sensor for the ovarian cancer biomarker cancer antigen 125 (CA125), demonstrating performance comparable to standard laboratory equipment, with direct interpretation of response signal amplitude substituting traditional impedance component calculation and model fitting.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

Sawhney

Conlan

2019

Biomed Microdevices

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“…Handheld biosensors are one of the most sought for analytical components to be added to the POC arsenal. Their field of applications ranges from classical glucometers to advanced devices for magnetic immunoassay tests [ 26 , 27 ]. A recently reported technique uses magnetic nanoparticles and immunoassay protocols to measure concentrations of target molecules [ 28 ].…”

Section: State-of-the Art In the Field Of Wbssmentioning

confidence: 99%

Wireless Integrated Biosensors for Point-of-Care Diagnostic Applications

Ghafar-Zadeh

2015

Sensors

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Recent advances in integrated biosensors, wireless communication and power harvesting techniques are enticing researchers into spawning a new breed of point-of-care (POC) diagnostic devices that have attracted significant interest from industry. Among these, it is the ones equipped with wireless capabilities that drew our attention in this review paper. Indeed, wireless POC devices offer a great advantage, that of the possibility of exerting continuous monitoring of biologically relevant parameters, metabolites and other bio-molecules, relevant to the management of various morbid diseases such as diabetes, brain cancer, ischemia, and Alzheimer’s. In this review paper, we examine three major categories of miniaturized integrated devices, namely; the implantable Wireless Bio-Sensors (WBSs), the wearable WBSs and the handheld WBSs. In practice, despite the aforesaid progress made in developing wireless platforms, early detection of health imbalances remains a grand challenge from both the technological and the medical points of view. This paper addresses such challenges and reports the state-of-the-art in this interdisciplinary field.

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“…A major advantage of using EIS technique is its ability to capture subtle electrochemical changes by optimizing input parameters. Impedance sensing has already paved its way into clinical entourage such as blood impedance analysis 18 , electrical impedance topography 19 and electrical impedance myography 20 .…”

Section: Introductionmentioning

confidence: 99%

Establish pre-clinical diagnostic efficacy for parathyroid hormone as a point-of-surgery-testing-device (POST)

Tanak

Muthukumar²,

Hashim

et al. 2020

Sci Rep

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Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) is a point-of-care device that uses impedance change between target and capture probe to assess the PTH concentration in undiluted patient plasma samples. The aim of this work focuses on evaluating the analytical performance of READ platform to Roche analyzer as a prospective clinical validation method. The coefficient of variation (CV) for intra-assay imprecision was < 5% and inter-assay imprecision CV was < 10% for high (942 pg/mL) and low (38.2 pg/mL) PTH concentration. Functional sensitivity defined at 15% CV was 1.9 pg/mL. Results obtained from READ platform correlated well (r = 0.99) with commercially available clinical laboratory method (Roche Diagnostics) to measure PTH concentrations with a turn-around time of less than 15 min. Furthermore, the mean bias of 7.6 pg/mL determined by Bland–Altman analysis, showed good agreement between the two methods. We envision such a sensing system would allow medical practitioners to facilitate targeted interventions, thereby, offering an immediate prognostic approach as the cornerstone to delivering successful treatment for patients suffering from primary hyperparathyroidism.

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Handheld impedance biosensor system using engineered proteinaceous receptors

Cited by 10 publications

References 27 publications

POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

Wireless Integrated Biosensors for Point-of-Care Diagnostic Applications

Establish pre-clinical diagnostic efficacy for parathyroid hormone as a point-of-surgery-testing-device (POST)

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