Handedness switching as a presenting sign for pediatric low-grade gliomas: An insight into brain plasticity from a short case series

Ghazwani, Yahya; Patay, Zoltán; Sadighi, Zsila; Sparrow, Jessica; Upadhyaya, Santhosh A.; Boop, Frederick A.; Gajjar, Amar; Qaddoumi, Ibrahim

doi:10.3233/prm-190637

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Finally, a lesion localized in the same region may induce different symptoms, depending on the individual variability of the cortical and subcortical organization of the specific sub-network, and on the possible anatomo-functional post-lesion reshaping ( Ghazwani et al, 2021 ; Duffau, 2022 ).…”

Section: Developing Network and Pathologymentioning

confidence: 99%

Structural networking of the developing brain: from maturation to neurosurgical implications

De Benedictis,

Rossi-Espagnet,

de Palma

et al. 2023

Front. Neuroanat.

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Modern neuroscience agrees that neurological processing emerges from the multimodal interaction among multiple cortical and subcortical neuronal hubs, connected at short and long distance by white matter, to form a largely integrated and dynamic network, called the brain “connectome.” The final architecture of these circuits results from a complex, continuous, and highly protracted development process of several axonal pathways that constitute the anatomical substrate of neuronal interactions. Awareness of the network organization of the central nervous system is crucial not only to understand the basis of children’s neurological development, but also it may be of special interest to improve the quality of neurosurgical treatments of many pediatric diseases. Although there are a flourishing number of neuroimaging studies of the connectome, a comprehensive vision linking this research to neurosurgical practice is still lacking in the current pediatric literature. The goal of this review is to contribute to bridging this gap. In the first part, we summarize the main current knowledge concerning brain network maturation and its involvement in different aspects of normal neurocognitive development as well as in the pathophysiology of specific diseases. The final section is devoted to identifying possible implications of this knowledge in the neurosurgical field, especially in epilepsy and tumor surgery, and to discuss promising perspectives for future investigations.

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Section: Developing Network and Pathologymentioning

confidence: 99%

Structural networking of the developing brain: from maturation to neurosurgical implications

De Benedictis,

Rossi-Espagnet,

de Palma

et al. 2023

Front. Neuroanat.

View full text Add to dashboard Cite

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Long-term follow-up of surgical intervention pattern in pediatric low-grade gliomas: report from the German SIOP-LGG 2004 cohort

Thomale

Gnekow

Kandels

et al. 2022

Journal of Neurosurgery: Pediatrics

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OBJECTIVE Neurosurgical treatment is an integral part of the treatment algorithms for pediatric low-grade glioma (LGG), yet patterns of surgical procedures are rarely challenged. The objective of this study was to evaluate surgical treatment patterns in pediatric LGG. METHODS The German Societé Internationale d’Oncologie Pédiatrique (SIOP)–LGG 2004 cohort was analyzed to identify relevant patient and tumor characteristics associated with time to death, next surgery, number of resections, and radiological outcome. RESULTS A total of 1271 patients underwent 1713 neurosurgical interventions (1 intervention in 947, 2 in 230, 3 in 70, and 4–6 in 24). The median age of the study population was 8.57 years at first surgery, and 46.1% were female. Neurofibromatosis type 1 (NF1) was found in 4.4%, and 5.4% had tumor dissemination. Three hundred fifty-four patients (27.9%) had chemotherapy and/or radiotherapy. The cumulative incidence of second surgery at 10 years was 26%, and was higher for infants, those with spinal and supratentorial midline (SML) tumors, and those with pilomyxoid astrocytomas. The hazard ratio for subsequent surgery was higher given dissemination and noncomplete initial resection, and lower for caudal brainstem and SML tumors. Among 1225 patients with fully documented surgical records and radiological outcome, 613 reached complete remission during the observation period, and 50 patients died. Patients with pilocytic astrocytoma had higher chances for a final complete remission, whereas patients with initial partial or subtotal tumor resection, dissemination, NF1, or primary tumor sites in the spinal cord and SML had lower chances. CONCLUSIONS Neurosurgery is a key element of pediatric LGG treatment. In almost 50% of the patients, however, at least some tumor burden will remain during long-term follow-up. This study found that most of these patients reached a stable disease status without further surgeries. Multidisciplinary team decisions must balance the goal of complete resection, risk factors, repeated surgeries, and possible treatment alternatives in a wide range of heterogeneous entities. Procedural details and neurological outcome should be recorded to better assess their impact on long-term outcome.

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Handedness switching as a presenting sign for pediatric low-grade gliomas: An insight into brain plasticity from a short case series

Cited by 2 publications

References 29 publications

Structural networking of the developing brain: from maturation to neurosurgical implications

Structural networking of the developing brain: from maturation to neurosurgical implications

Long-term follow-up of surgical intervention pattern in pediatric low-grade gliomas: report from the German SIOP-LGG 2004 cohort

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