Handedness and depression: A meta-analysis across 87 studies

Packheiser, Julian; Schmitz, Judith; Stein, Clara C.; Pfeifer, Lena Sophie; Berretz, Gesa; Παπαδάτου-Παστού, Μαριέττα; Peterburs, Jutta; Ocklenburg, Sebastian

doi:10.1016/j.jad.2021.07.052

Cited by 29 publications

(19 citation statements)

References 133 publications

(66 reference statements)

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“…This relation, however, has not been found for all psychiatric disorders. For example, a recent study did not find a link between handedness and depression in a meta-analysis of 87 studies totaling more than 35,000 individuals (Packheiser et al, 2021).…”

Section: Introductionmentioning

confidence: 98%

Handedness in post-traumatic stress disorder: A meta-analysis

Borawski

Παπαδάτου-Παστού

Packheiser

et al. 2023

Neuroscience & Biobehavioral Reviews

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Section: Introductionmentioning

confidence: 98%

Handedness in post-traumatic stress disorder: A meta-analysis

Borawski

Παπαδάτου-Παστού

Packheiser

et al. 2023

Neuroscience & Biobehavioral Reviews

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“…It is intriguing to speculate that LHb functional/structural asymmetry may contribute to this behavior. While a recent meta-analysis did not find handedness to be a risk factor for depression ( Packheiser et al, 2021 ), hemispheric differences in the treatment of depression using transcranial magnetic stimulation (TMS) have been observed ( Chung et al, 2015 ) suggesting that LHb streamline asymmetry may be of therapeutic importance as well.…”

Section: Discussionmentioning

confidence: 99%

Laterality and Sex Differences of Human Lateral Habenula Afferent and Efferent Fiber Tracts

et al. 2022

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IntroductionThe lateral habenula (LHb) is an epithalamic nucleus associated with negative valence and affective disorders. It receives input via the stria medullaris (SM) and sends output via the fasciculus retroflexus (FR). Here, we use tractography to reconstruct and characterize this pathway.MethodsMulti-shell human diffusion magnetic resonance imaging (dMRI) data was obtained from the human connectome project (HCP) (n = 20, 10 males) and from healthy controls (n = 10, 6 males) scanned at our institution. We generated LHb afferents and efferents using probabilistic tractography by selecting the pallidum as the seed region and the ventral tegmental area as the output target.ResultsWe were able to reconstruct the intended streamlines in all individuals from the HCP dataset and our dataset. Our technique also aided in identification of the LHb. In right-handed individuals, the streamlines were significantly more numerous in the left hemisphere (mean ratio 1.59 ± 0.09, p = 0.04). In left-handed individuals, there was no hemispheric asymmetry on average (mean ratio 1.00 ± 0.09, p = 1.0). Additionally, these streamlines were significantly more numerous in females than in males (619.9 ± 159.7 vs. 225.9 ± 66.03, p = 0.04).ConclusionWe developed a method to reconstruct the SM and FR without manual identification of the LHb. This technique enables targeting of these fiber tracts as well as the LHb. Furthermore, we have demonstrated that there are sex and hemispheric differences in streamline number. These findings may have therapeutic implications and warrant further investigation.

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“…For example, some studies regard gender as an influential factor in determining handedness and consider left-handedness more common among men than women (6). In contrast to studies which show that left-handers enjoy superiority over right-handers in terms of skills, some research indicate that neurological diseases such as epilepsy, Down syndrome, autism, mental retardation, and deafness (7) are more common among the left-handers than the ordinary population (8,9).…”

Section: Introductionmentioning

confidence: 99%

Comparing laterality and handedness between successful male and female athletes and ordinary population

Alavirad¹,

Amiri²

2022

ijhs

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Background and Purpose: Through comparing handedness and laterality between successful athletes and ordinary people, this study endeavored to investigate the probable relationship between these two factors and skills and abilities which distinguish successful athletes from other members of the society. Procedure: The sample population in the current study included Iranian men and women who were assigned into two groups of ordinary population (group 1) and successful male and female athletes (group 2). Carter’s Laterality Inventory and The Edinburgh Handedness Inventory were employed to measure laterality and handedness, respectively. It needs to be noted that validity and reliability of Persian translation of both inventories have been proved. Following the completion of the inventories, individuals’ laterality and handedness were determined, and the data were prepared for statistical analysis. Findings: The participants included 212 individuals, out of which 135 (63.7%) were male and 77 (36.3%) were female. The individuals were compared in two groups. The first group consisted of successful athletes. Out of the 130 individuals, 45 (34/6%) were female and 85 (65/4%) were male. The second group were ordinary people from private schools in Tehran which entailed 32 (39%) women and 50 (61%) men.

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Handedness and depression: A meta-analysis across 87 studies

Cited by 29 publications

References 133 publications

Handedness in post-traumatic stress disorder: A meta-analysis

Handedness in post-traumatic stress disorder: A meta-analysis

Laterality and Sex Differences of Human Lateral Habenula Afferent and Efferent Fiber Tracts

Comparing laterality and handedness between successful male and female athletes and ordinary population

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